scholarly journals Synthesis and Characterization of Positive-Charge Functionalized Mesoporous Silica Nanoparticles for Oral Drug Delivery of an Anti-Inflammatory Drug

2008 ◽  
Vol 18 (20) ◽  
pp. 3283-3292 ◽  
Author(s):  
Chia-Hung Lee ◽  
Leu-Wei Lo ◽  
Chung-Yuan Mou ◽  
Chung-Shi Yang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Positive Charge ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Synthesis And Characterization ◽  
Functionalized Mesoporous Silica

Synthesis and Characterization of Thiol- and Carboxyl-Functionalized Mesoporous Silica Nanoparticles

2017 ◽  
Vol 1142 ◽  
pp. 220-224 ◽  
Author(s):  
Wan Xia Wang ◽  
Yu Wang ◽  
Hua Meng Gong ◽  
Hong Hao Sun ◽  
Ming Xing Liu
Keyword(s):  
Electron Microscopy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Spherical Shape ◽  
Synthesis And Characterization ◽  
Functionalized Mesoporous Silica ◽  
Transmission Electron ◽  
Ft Ir

The purpose of this article is to synthesize the thiol-and carboxyl-bifunctionalized mesoporous silica nanoparticles (CMS-SH-COOH). CMS-SH-COOH was successfully synthesized by co-condensation and post-grafting methods. Moreover, the particle size and structural properties of CMS-SH-COOH were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR). The obtained results indicated that the CMS-SH-COOH presented a uniform spherical shape with a wormhole arrangement of the mesopores and a relatively narrow paticle distribition. Therefore, the CMS-SH-COOH might be a great potential carrier for the drug delivery system in the future.

scholarly journals Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 4 ◽  
Author(s):  
Wei Zhang ◽  
Nan Zheng ◽  
Lu Chen ◽  
Luyao Xie ◽  
Mingshu Cui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Small Angle ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Pharmacokinetic Studies

The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.

Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

2014 ◽  
Vol 50 (42) ◽  
pp. 5547-5550 ◽  
Author(s):  
Amirali Popat ◽  
Siddharth Jambhrunkar ◽  
Jun Zhang ◽  
Jie Yang ◽  
Honwei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Soy Protein ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Site Specific ◽  
Modified Surface

Programme Me! Programmable mesoporous silica based nanoparticles are produced via a combination of an amino modified surface and a coating of bio-responsive soy protein.

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