scholarly journals Incidence of subjective cognitive decline is associated with amyloid‐β pathology, whereas stability relates to neurodegeneration

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Gonzalo Sánchez‐Benavides ◽  
Oriol Grau‐Rivera ◽  
Marc Suárez‐Calvet ◽  
Marta Milà‐Alomà ◽  
Aida Niñerola‐Baizán ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Β ◽  
Subjective Cognitive Decline

Associations Between the Subjective Cognitive Decline-Questionnaire’s Scores, Gray Matter Volume, and Amyloid-β Levels

2019 ◽  
Vol 72 (4) ◽  
pp. 1287-1302
Author(s):  
Natalia Valech ◽  
Gonzalo Sánchez-Benavides ◽  
Adrià Tort-Merino ◽  
Nina Coll-Padrós ◽  
Jaume Olives ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Matter Volume

The psychological impact of disclosing amyloid status to Japanese elderly: a preliminary study on asymptomatic patients with subjective cognitive decline

2017 ◽  
Vol 30 (5) ◽  
pp. 635-639 ◽  
Author(s):  
Taisei Wake ◽  
Hajime Tabuchi ◽  
Kei Funaki ◽  
Daisuke Ito ◽  
Bun Yamagata ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
State Anxiety ◽  
Empirical Studies ◽  
Amyloid Β ◽  
Anxiety And Depression ◽  
Subjective Cognitive Decline ◽  
Amyloid Pet ◽  
Asymptomatic Patients ◽  
Short Period ◽  
Significant Difference

ABSTRACTIn Japan, 4.6 million people are living with dementia and the number is expected to rise to 7 million by 2025. Amyloid-β (Aβ) positron emission tomography (PET) is used for cognitively normal Japanese people with or without subjective cognitive decline (SCD) for the purpose of clinical trials or diagnosis. Nevertheless, no empirical studies have been conducted on the safety of disclosing amyloid status to such populations. We conducted amyloid PET imaging on 42 participants (Aβ positive (n = 10) and negative (n = 32)). State anxiety and depression were measured at pre- and post-disclosure, and test-related distress at post-disclosure. Mean state anxiety and depression scores were below the cut-off through pre- and post-disclosure in the Aβ positive and negative groups. State anxiety and depression did not change over time and were not different between groups. Mean test-related distress scores were within normal limits at post-disclosure in both groups. No significant difference was found between groups. Disclosing Aβ positive results did not cause greater mood disturbance than negative results in a short period of time. The short-term psychological safety of disclosing Aβ PET results to asymptomatic Japanese adults with SCD was indicated.

scholarly journals Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load

2021 ◽  
Vol 13 ◽  
Author(s):  
Claudia Schwarz ◽  
Catharina Lange ◽  
Gloria S. Benson ◽  
Nora Horn ◽  
Katharina Wurdack ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Frontal Cortex ◽  
Parietal Cortex ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Older Individuals ◽  
Cognitive Complaints ◽  
Cerebral Amyloid ◽  
State Worry ◽  
Subjective Cognitive Complaints

Subjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD and cerebral amyloid-β load measured by positron emission tomography (PET) with 18F-florbetaben in 40 cognitively normal older individuals. Global amyloid-β, as well as regional amyloid-β load for the frontal, temporal, parietal, and cingulate cortex, was quantified. Specific features of SCD, such as subjective cognitive complaints and worry, were assessed using the 39-item Everyday Cognition Scales and the 16-item Penn State Worry Questionnaire. Spearman's rank partial correlation analyses, adjusted for age and apolipoprotein E ε4 status, were conducted to test the associations between specific features of SCD and cerebral amyloid-β load. The severity of subjective cognitive complaints in everyday memory and organization was positively correlated with amyloid-β load in the frontal cortex. In addition, the severity of subjective cognitive complaints in everyday planning was positively correlated with amyloid-β load in the parietal cortex. Higher levels of worry were associated with higher amyloid-β load in the frontal cortex. After correction of the PET data for partial volume effects, these associations were reduced to trend level. In conclusion, the severity of subjective cognitive complaints and the level of trait worry were positively associated with cortical amyloid-β burden, particularly in the frontal and parietal cortex. Further studies are required to elucidate the direction of these associations in order to develop strategies to prevent amyloid deposition and cognitive decline.

scholarly journals Amyloid-β Imaging in Older Adults Presenting to a Memory Clinic with Subjective Cognitive Decline: A Pilot Study

2015 ◽  
Vol 48 (s1) ◽  
pp. S151-S159 ◽  
Author(s):  
Beth E. Snitz ◽  
Oscar L. Lopez ◽  
Eric McDade ◽  
James T. Becker ◽  
Ann D. Cohen ◽  
...  
Keyword(s):  
Older Adults ◽  
Pilot Study ◽  
Cognitive Decline ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Memory Clinic

Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE

2021 ◽  
pp. 1-11
Author(s):  
Wenying Du ◽  
Changchang Ding ◽  
Jiehui Jiang ◽  
Ying Han
Keyword(s):  
Sex Differences ◽  
Cognitive Decline ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Intracranial Volume ◽  
Elderly Individuals ◽  
Significant Difference ◽  
Scale Scores

