Distinct association of factor V-Leiden and prothrombin G20210A mutations with deep venous thrombosis in Tunisia and Lebanon

2006 ◽  
Vol 81 (8) ◽  
pp. 641-643 ◽  
Author(s):  
Lobna Bouaziz-Borgi ◽  
Wassim Y. Almawi ◽  
Nabil Mtiraoui ◽  
Brahim Nsiri ◽  
Sose H. Keleshian ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Factor V Leiden ◽  
Prothrombin G20210a ◽  
Factor V

Combined Factor V Leiden (R506Q) and prothrombin G20210A genotyping in young patients presenting with deep venous thrombosis

2006 ◽  
Vol 21 (1) ◽  
pp. 24-27 ◽  
Author(s):  
A Mansilha ◽  
F Araújo ◽  
M Severo ◽  
S M Sampaio ◽  
T Toledo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Young People ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Young Patients ◽  
Factor V Leiden ◽  
First Episode ◽  
Control Group ◽  
Factor V ◽  
Factor V Leiden Mutation

Objective: To evaluate the association between the Factor V Leiden (FV R506Q) and prothrombin gene (FII G20210A) mutations and deep venous thrombosis (DVT) in young people. Methods: Blood samples were drawn from 199 subjects: 100 healthy controls and 99 unselected patients, with an objectively documented first episode of DVT under 40 years old. DNA analysis was performed using the polymerase chain reaction. Results: The mean age in the patient cohort was 27 years (range 16–40) and 68 (68.7%) were women. Patient prevalences were 20.6% and 10.1% for FV R506Q and FII G20210A, respectively. In the control group, carrier frequencies were 2% and 5%, respectively. We found an increased overall relative risk of DVT with statistical significance for FV R506Q carriers (OR: 12.8; 95% CI: 2.9–56.7; P < 0.001), but not for FII G20210A mutation (OR: 2.1; 95% CI: 0.7–6.5; P = 0.19). Conclusions: Our results suggest a possible increase in DVT risk for the young G20210A allele carriers, which can be more expressed in the presence of a circumstantial risk factor. There is extremely strong evidence that the Factor V Leiden mutation is an important risk factor in the development of a first episode of DVT in young people.

Thrombophilic polymorphisms – factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T – in Tunisian patients with cerebral venous thrombosis

2012 ◽  
Vol 19 (9) ◽  
pp. 1326-1327 ◽  
Author(s):  
Olfa Ben Salem-Berrabah ◽  
Nejiba Fekih-Mrissa ◽  
Brahim N’Siri ◽  
Abdelmajid Ben Hamida ◽  
Amel Benammar-Elgaaied ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Factor V Leiden ◽  
Mthfr C677t ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Tunisian Patients

scholarly journals Risk of Recurrent Venous Thrombosis in Homozygous Carriers and Double Heterozygous Carriers of Factor V Leiden and Prothrombin G20210A

Circulation ◽  
2010 ◽  
Vol 121 (15) ◽  
pp. 1706-1712 ◽  
Author(s):  
Willem M. Lijfering ◽  
Saskia Middeldorp ◽  
Nic J.G.M. Veeger ◽  
Karly Hamulyák ◽  
Martin H. Prins ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Factor V Leiden ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Heterozygous Carriers ◽  
Recurrent Venous Thrombosis

A low rate of factor V Leiden mutation among Sudanese women with deep venous thrombosis during pregnancy and puerperium

2017 ◽  
Vol 37 (7) ◽  
pp. 963-964 ◽  
Author(s):  
Abass Awad-Elkareem ◽  
Salaheldein G. Elzaki ◽  
Hanan Khalid ◽  
Mual S. Abdallah ◽  
Ishag Adam
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Factor V Leiden ◽  
Factor V ◽  
Factor V Leiden Mutation ◽  
Low Rate
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