Conceptually Novel Black Phosphorus/Cellulose Hydrogels as Promising Photothermal Agents for Effective Cancer Therapy

The constructed Cas13a/crRNA complex is delivered into cytoplasm by PBP via endocytosis, followed by endosomal escape based on biodegradation of the PBP, and efficiently knocked down Mcl-1 at transcriptional level for breast cancer therapy.

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EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report

BMC Neurology ◽

10.1186/s12883-021-02236-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zheng Wang ◽

Jiangyong Miao ◽

Lina Wang ◽

Ying Liu ◽

Hui Ji ◽

...

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Cancer Therapy ◽

Acute Ischemic Stroke ◽

Oral Anticoagulants ◽

Initial Manifestation ◽

Arterial Thromboembolism ◽

Systemic Embolization ◽

Effective Cancer Therapy

Abstract Background Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established. Case presentation We described a case of Trousseau’s syndrome resulting in acute ischemic stroke concomitant with multiple embolizations in the spleen and kidney during oral administration of dabigatran for pulmonary embolism preceding the diagnosis of a malignant tumor. A cancer-related hypercoagulable state was suspected because the patient was admitted to the neurology department due to acute ischemic stroke with three territory infarcts on diffusion-weighted imaging (DWI) in the absence of identifiable conventional risk factors and brain vessel narrowing. The patient was subsequently diagnosed with epidermal growth factor receptor (EGFR) mutation–positive non-small-cell lung cancer (NSCLC) (stage IV) with pleural metastasis. Administration of low-molecular-weight heparin followed by long-term dabigatran under effective cancer therapy comprising gefitinib and subsequent chemotherapy did not cause stroke relapse during the 1-year follow-up. Conclusions This case suggests that cancer-related hypercoagulability should be considered an important etiology for stroke patients who develop unexplained disseminated acute cerebral infarction without conventional stroke risk factors, especially concomitant with multiple organ embolization. Novel oral anticoagulants may be an alternative therapy for the long-term management of cancer-related arterial thromboembolism under effective cancer therapy.

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Composite Scaffolds of Black Phosphorus Nanosheets and Gelatin with Controlled Pore Structures for Photothermal Cancer Therapy and Adipose Tissue Engineering

Biomaterials ◽

10.1016/j.biomaterials.2021.120923 ◽

2021 ◽

pp. 120923

Author(s):

Linawati Sutrisno ◽

Huajian Chen ◽

Yazhou Chen ◽

Toru Yoshitomi ◽

Naoki Kawazoe ◽

...

Keyword(s):

Tissue Engineering ◽

Adipose Tissue ◽

Cancer Therapy ◽

Black Phosphorus ◽

Composite Scaffolds ◽

Adipose Tissue Engineering ◽

Pore Structures

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714421115 ◽

2018 ◽

Vol 115 (3) ◽

pp. 501-506 ◽

Cited By ~ 356

Author(s):

Meng Qiu ◽

Dou Wang ◽

Weiyuan Liang ◽

Liping Liu ◽

Yin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Black Phosphorus ◽

Deep Penetration ◽

Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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