Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

2014 ◽  
Vol 50 (42) ◽  
pp. 5547-5550 ◽  
Author(s):  
Amirali Popat ◽  
Siddharth Jambhrunkar ◽  
Jun Zhang ◽  
Jie Yang ◽  
Honwei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Soy Protein ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Site Specific ◽  
Modified Surface

Programme Me! Programmable mesoporous silica based nanoparticles are produced via a combination of an amino modified surface and a coating of bio-responsive soy protein.

scholarly journals Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 4 ◽  
Author(s):  
Wei Zhang ◽  
Nan Zheng ◽  
Lu Chen ◽  
Luyao Xie ◽  
Mingshu Cui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Small Angle ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Pharmacokinetic Studies

The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.

Evaluation of mesoporous silica nanoparticles for oral drug delivery – current status and perspective of MSNs drug carriers

Nanoscale ◽  
2017 ◽  
Vol 9 (40) ◽  
pp. 15252-15277 ◽  
Author(s):  
Justyna Florek ◽  
Romain Caillard ◽  
Freddy Kleitz
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Current Status ◽  
Oral Drug ◽  
Future Perspectives ◽  
Oral Drug Delivery Systems

Mesoporous silica nanocarriers are discussed as potential oral drug delivery systems, focusing on their advantages and limitations, and future perspectives.

Monitoring of “on-demand” drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles

2017 ◽  
Vol 53 (62) ◽  
pp. 8755-8758 ◽  
Author(s):  
Song Wang ◽  
Fei Liu ◽  
Xiang-Ling Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
On Demand ◽  
Controllable Release ◽  
Internal Stimulus

We constructed a versatile drug delivery system using dual internal stimulus, achieving controllable release and monitoring simultaneously.

scholarly journals An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6304-6310 ◽  
Author(s):  
Yuxia Tang ◽  
Hao Hu ◽  
Molly Gu Zhang ◽  
Jibin Song ◽  
Liming Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

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