Catalyst‐Free Electrophilic Ring Expansion of N‐Unprotected Aziridines with α‐Oxoketenes to Efficient Access 2‐Alkylidene‐1,3‐oxazolidines

2021 ◽  
Author(s):  
Xingpeng Chen ◽  
Zhengshuo Huang ◽  
Jiaxi Xu
Keyword(s):  
Ring Expansion ◽  
Catalyst Free ◽  
Efficient Access

Catalyst-free synthesis of oxazol-2(3H)-ones from sulfilimines and diazo compounds through a tandem rearrangement/aziridination/ring-expansion reaction

2021 ◽  
Author(s):  
Lina Song ◽  
Xianhai Tian ◽  
Chunyu Han ◽  
Mehran Amanpur ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Drug Development ◽  
Organic Synthesis ◽  
Significant Role ◽  
Ring Expansion ◽  
Diazo Compounds ◽  
Catalyst Free ◽  
Ring Expansion Reaction

Oxazol-2(3H)-ones play a significant role in the fields of organic synthesis and drug development.

ChemInform Abstract: Catalyst-Free Aza-Michael Addition of Azole to β,γ-Unsaturated-α-keto Ester: An Efficient Access to C-N Bond Formation.

ChemInform ◽  
2012 ◽  
Vol 43 (37) ◽  
pp. no-no
Author(s):  
Jun Wang ◽  
Peng-Fei Li ◽  
Sau Hing Chan ◽  
Albert S. C. Chan ◽  
Fuk Yee Kwong
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
Keto Ester ◽  
Catalyst Free ◽  
Efficient Access

Efficient Access to Imidazo[1,2-a]pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent

2018 ◽  
Vol 20 (3) ◽  
pp. 164-171 ◽  
Author(s):  
R. Nishanth Rao ◽  
Balamurali MM ◽  
Barnali Maiti ◽  
Ranjit Thakuria ◽  
Kaushik Chanda
Keyword(s):  
Microwave Irradiation ◽  
Green Solvent ◽  
Catalyst Free ◽  
Efficient Access

A Rapid Method to Aromatic Aminoalkyl Esters via the Catalyst-Free Difunctionalization of C–N Bonds

Synthesis ◽  
2018 ◽  
Vol 50 (13) ◽  
pp. 2587-2594 ◽  
Author(s):  
Qiming Zhu ◽  
Peng Yang ◽  
Mingwei Chen ◽  
Jinyu Hu ◽  
Luyi Yang
Keyword(s):  
Nitrogen Source ◽  
Rapid Method ◽  
Multicomponent Reaction ◽  
Alkyl Group ◽  
Potential Drug ◽  
Tertiary Amines ◽  
Simple Method ◽  
Catalyst Free ◽  
Free Process ◽  
Efficient Access

A novel multicomponent reaction involving a direct C–N esterification/arylation has been developed. This catalyst-free process was conducted with cyclic tertiary amines via a facile C–N cleavage to provide the alkyl group and nitrogen source. The operationally simple method to rapidly combine cyclic tertiary amines, haloazaarenes and carboxylic acids (or anhydrides) affords an efficient access to aromatic aminoalkyl esters, potential drug-like products, in good to excellent yields.

scholarly journals ‘Ring-expansion addition’ of epoxides using applied potential: an investigation of catalysts for atmospheric pressure carbon dioxide utilization

RSC Advances ◽  
2014 ◽  
Vol 4 (102) ◽  
pp. 58581-58590 ◽  
Author(s):  
Benjamin R. Buckley ◽  
Anish P. Patel ◽  
K. G. Upul Wijayantha
Keyword(s):  
Carbon Dioxide ◽  
Atmospheric Pressure ◽  
Electrode Materials ◽  
Ring Expansion ◽  
Careful Selection ◽  
Applied Potential ◽  
Free System ◽  
Catalyst Free ◽  
Carbon Dioxide Utilization ◽  
Selection Of

An investigation of catalysts for atmospheric pressure carbon dioxide insertion into epoxides under electrosynthetic conditions is reported. Careful selection of electrode materials, enabled a catalyst free system to be developed.

Catalyst-free synthesis of cycloalkenyl phosphonates

RSC Advances ◽  
2014 ◽  
Vol 4 (28) ◽  
pp. 14740-14743 ◽  
Author(s):  
Xunfu Xu ◽  
Hu Chen ◽  
Yulei Wang ◽  
Yuxing Gao ◽  
Guo Tang ◽  
...  
Keyword(s):  
Diels Alder ◽  
Catalyst Free ◽  
Efficient Access

The reactions described provide a facile and efficient access to cycloalkenyl phosphonates with good to excellent yields via Diels–Alder cycloadditions between alkynyl phosphonates and 1,3-dienes under catalyst-free conditions.

Catalyst-free aza-Michael addition of azole to β,γ-unsaturated-α-keto ester: an efficient access to C–N bond formation

2012 ◽  
Vol 53 (23) ◽  
pp. 2887-2889 ◽  
Author(s):  
Jun Wang ◽  
Peng-Fei Li ◽  
Sau Hing Chan ◽  
Albert S.C. Chan ◽  
Fuk Yee Kwong
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
Keto Ester ◽  
Catalyst Free ◽  
Efficient Access

Solvent and catalyst free ring expansion of indoles: a simple synthesis of highly functionalized benzazepines

2018 ◽  
Vol 16 (43) ◽  
pp. 8160-8168 ◽  
Author(s):  
Manickam Bakthadoss ◽  
Polu Vijay Kumar ◽  
Tadiparthi Thirupathi Reddy ◽  
Duddu S. Sharada
Keyword(s):  
Ring Expansion ◽  
Simple Synthesis ◽  
Indole Derivatives ◽  
Free Ring ◽  
Ring Contraction ◽  
Catalyst Free

Highly functionalized benzazepines have been synthesized from indoles via ring expansion. Ring contraction of benzazepines to indole derivatives has also been acheived in excellent yields.

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