Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

A novel poly(ionic liquid) (PIL)-based block copolymer, which can self-assemble into spherical nanoparticles, high drug loading content, and good ability to inhibit tumors. Therefore, this copolymer shows great potential for drug delivery.

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Utilization of L-serinyl derivate to preparing triple stimuli-responsive hydrogels for controlled drug delivery

Journal of Polymer Research ◽

10.1007/s10965-019-1976-1 ◽

2019 ◽

Vol 26 (12) ◽

Cited By ~ 3

Author(s):

Chun Hui Luo ◽

Xin Xin Sun ◽

Feng Wang ◽

Ning Wei ◽

Fa Liang Luo

Keyword(s):

Drug Delivery ◽

Controlled Drug Delivery ◽

Stimuli Responsive ◽

Responsive Hydrogels

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Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.15.188 ◽

2019 ◽

Vol 15 ◽

pp. 1925-1932 ◽

Cited By ~ 3

Author(s):

Yang Bai ◽

Cai-ping Liu ◽

Di Chen ◽

Long-hai Zhuo ◽

Huai-tian Bu ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Controlled Drug Delivery ◽

Transition Process ◽

Hydrodynamic Diameter ◽

Cancer Cell Proliferation ◽

Acidic Ph ◽

Stimuli Responsive ◽

Amphiphilic Molecules ◽

Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

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Supercritical carbon dioxide–assisted synthesis of stimuli-responsive magnetic poly(N-isopropylacrylamide)–ferrite biocompatible nanocomposites for targeted and controlled drug delivery

International Journal of Polymeric Materials ◽

10.1080/00914037.2016.1263949 ◽

2017 ◽

Vol 66 (14) ◽

pp. 708-716 ◽

Cited By ~ 4

Author(s):

Gunjan Bisht ◽

M. G. H. Zaidi ◽

Sagar Rayamajhi

Keyword(s):

Carbon Dioxide ◽

Drug Delivery ◽

Supercritical Carbon Dioxide ◽

Controlled Drug Delivery ◽

Stimuli Responsive ◽

Supercritical Carbon

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Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

Current Drug Delivery ◽

10.2174/1567201817666200917120201 ◽

2020 ◽

Vol 17 ◽

Author(s):

Ailing Feng ◽

Yanni Wang ◽

Jinzi Ding ◽

Rong Xu ◽

Xiaodong Li

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Metal Organic Framework ◽

Metal Organic Frameworks ◽

Controlled Drug Delivery ◽

Delivery Systems ◽

Stimuli Responsive ◽

Direct Assembly ◽

Metal Organic ◽

Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

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