scholarly journals Propagation‐based Phase Contrast Computed Tomography as a Suitable Tool for the Characterization of Spatial Three‐Dimensional Cell Distribution in Biomaterials

2021 ◽  
Author(s):  
D.C. Florian Wieland ◽  
Simone Krueger ◽  
Julian Moosmann ◽  
Thomas Distler ◽  
Alina Weizel ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Phase Contrast ◽  
Three Dimensional ◽  
Cell Distribution ◽  
Suitable Tool ◽  
Dimensional Cell

Three dimensional characterization of laser ablation craters using high resolution X-ray computed tomography

2018 ◽  
Vol 139 ◽  
pp. 75-82 ◽  
Author(s):  
A.H. Galmed ◽  
A. du Plessis ◽  
S.G. le Roux ◽  
E. Hartnick ◽  
H. Von Bergmann ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Laser Ablation ◽  
High Resolution ◽  
Three Dimensional ◽  
X Ray ◽  
X Ray Computed

Visualization of microvasculature and thrombi by X-ray phase-contrast computed tomography in hepatocellular carcinoma

2016 ◽  
Vol 23 (2) ◽  
pp. 600-605 ◽  
Author(s):  
Jianbo Jian ◽  
Hao Yang ◽  
Xinyan Zhao ◽  
Ruijiao Xuan ◽  
Yujie Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Phase Contrast ◽  
Soft Tissues ◽  
Three Dimensional ◽  
X Ray ◽  
Density Distributions ◽  
Fine Structures ◽  
Tumor Growth And Metastasis ◽  
Micrometer Scale

Visualization of the microvascular network and thrombi in the microvasculature is a key step to evaluating the development of tumor growth and metastasis, and influences treatment selection. X-ray phase-contrast computed tomography (PCCT) is a new imaging technique that can detect minute changes of density and reveal soft tissues discrimination at micrometer-scale resolution. In this study, six human resected hepatocellular carcinoma (HCC) tissues were investigated with PCCT. A histological stain was added to estimate the accuracy of PCCT. The results showed that the fine structures of the microvasculature (measuring 30–100 µm) and thrombi in tiny blood vessels were displayed clearly on imaging the HCC tissues by PCCT. Moreover, density distributions of the thrombi were obtained, which could be reliably used to distinguish malignant from benign thrombi in HCC. In conclusion, PCCT can clearly show the three-dimensional subtle structures of HCC that cannot be detected by conventional absorption-based computed tomography and provides a new method for the imageology of HCC.

Characterization of microstructure and density of polymer foam with X-ray phase contrast computed tomography

2010 ◽  
Vol 22 (10) ◽  
pp. 2331-2334 ◽  
Author(s):  
高党忠 Gao Dangzhong ◽  
马小军 Ma Xiaojun ◽  
贾鹏 Jia Peng ◽  
叶成钢 Ye Chenggang
Keyword(s):  
Computed Tomography ◽  
Phase Contrast ◽  
Polymer Foam ◽  
X Ray

scholarly journals Three-Dimensional Characterization of Tissue-Engineered Constructs by Contrast-Enhanced Nanofocus Computed Tomography

2014 ◽  
Vol 20 (3) ◽  
pp. 177-187 ◽  
Author(s):  
Ioannis Papantoniou ◽  
Maarten Sonnaert ◽  
Liesbet Geris ◽  
Frank P. Luyten ◽  
Jan Schrooten ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
Contrast Enhanced

Ex vivo characterization of pathologic fluids with quantitative phase-contrast computed tomography

2017 ◽  
Vol 86 ◽  
pp. 99-104 ◽  
Author(s):  
Vivien Richter ◽  
Marian S. Willner ◽  
John Henningsen ◽  
Lorenz Birnbacher ◽  
Mathias Marschner ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Phase Contrast ◽  
Ex Vivo ◽  
Quantitative Phase

scholarly journals Volumetric characterization of human patellar cartilage matrix on phase contrast x-ray computed tomography

2015 ◽  
Author(s):  
Anas Z. Abidin ◽  
Mahesh B. Nagarajan ◽  
Walter A. Checefsky ◽  
Paola Coan ◽  
Paul C. Diemoz ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Phase Contrast ◽  
Cartilage Matrix ◽  
X Ray ◽  
Patellar Cartilage ◽  
X Ray Computed

scholarly journals X-ray phase-contrast computed tomography visualizes the microstructure and degradation profile of implanted biodegradable scaffolds after spinal cord injury

2015 ◽  
Vol 22 (1) ◽  
pp. 136-142 ◽  
Author(s):  
Kenta Takashima ◽  
Masato Hoshino ◽  
Kentaro Uesugi ◽  
Naoto Yagi ◽  
Shojiro Matsuda ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Spinal Cord ◽  
Tissue Engineering ◽  
Phase Contrast ◽  
Three Dimensional ◽  
Injured Spinal Cord ◽  
X Ray ◽  
Biodegradable Scaffolds ◽  
Cord Injury ◽  
Grating Interferometer

