A Non‐Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque

2020 ◽  
Vol 32 (38) ◽  
pp. 2000037
Author(s):  
Xiaoxiao Ge ◽  
Hongtu Cui ◽  
Jian Kong ◽  
Shi‐Yu Lu ◽  
Rui Zhan ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Photoacoustic Imaging ◽  
Vulnerable Atherosclerotic Plaque ◽  
Non Invasive

scholarly journals In vivo evaluation of vulnerable atherosclerotic plaque rabbit carotid model by optical coherence tomography

Heart ◽  
2011 ◽  
Vol 97 (Suppl 3) ◽  
pp. A17-A17
Author(s):  
S. Yanli ◽  
H. Sining ◽  
T. Jinwei ◽  
J. Haibo ◽  
M. Lingbo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Atherosclerotic Plaque ◽  
Optical Coherence ◽  
Vulnerable Atherosclerotic Plaque ◽  
In Vivo Evaluation

Non-invasive imaging of the vulnerable atherosclerotic plaque

2021 ◽  
pp. 467-480
Author(s):  
Rong Bing ◽  
David E. Newby ◽  
Jagat Narula ◽  
Marc R. Dweck
Keyword(s):  
Atherosclerotic Plaque ◽  
Vulnerable Plaque ◽  
Plaque Rupture ◽  
Imaging Techniques ◽  
Risk Scores ◽  
Plaque Imaging ◽  
Vulnerable Atherosclerotic Plaque ◽  
Acute Thrombosis ◽  
Non Invasive ◽  
Clinical Events

Cardiovascular disease remains the leading cause of death globally despite advances in medical therapy and risk stratification; ischaemic heart disease was responsible for an estimated 9.5 million deaths in 2016. To address this ongoing global burden of morbidity and mortality, there is a need for more sophisticated methods of diagnosis and prognostication, above and beyond clinical risk scores alone. The majority of myocardial infarction occurs due to ruptured atherosclerotic plaque, leading to acute thrombosis and coronary occlusion. For decades, the concept of the vulnerable plaque—plaques prone to rupture or thrombotic complications—has been central to our understanding of the pathophysiology of acute coronary syndromes. More recently, there has been a shift towards identifying the vulnerable patient through assessment of total atherosclerotic disease burden, in recognition of the fact that most plaque rupture events do not lead to clinical events. Moreover, demonstrating a strong causal link between vulnerable plaques and clinical events has previously proven difficult due to limitations in available invasive and non-invasive imaging modalities. However, we now have an array of imaging techniques that hold great potential for the advancement of vulnerable plaque imaging. These modalities are the subject of state-of-the-art clinical research, aiming to develop the role of atherosclerotic plaque imaging in modern clinical practice and ultimately to improve patient outcomes.

scholarly journals Photoacoustic Imaging of Tattoo Inks: Phantom and Clinical Evaluation

2020 ◽  
Vol 10 (3) ◽  
pp. 1024 ◽  
Author(s):  
Eftekhar Rajab Bolookat ◽  
Laurie J. Rich ◽  
Gyorgy Paragh ◽  
Oscar R. Colegio ◽  
Anurag K. Singh ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Imaging Modality ◽  
Preoperative Evaluation ◽  
Healthy Human ◽  
Non Invasive ◽  
Diagnostic Applications ◽  
Yellow Pigments ◽  
Tattoo Inks

Photoacoustic imaging (PAI) is a novel hybrid imaging modality that provides excellent optical contrast with the spatial resolution of ultrasound in vivo. The method is widely being investigated in the clinical setting for diagnostic applications in dermatology. In this report, we illustrate the utility of PAI as a non-invasive tool for imaging tattoos. Ten different samples of commercially available tattoo inks were examined for their optoacoustic properties in vitro. In vivo PAI of an intradermal tattoo on the wrist was performed in a healthy human volunteer. Black/gray, green, violet, and blue colored pigments provided higher levels of PA signal compared to white, orange, red, and yellow pigments in vitro. PAI provided excellent contrast and enabled accurate delineation of the extent of the tattoo in the dermis. Our results reveal the photoacoustic properties of tattoo inks and demonstrate the potential clinical utility of PAI for intradermal imaging of tattoos. PAI may be useful as a clinical adjunct for objective preoperative evaluation of tattoos and potentially to guide/monitor laser-based tattoo removal procedures.

Monitoring of Blood Flow by Drug Stimulation on Mouse Brain Using Non-Invasive Photoacoustic Imaging Technology

2007 ◽  
Vol 364-366 ◽  
pp. 1123-1127
Author(s):  
Shi Hua Yang ◽  
Ye Qi Lao
Keyword(s):  
Blood Flow ◽  
Mouse Brain ◽  
Light Absorption ◽  
Brain Function ◽  
Photoacoustic Imaging ◽  
Non Invasive ◽  
Mouse Cerebral Cortex ◽  
Flow Changes ◽  
The Brain

The highlight of photoacosutic imaging (PAI) is a method that combines ultrasonic resolution with high contrast due to light absorption. Photoacoustic signals carry the information of the light absorption distribution of biological tissue, which is often related to its character of structure, physiological and pathological changes because of different physiology conditions in response to different light absorption coefficients. A non-invasive PAI system was developed and successfully acquired in vivo images of mouse brain. Based on the intrinsic PA signals from the brain, the vascular network and the detailed structures of the mouse cerebral cortex were clearly visualized. The ability of PAI monitoring of cerebral hemodynamics was also demonstrated by mapping of the mouse superficial cortex with and without drug stimulation. The extracted PA signals intensity profiles obviously testified that the cerebral blood flow (CBF) in the mouse brain was changed under the stimulation of acetazolamide (ACZ). The experimental results suggest that PAI can provide non-invasive images of blood flow changes, and has the potential for brain function detection.

