Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib

2006 ◽  
Vol 81 (4) ◽  
pp. 242-255 ◽  
Author(s):  
Guang-Sen Zhang ◽  
Ding-Sheng Liu ◽  
Chong-Wen Dai ◽  
Rui-Juan Li
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Caspase 3 ◽  
Leukemia Cells ◽  
Antitumor Effects ◽  
Cycle Arrest ◽  
Cox 2

Dup-697, a specific COX-2 inhibitor, suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation

2007 ◽  
Vol 87 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Hong-Ling Peng ◽  
Guang-Sen Zhang ◽  
Ji-Heng Liu ◽  
Fan-Jie Gong ◽  
Rui-Juan Li
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Leukemia Cells ◽  
Caspase 8 ◽  
Cycle Arrest ◽  
Cox 2

Anticancer Effect of Amygdalin (Vitamin B-17) on Hepatocellular Carcinoma Cell Line (HepG2) in the Presence and Absence of Zinc

2020 ◽  
Vol 20 (4) ◽  
pp. 486-494
Author(s):  
Mohamed A. El-Desouky ◽  
Abdelgawad A. Fahmi ◽  
Ibrahim Y. Abdelkader ◽  
Karima M. Nasraldin
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cytochrome C ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Hepg2 Cell ◽  
Caspase 3 ◽  
Vitamin B ◽  
Cycle Arrest ◽  
Hepg2 Cell Lines

Background: Amygdalin (Vitamin B-17) is a naturally occurring vitamin found in the seeds of the fruits of Prunus Rosacea family including apricot, bitter almond, cherry, and peach. Objective: The purpose of this study was to examine the effect of amygdalin with and without zinc on hepatocellular carcinoma (HepG2) cell line. Methods: MTT assay was used to evaluate the cytotoxicity of amygdalin without zinc, amygdalin + 20μmol zinc, and amygdalin + 800μmol zinc on HepG2 cell lines. The cell cycle distribution assay was determined by flow cytometry. Apoptosis was confirmed by Annexin V-FITC/PI staining assay. Moreover, the pathway of apoptosis was determined by the percentage of change in the mean levels of P53, Bcl2, Bax, cytochrome c, and caspase-3. Results: Amygdalin without zinc showed strong anti-HepG2 activity. Furthermore, HepG2 cell lines treatment with amygdalin + 20μmol zinc and amygdalin + 800μmol zinc showed a highly significant apoptotic effect than the effect of amygdalin without zinc. Amygdalin treatment induced cell cycle arrest at G2/M and increased the levels of P53, Bax, cytochrome c, and caspase-3 significantly, while it decreased the level of anti-apoptotic Bcl2. Conclusion: Amygdalin is a natural anti-cancer agent, which can be used for the treatment of hepatocellular carcinoma. It promotes apoptosis via the intrinsic cell death pathway (the mitochondria-initiated pathway) and cell cycle arrest at G/M. The potency of amygdalin in HepG2 treatment increased significantly by the addition of zinc.

scholarly journals Pterostilbene induces cell cycle arrest and apoptosis in MOLT4 human leukemia cells

2012 ◽  
Vol 50 (4) ◽  
pp. 574-580 ◽  
Author(s):  
Kamila Siedlecka-Kroplewska ◽  
Agnieszka Jozwik ◽  
Lucyna Kaszubowska ◽  
Anna Kowalczyk ◽  
Wojciech Boguslawski
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Cycle Arrest ◽  
Human Leukemia Cells

scholarly journals Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference

Oncogene ◽  
2003 ◽  
Vol 22 (54) ◽  
pp. 8653-8661 ◽  
Author(s):  
Carsten Denkert ◽  
Antje Fürstenberg ◽  
Peter Ted Daniel ◽  
Ines Koch ◽  
Martin Köbel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Rna Interference ◽  
Ovarian Carcinoma ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Inflammatory Drug ◽  
Cycle Arrest ◽  
Ovarian Carcinoma Cells ◽  
G1 Cell Cycle Arrest ◽  
Cox 2
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