Tissue-Engineered Blood Vessels and the Future of Tissue Substitutes

Author(s):  
Lucie Germain ◽  
Karina Laflamme ◽  
François A. Auger
2021 ◽  
pp. 1-13
Author(s):  
Kaveh Sanaei ◽  
Sydney Plotner ◽  
Anson Oommen Jacob ◽  
Jaime Ramirez-Vick ◽  
Narendra Vyavahare ◽  
...  

BACKGROUND: The main objective of tissue engineering is to fabricate a tissue construct that mimics native tissue both biologically and mechanically. A recurring problem for tissue-engineered blood vessels (TEBV) is deficient elastogenesis from seeded smooth muscle cells. Elastin is an integral mechanical component in blood vessels, allowing elastic deformation and retraction in response to the shear and pulsatile forces of the cardiac system. OBJECTIVE: The goal of this research is to assess the effect of the vitamin A derivative all-trans retinoic acid (RA) and polyphenol pentagalloyl glucose (PGG) on the expression of elastin in human aortic smooth muscle cells (hASMC). METHODS: A polycaprolactone (PCL) and the gelatin polymer composite was electrospun and doped with RA and PGG. The scaffolds were subsequently seeded with hASMCs and incubated for five weeks. The resulting tissue-engineered constructs were evaluated using qPCR and Fastin assay for their elastin expression and deposition. RESULTS: All treatments showed an increased elastin expression compared to the control, with PGG treatments showing a significant increase in gene expression and elastin deposition.


2006 ◽  
Vol 12 (4) ◽  
pp. 831-842 ◽  
Author(s):  
Sepideh Heydarkhan-Hagvall ◽  
Maricris Esguerra ◽  
Gisela Helenius ◽  
Rigmor Söderberg ◽  
Bengt R. Johansson ◽  
...  

2021 ◽  
pp. 2000428
Author(s):  
Jounghyun H. Lee ◽  
Zaozao Chen ◽  
Siyu He ◽  
JoyceK. Zhou ◽  
Alexander Tsai ◽  
...  

2007 ◽  
Vol 75 (3) ◽  
pp. 618-628 ◽  
Author(s):  
J LIU ◽  
D SWARTZ ◽  
H PENG ◽  
S GUGINO ◽  
J RUSSELL ◽  
...  

2020 ◽  
Vol 8 ◽  
Author(s):  
Kelly Stanford ◽  
Sharon Rutland ◽  
Craig J. Sturrock ◽  
Catrin Sian Rutland

Anatomy is the knowledge about the structure of the bodies of animals and people. This includes information about blood vessels, organs, the skeleton, and nerves. But have you ever wondered where the anatomical information in science books and websites comes from? When did our fascination with the body begin and why do people still study it now? Who teaches doctors, nurses, veterinary surgeons, and other health professionals about the body? How has anatomy inspired art, and vice versa? This paper looks at the amazing world of anatomy: what anatomy is; why it is needed; why it is important; who studies, teaches, and researches anatomy; and what the future holds for this fascinating science.


2014 ◽  
pp. 389-409
Author(s):  
H. Kurobe ◽  
M.W. Maxfield ◽  
Y. Naito ◽  
C. Breuer ◽  
T. Shinoka

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