scholarly journals In vivo Detection of Vulnerable Atherosclerotic Plaque by MRI in a Rabbit Model

2010 ◽  
Vol 3 (3) ◽  
pp. 323-332 ◽  
Author(s):  
Alkystis Phinikaridou ◽  
Frederick L. Ruberg ◽  
Kevin J. Hallock ◽  
Ye Qiao ◽  
Ning Hua ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Rabbit Model ◽  
Vulnerable Atherosclerotic Plaque ◽  
In Vivo Detection

scholarly journals Photoacoustic imaging for the prediction and assessment of response to radiotherapy in vivo

2018 ◽  
Author(s):  
Márcia Martinho Costa ◽  
Anant Shah ◽  
Ian Rivens ◽  
Carol Box ◽  
Tuathan O’Shea ◽  
...  
Keyword(s):  
Treatment Response ◽  
Group Treatment ◽  
Photoacoustic Imaging ◽  
Subsequent Treatment ◽  
Blood Oxygen Saturation ◽  
Non Invasive ◽  
Pre Treatment ◽  
Haemoglobin Content ◽  
Better Than

AbstractRadiotherapy is commonly used for cancer therapy, although its efficacy is reduced in hypoxic regions of tumours. Photoacoustic imaging (PAI) is an emergent, non-invasive imaging technique that allows the measurement of blood oxygen saturation (sO2) which inversely correlates with hypoxia in tissue. The potential use of PAI as a prognostic tool for radiotherapy outcome was investigated in a head and neck cancer model in vivo. PAI was performed before delivering a single fraction (10, 20 or 30 Gy) treatment. The results show that tumours with pre-treatment higher blood sO2 responded better than those with lower levels in the 10 and 20 Gy groups. For the 30 Gy group, treatment response was independent of blood sO2. The haemoglobin content of the tumours was not correlated with their response to any of the radiation doses studied. Changes in sO2, monitored at 24 h and 96 h following 10 and 20 Gy doses, showed that tumours that were subsequently unresponsive to treatment had an increase in blood sO2 at both time points compared to those which subsequently regressed after radiotherapy. The results suggest that sO2 values measured by photoacoustic imaging can be used before, and shortly after, irradiation to predict subsequent treatment response.

Non-invasive and low-artifact in vivo brain imaging by using a scanning acoustic-photoacoustic dual mode microscopy

2022 ◽  
Author(s):  
Wentian Chen ◽  
Chao Tao ◽  
Zizhong Hu ◽  
Songtao Yuan ◽  
Qinghuai Liu ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Photoacoustic Imaging ◽  
Acoustic Microscopy ◽  
Acoustic Properties ◽  
Potential Candidate ◽  
Photoacoustic Microscopy ◽  
Phantom Experiment ◽  
Non Invasive ◽  
Imaging Performance

Abstract Photoacoustic imaging is a potential candidate for in-vivo brain imaging, whereas, its imaging performance could be degraded by inhomogeneous multi-layered media, consisted of scalp and skull. In this work, we propose a low-artifact photoacoustic microscopy (LAPAM) scheme, which combines conventional acoustic-resolution photoacoustic microscopy with scanning acoustic microscopy to suppress the reflection artifacts induced by multi-layers. Based on similar propagation characteristics of photoacoustic signals and ultrasonic echoes, the ultrasonic echoes can be employed as the filters to suppress the reflection artifacts to obtain low-artifact photoacoustic images. Phantom experiment is used to validate the effectiveness of this method. Furthermore, LAPAM is applied for in-vivo imaging mouse brain without removing the scalp and the skull. Experimental results show that the proposed method successfully achieves the low-artifact brain image, which demonstrates the practical applicability of LAPAM. This work might improve the photoacoustic imaging quality in many biomedical applications, which involve tissue with complex acoustic properties, such as brain imaging through scalp and skull.

Imaging the vulnerable atherosclerotic plaque

2015 ◽  
pp. 302-312
Author(s):  
David Vancraeynest ◽  
Jean-Louis J. Vanoverschelde
Keyword(s):  
Atherosclerotic Plaque ◽  
Arterial Thrombosis ◽  
Plaque Rupture ◽  
Imaging Techniques ◽  
Circulatory System ◽  
Mortality Rates ◽  
Vulnerable Atherosclerotic Plaque ◽  
Vascular Events ◽  
Non Invasive ◽  
Vulnerable Plaques

Although mortality rates from ischaemic heart disease have decreased in the past decades, diseases of the heart and circulatory system remain the main cause of death in Europe, accounting for over 4 million fatalities each year (nearly half of all deaths). Arterial thrombosis superimposed on the atherosclerotic plaque precipitates an acute vascular event, which is what underlies the high mortality rate. The plaque morphologies responsible for thrombosis are either plaque rupture or plaque erosion. Plaque rupture is the most common cause of acute vascular events, and the rupture-prone plaques are called ‘vulnerable plaques’. Because the detection of such plaques represents the ‘Holy Grail’ for every clinician, much effort has been invested in accurately detecting the presence of vulnerable plaques using different imaging techniques. This chapter provides an overview of the currently available non-invasive imaging modalities aimed at detecting vulnerable plaques and discusses their place in clinical practice.

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