Tissue engineering strategies for spinal cord repair are a primary focus of translational medicine after spinal cord injury (SCI). Many tissue engineering strategies employ three-dimensional scaffolds, which are made of biodegradable materials and have microstructure incorporated with viable cells and bioactive molecules to promote new tissue generation and functional recovery after SCI. It is therefore important to develop an imaging system that visualizes both the microstructure of three-dimensional scaffolds and their degradation process after SCI. Here, X-ray phase-contrast computed tomography imaging based on the Talbot grating interferometer is described and it is shown how it can visualize the polyglycolic acid scaffold, including its microfibres, after implantation into the injured spinal cord. Furthermore, X-ray phase-contrast computed tomography images revealed that degradation occurred from the end to the centre of the braided scaffold in the 28 days after implantation into the injured spinal cord. The present report provides the first demonstration of an imaging technique that visualizes both the microstructure and degradation of biodegradable scaffolds in SCI research. X-ray phase-contrast imaging based on the Talbot grating interferometer is a versatile technique that can be used for a broad range of preclinical applications in tissue engineering strategies.

High-Resolution Radiography for Detecting and Measuring Micron-Scale Features

2004 ◽  
Author(s):  
Daniel H. Morse ◽  
Arlyn J. Antolak ◽  
Bernice E. Mills
Keyword(s):  
Computed Tomography ◽  
Composite Materials ◽  
Phase Contrast ◽  
Three Dimensional ◽  
Conventional Radiography ◽  
Small Scale ◽  
Micro Computed Tomography ◽  
Contrast Imaging ◽  
X Ray ◽  
Projection Radiography

X-ray radiography has long been recognized as a valuable tool for detecting internal features and flaws. Recent developments in microfabrication and composite materials have extended inspection requirements to the resolution limits of conventional radiography. Our work has been directed toward pushing both detection and measurement capabilities to a smaller scale. Until recently, we have used conventional contact radiography, optimized to resolve small features. With the recent purchase of a nano-focus (sub-micron) x-ray source, we are now investigating projection radiography, phase contrast imaging and micro-computed tomography (μ-CT). Projection radiography produces a magnified image that is limited in spatial resolution mainly by the source size, not by film grain size or detector pixel size. Under certain conditions phase contrast can increase the ability to resolve small features such as cracks, especially in materials with low absorption contrast. Micro-computed tomography can provide three-dimensional measurements on a micron scale and has been shown to provide better sensitivity than simple radiographs. We have included applications of these techniques to small-scale measurements not easily made by mechanical or optical means. Examples include void detection in meso-scale nickel MEMS parts, measurement of edge profiles in thick gold lithography masks, and characterization of the distribution of phases in composite materials. Our work, so far, has been limited to film.

Computed Tomography for the Diagnosis and Characterization of Dermoid Sinuses in Two Dogs

2019 ◽  
Vol 55 (4) ◽  
Author(s):  
Susan Jones ◽  
Christopher Adin ◽  
Elizabeth Thompson ◽  
Ian Robertson ◽  
Rudy Rivas
Keyword(s):  
Computed Tomography ◽  
Phase Contrast ◽  
Single Phase ◽  
Surgical Excision ◽  
Surgical Exploration ◽  
Dermoid Sinus ◽  
Thoracolumbar Region ◽  
Contrast Ct ◽  
Invasive Diagnostics

ABSTRACT A 6 mo old male castrated bloodhound–Rhodesian ridgeback mix (case 1) presented for a mass suspected to be a dermoid sinus in the thoracolumbar region, and a 2.5 yr old male castrated Rhodesian ridgeback (case 2) presented for a mass suspected to be a dorsal cervical dermoid sinus. Both dogs underwent single-phase contrast computed tomography (CT) to characterize the extent of the dermoid sinus prior to surgical excision. Soft tissue and bony abnormalities of the vertebral spine associated with the dermoid sinuses were confirmed in both dogs prior to surgery, demonstrating communication with the dura of the spinal cord. Surgical exploration and excision of the dermoid sinus was performed in each dog, including partial laminectomy. Both cases had resolution of the sinus and an uncomplicated recovery. These cases show that single-phase contrast CT was accurate in characterizing the extent of the dermoid sinus without adjunctive tests or more invasive diagnostics. Single-phase contrast CT should be considered as a preoperative method to characterize the extent of dermoid sinuses, avoiding the risks associated with myelography or fistulography and the expense of MRI. This is also the first report of a dermoid sinus in the thoracolumbar region and the first in a bloodhound and Rhodesian ridgeback mix.

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