Background: Mounting evidence suggests that sex differences exist in cognitive reserve (CR) for cognitively unimpaired (CU) elderly individuals. Global left frontal connectivity (gLFC connectivity) is a reliable neural substrate of CR. Objective: The purpose of this study was to explore sex differences in gLFC connectivity among CU elderly individuals. Methods: One hundred thirteen normal controls (NCs) (women = 66) and 132 individuals with subjective cognitive decline (SCD) (women = 92) were recruited from the Sino Longitudinal Study on Cognitive Decline (SILCODE) (data 1). Among them, 88 subjects underwent amyloid-β (Aβ) imaging, including 32 Aβ+ and 56 Aβ–subjects. Forty-six subjects underwent another rs-fMRI examination (data 2) to validate the repeatability of the calculation of gLFC connectivity, which was determined through seed-based functional connectivity between the LFC and voxels throughout the whole brain. Independent-sample t-tests were used to evaluate the sex differences in gLFC connectivity across different subgroups (NC versus SCD, Aβ+ versus Aβ–). Partial correlation analysis was used to calculate the correlations between gLFC connectivity and cognitive assessments. Results: Women exhibited lower gLFC connectivity in both the NC (p = 0.001) and SCD (p = 0.020) subgroups than men. Women also exhibited lower gLFC connectivity in both the Aβ–(p = 0.006) and Aβ+ (p = 0.025) groups. However, the significant difference disappeared in the Aβ+ group when considering the covariates of age, education, total intracranial volume, and APOE4-carrying status. In addition, gLFC connectivity values were negatively correlated with Geriatric Depression Scale scores in the SCD group (r = –0.176, p = 0.047). Conclusion: Women showed lower gLFC connectivity among CU elderly individuals.

scholarly journals Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Julia Stockmann ◽  
Inge M. W. Verberk ◽  
Nina Timmesfeld ◽  
Robin Denz ◽  
Brian Budde ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Roc Curve ◽  
External Validation ◽  
Area Under The Curve ◽  
Amyloid Β ◽  
Sensor Technology ◽  
Subjective Cognitive Decline

Abstract Background We evaluated Aβ misfolding in combination with Aβ42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD) in individuals with subjective cognitive decline (SCD). Methods Baseline plasma samples (n = 203) from SCD subjects in the SCIENCe project and Amsterdam Dementia Cohort (age 61 ± 9 years; 57% male, mean follow-up time 2.7 years) were analyzed using immuno-infrared-sensor technology. Within 6 years of follow-up, 22 (11%) individuals progressed to MCI or dementia due to AD. Sensor readout values > 1646 cm− 1 reflected normal Aβ folding; readouts at ≤ 1646 cm− 1 reflected low and at < 1644 cm− 1 high misfolding. We used Cox proportional hazard models to quantify Aβ misfolding as a prognostic biomarker for progression to MCI and dementia due to AD. The accuracy of the predicted development of MCI/AD was determined by time-dependent receiver operating characteristic (t-ROC) curve analyses that take individual follow-up and conversion times into account. Statistical models were adjusted for age, sex, and APOEε4 status. Additionally, plasma Aβ42/40 data measured by SIMOA were statistically analyzed and compared. Results All 22 patients who converted to MCI or AD-dementia within 6 years exhibited Aβ misfolding at baseline. Cox analyses revealed a hazard ratio (HR) of 19 (95% confidence interval [CI] 2.2–157.8) for future conversion of SCD subjects with high misfolding and of 11 (95% CI 1.0–110.1) for those with low misfolding. T-ROC curve analyses yielded an area under the curve (AUC) of 0.94 (95% CI 0.86–1.00; 6-year follow-up) for Aβ misfolding in an age, sex, and APOEε4 model. A similar model with plasma Aβ42/40 ratio yielded an AUC of 0.92 (95% CI, 0.82–1.00). The AUC increased to 0.99 (95% CI, 0.99–1.00) after inclusion of both Aβ misfolding and the Aβ42/40 ratio. Conclusions A panel of structure- and concentration-based plasma amyloid biomarkers may predict conversion to clinical MCI and dementia due to AD in cognitively unimpaired subjects. These plasma biomarkers provide a noninvasive and cost-effective alternative for screening early AD pathological changes. Follow-up studies and external validation in larger cohorts are in progress for further validation of our findings.

scholarly journals Correction to: Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Julia Stockmann ◽  
Inge M. W. Verberk ◽  
Nina Timmesfeld ◽  
Robin Denz ◽  
Brian Budde ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Plasma Biomarker

An amendment to this paper has been published and can be accessed via the original article.

O2-06-03: AMYLOID-β LOAD IS RELATED TO WORRIES IN INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

2006 ◽  
Vol 14 (7S_Part_11) ◽  
pp. P632-P632
Author(s):  
Sander C.J. Verfaillie ◽  
Tessa Timmers ◽  
Rosalinde E.R. Slot ◽  
Chris W.J. van der Weijden ◽  
Linda M.P. Wesselman ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Β ◽  
Subjective Cognitive Decline
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