Emulating Early Atherosclerosis in a Vascular Microphysiological System Using Branched Tissue‐Engineered Blood Vessels

2021 ◽  
pp. 2000428
Author(s):  
Jounghyun H. Lee ◽  
Zaozao Chen ◽  
Siyu He ◽  
JoyceK. Zhou ◽  
Alexander Tsai ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Tissue Engineered Blood Vessels ◽  
Early Atherosclerosis

Effect of all-trans retinoic acid and pentagalloyl glucose on smooth muscle cell elastogenesis

2021 ◽  
pp. 1-13
Author(s):  
Kaveh Sanaei ◽  
Sydney Plotner ◽  
Anson Oommen Jacob ◽  
Jaime Ramirez-Vick ◽  
Narendra Vyavahare ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Retinoic Acid ◽  
Smooth Muscle Cells ◽  
Blood Vessels ◽  
Muscle Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Tissue Engineered Blood Vessels ◽  
Pentagalloyl Glucose ◽  
Vitamin A Derivative

BACKGROUND: The main objective of tissue engineering is to fabricate a tissue construct that mimics native tissue both biologically and mechanically. A recurring problem for tissue-engineered blood vessels (TEBV) is deficient elastogenesis from seeded smooth muscle cells. Elastin is an integral mechanical component in blood vessels, allowing elastic deformation and retraction in response to the shear and pulsatile forces of the cardiac system. OBJECTIVE: The goal of this research is to assess the effect of the vitamin A derivative all-trans retinoic acid (RA) and polyphenol pentagalloyl glucose (PGG) on the expression of elastin in human aortic smooth muscle cells (hASMC). METHODS: A polycaprolactone (PCL) and the gelatin polymer composite was electrospun and doped with RA and PGG. The scaffolds were subsequently seeded with hASMCs and incubated for five weeks. The resulting tissue-engineered constructs were evaluated using qPCR and Fastin assay for their elastin expression and deposition. RESULTS: All treatments showed an increased elastin expression compared to the control, with PGG treatments showing a significant increase in gene expression and elastin deposition.

Production of Extracellular Matrix Components in Tissue-Engineered Blood Vessels

2006 ◽  
Vol 12 (4) ◽  
pp. 831-842 ◽  
Author(s):  
Sepideh Heydarkhan-Hagvall ◽  
Maricris Esguerra ◽  
Gisela Helenius ◽  
Rigmor Söderberg ◽  
Bengt R. Johansson ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Blood Vessels ◽  
Extracellular Matrix Components ◽  
Tissue Engineered Blood Vessels ◽  
Matrix Components

scholarly journals Functional tissue-engineered blood vessels from bone marrow progenitor cells

2007 ◽  
Vol 75 (3) ◽  
pp. 618-628 ◽  
Author(s):  
J LIU ◽  
D SWARTZ ◽  
H PENG ◽  
S GUGINO ◽  
J RUSSELL ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Blood Vessels ◽  
Progenitor Cells ◽  
Bone Marrow Progenitor Cells ◽  
Functional Tissue ◽  
Bone Marrow Progenitor ◽  
Tissue Engineered Blood Vessels

Stem cells in tissue-engineered blood vessels for cardiac repair

2014 ◽  
pp. 389-409
Author(s):  
H. Kurobe ◽  
M.W. Maxfield ◽  
Y. Naito ◽  
C. Breuer ◽  
T. Shinoka
Keyword(s):  
Stem Cells ◽  
Blood Vessels ◽  
Cardiac Repair ◽  
Tissue Engineered Blood Vessels

Quantitative evaluation of mechanical stimulation for tissue-engineered blood vessels

2021 ◽  
Author(s):  
Zhang Wen ◽  
Haohao Zhou ◽  
Jiahui Zhou ◽  
Wanwen Chen ◽  
Yueheng Wu ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Quantitative Evaluation ◽  
Mechanical Stimulation ◽  
Tissue Engineered Blood Vessels
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