scholarly journals Genome‐wide analysis of longitudinal Alzheimer’s disease biomarker endophenotypes

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Tanner Y. Jacobson ◽  
Kwangsik Nho ◽  
Shannon L. Risacher ◽  
Sujuan Gao ◽  
Andrew J. Saykin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genome Wide Analysis ◽  
Disease Biomarker ◽  
Genome Wide

Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease

2021 ◽  
Vol 19 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Md. Tanvir Kabir ◽  
Maroua Jalouli ◽  
Md. Ataur Rahman ◽  
Philippe Jeandet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Innate Immune ◽  
Misfolded Proteins ◽  
Inflammatory Signaling ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Immunological Mechanisms ◽  
The Brain

: Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the formation of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques. Growing evidence has suggested that AD pathogenesis is not only limited to the neuronal compartment but also strongly interacts with immunological processes in the brain. On the other hand, aggregated and misfolded proteins can bind with pattern recognition receptors located on astroglia and microglia and can in turn induce an innate immune response, characterized by the release of inflammatory mediators, ultimately playing a role in both the severity and the progression of the disease. It has been reported by genome-wide analysis that several genes which elevate the risk for sporadic AD encode for factors controlling the inflammatory response and glial clearance of misfolded proteins. Obesity and systemic inflammation are examples of external factors which may interfere with the immunological mechanisms of the brain and can induce disease progression. In this review, we discussed the mechanisms and essential role of inflammatory signaling pathways in AD pathogenesis. Indeed, interfering with immune processes and modulation of risk factors may lead to future therapeutic or preventive AD approaches.

scholarly journals Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

2010 ◽  
Vol 107 (32) ◽  
pp. 14164-14169 ◽  
Author(s):  
M. M. Lipinski ◽  
B. Zheng ◽  
T. Lu ◽  
Z. Yan ◽  
B. F. Py ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Normal Brain ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease

NeuroImage ◽  
2010 ◽  
Vol 51 (2) ◽  
pp. 542-554 ◽  
Author(s):  
Jason L. Stein ◽  
Xue Hua ◽  
Jonathan H. Morra ◽  
Suh Lee ◽  
Derrek P. Hibar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Novel Genes ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e101725 ◽  
Author(s):  
Hongxue Luo ◽  
Qi Wu ◽  
Xiaoyang Ye ◽  
Yi Xiong ◽  
Jinyong Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Mirna Signature ◽  
Genome Wide Analysis ◽  
Model Of Alzheimer’S Disease ◽  
Genome Wide

scholarly journals P1-053: Genome-wide analysis of DNA methylation differentiates late-onset Alzheimer's disease from dementia with Lewy bodies

2013 ◽  
Vol 9 ◽  
pp. P171-P172
Author(s):  
Crystal Humphries ◽  
Patrice L. Whitehead ◽  
Deborah Mash ◽  
Gary Beecham ◽  
Margaret Pericak-Vance ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Methylation ◽  
Dementia With Lewy Bodies ◽  
Late Onset ◽  
Lewy Bodies ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Erratum to: Genome-wide analysis of DNA methylation in an APP/PS1 mouse model of Alzheimer’s disease

2014 ◽  
Vol 114 (3) ◽  
pp. 207-207
Author(s):  
Lin Cong ◽  
Jianping Jia ◽  
Wei Qin ◽  
Yan Ren ◽  
Yongxin Sun
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Methylation ◽  
Mouse Model ◽  
Genome Wide Analysis ◽  
Model Of Alzheimer’S Disease ◽  
Genome Wide

P3-240: Genome-wide analysis of gene-gene interaction in Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T591-T591
Author(s):  
Eden R. Martin ◽  
Stephen D. Turner ◽  
Gary W. Beecham ◽  
Johnny R. Gilbert ◽  
Jonathan L. Haines ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Interaction ◽  
Genome Wide Analysis ◽  
Genome Wide
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