scholarly journals Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease

NeuroImage ◽  
2010 ◽  
Vol 51 (2) ◽  
pp. 542-554 ◽  
Author(s):  
Jason L. Stein ◽  
Xue Hua ◽  
Jonathan H. Morra ◽  
Suh Lee ◽  
Derrek P. Hibar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Novel Genes ◽  
Genome Wide Analysis ◽  
Genome Wide

Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease

2021 ◽  
Vol 19 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Md. Tanvir Kabir ◽  
Maroua Jalouli ◽  
Md. Ataur Rahman ◽  
Philippe Jeandet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Innate Immune ◽  
Misfolded Proteins ◽  
Inflammatory Signaling ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Immunological Mechanisms ◽  
The Brain

: Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the formation of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques. Growing evidence has suggested that AD pathogenesis is not only limited to the neuronal compartment but also strongly interacts with immunological processes in the brain. On the other hand, aggregated and misfolded proteins can bind with pattern recognition receptors located on astroglia and microglia and can in turn induce an innate immune response, characterized by the release of inflammatory mediators, ultimately playing a role in both the severity and the progression of the disease. It has been reported by genome-wide analysis that several genes which elevate the risk for sporadic AD encode for factors controlling the inflammatory response and glial clearance of misfolded proteins. Obesity and systemic inflammation are examples of external factors which may interfere with the immunological mechanisms of the brain and can induce disease progression. In this review, we discussed the mechanisms and essential role of inflammatory signaling pathways in AD pathogenesis. Indeed, interfering with immune processes and modulation of risk factors may lead to future therapeutic or preventive AD approaches.

scholarly journals Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

2010 ◽  
Vol 107 (32) ◽  
pp. 14164-14169 ◽  
Author(s):  
M. M. Lipinski ◽  
B. Zheng ◽  
T. Lu ◽  
Z. Yan ◽  
B. F. Py ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Normal Brain ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease

PLoS Genetics ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. e1009363
Author(s):  
Nana Liu ◽  
Jiayuan Xu ◽  
Huaigui Liu ◽  
Shijie Zhang ◽  
Miaoxin Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Meta Analysis ◽  
Hippocampal Volume ◽  
Genome Wide Association ◽  
Novel Genes ◽  
Genome Wide ◽  
Mapping Models

Genome-wide association studies (GWASs) have identified multiple susceptibility loci for Alzheimer’s disease (AD), which is characterized by early and progressive damage to the hippocampus. However, the association of hippocampal gene expression with AD and the underlying neurobiological pathways remain largely unknown. Based on the genomic and transcriptomic data of 111 hippocampal samples and the summary data of two large-scale meta-analyses of GWASs, a transcriptome-wide association study (TWAS) was performed to identify genes with significant associations between hippocampal expression and AD. We identified 54 significantly associated genes using an AD-GWAS meta-analysis of 455,258 individuals; 36 of the genes were confirmed in another AD-GWAS meta-analysis of 63,926 individuals. Fine-mapping models further prioritized 24 AD-related genes whose effects on AD were mediated by hippocampal expression, including APOE and two novel genes (PTPN9 and PCDHA4). These genes are functionally related to amyloid-beta formation, phosphorylation/dephosphorylation, neuronal apoptosis, neurogenesis and telomerase-related processes. By integrating the predicted hippocampal expression and neuroimaging data, we found that the hippocampal expression of QPCTL and ERCC2 showed significant difference between AD patients and cognitively normal elderly individuals as well as correlated with hippocampal volume. Mediation analysis further demonstrated that hippocampal volume mediated the effect of hippocampal gene expression (QPCTL and ERCC2) on AD. This study identifies two novel genes associated with AD by integrating hippocampal gene expression and genome-wide association data and reveals candidate hippocampus-mediated neurobiological pathways from gene expression to AD.

scholarly journals Genome‐wide analysis of longitudinal Alzheimer’s disease biomarker endophenotypes

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Tanner Y. Jacobson ◽  
Kwangsik Nho ◽  
Shannon L. Risacher ◽  
Sujuan Gao ◽  
Andrew J. Saykin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genome Wide Analysis ◽  
Disease Biomarker ◽  
Genome Wide

scholarly journals Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e101725 ◽  
Author(s):  
Hongxue Luo ◽  
Qi Wu ◽  
Xiaoyang Ye ◽  
Yi Xiong ◽  
Jinyong Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Mirna Signature ◽  
Genome Wide Analysis ◽  
Model Of Alzheimer’S Disease ◽  
Genome Wide

scholarly journals P1-053: Genome-wide analysis of DNA methylation differentiates late-onset Alzheimer's disease from dementia with Lewy bodies

2013 ◽  
Vol 9 ◽  
pp. P171-P172
Author(s):  
Crystal Humphries ◽  
Patrice L. Whitehead ◽  
Deborah Mash ◽  
Gary Beecham ◽  
Margaret Pericak-Vance ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Methylation ◽  
Dementia With Lewy Bodies ◽  
Late Onset ◽  
Lewy Bodies ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

2020 ◽  
Vol 16 (8) ◽  
pp. 1134-1145
Author(s):  
Richard Sherva ◽  
Alden Gross ◽  
Shubhabrata Mukherjee ◽  
Ryan Koesterer ◽  
Philippe Amouyel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Novel Genes ◽  
Genome Wide
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