scholarly journals Collaborative Approach for Asian Americans and Pacific Islanders Research and Education (CARE): A recruitment registry for Alzheimer’s disease and related dementias, aging and caregiver‐related research

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Van Ta Park ◽  
Oanh L Meyer ◽  
Janice Y Tsoh ◽  
Quyen Vuong ◽  
Joon Bang ◽  
...  
Author(s):  
Lili Pan ◽  
Yu Ma ◽  
Yunchun Li ◽  
Haoxing Wu ◽  
Rui Huang ◽  
...  

Abstract:: Recent studies have proven that the purinergic signaling pathway plays a key role in neurotransmission and neuromodulation, and is involved in various neurodegenerative diseases and psychiatric disorders. With the characterization of the subtypes of receptors in purinergic signaling, i.e. the P1 (adenosine), P2X (ion channel) and P2Y (G protein-coupled), more attentions were paid to the pathophysiology and therapeutic potential of purinergic signaling in central nervous system disorders. Alzheimer’s disease (AD) is a progressive and deadly neurodegenerative disease that is characterized by memory loss, cognitive impairment and dementia. However, as drug development aimed to prevent or control AD follows a series of failures in recent years, more researchers focused on the neuroprotection-related mechanisms such as purinergic signaling in AD patients to find a potential cure. This article reviews the recent discoveries of purinergic signaling in AD, summaries the potential agents as modulators for the receptors of purinergic signaling in AD related research and treatments. Thus, our paper provided an insight for purinergic signaling in the development of anti-AD therapies.


2019 ◽  
pp. 237-250
Author(s):  
Anna Maria Jadwiga Wegierek ◽  
◽  
Katarzyna Lesniak ◽  
Shan Patel ◽  
Yuliya Bogdanovskaya ◽  
...  

2017 ◽  
Vol 26 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Yuri Jang ◽  
Hyunwoo Yoon ◽  
Nan Sook Park ◽  
Min‐Kyoung Rhee ◽  
David A. Chiriboga

2020 ◽  
pp. 073346482096759
Author(s):  
Sahnah Lim ◽  
Stella Chong ◽  
Deborah Min ◽  
Sadia Mohaimin ◽  
Timothy Roberts ◽  
...  

With growing numbers of aging Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPIs), the availability of culturally and linguistically appropriate screening tools for Alzheimer’s disease and its related dementias (ADRD) is needed. The aim of this scoping review is to summarize the tools that have been adapted for and validated among the AANHPI population. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for systematic reviews, six databases were searched for peer-reviewed articles describing ADRD among AANHPIs. Among 1,477 articles screened for inclusion, 15 articles were included in the final analysis. Results showed a paucity of studies that psychometrically validate tools among this population. Furthermore, studies that culturally adapted and/or translated existing tools mostly targeted East Asian American populations. Our review provides a first step in mapping the extant literature on ADRD screening tools for this underresearched population and will serve as a guide for future research, policy, and intervention.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 277-278
Author(s):  
Jiaming Liang ◽  
Yuri Jang

Abstract Cumulative studies have investigated Alzheimer’s disease (AD)-related issues among Asian Americans, but few have considered ethnic diversities within the Asian group. Using an ethnic-diverse Asian American sample, the present study explored the prevalence, ethnic variations, and predictors of stigmatizing beliefs about AD: (1) AD is a normal process of aging, (2) it is embarrassing to have a family member with AD, and (3) social interactions with an AD patient should be avoided. Inspired by the sociocultural health beliefs model, a focus was given on the role of immigration and culture-related variables. Using data from the 2015 Asian American Quality of Life survey (N = 2609, age range = 18-98) that includes Chinese, Asian Indian, Korean, Vietnamese, Filipino, and other Asians, logistic regression was conducted to examine how each of the three stigmatizing beliefs would be predicted by (1) demographic variables and (2) immigration and culture-related variables. Results indicate that the prevalence of the stigmatizing beliefs about AD varied across ethnicities. More than 63% of Vietnamese associated AD with a normal process of aging, and about 10% of Chinese reported that they would feel embarrassed if their family member had AD. Logistic regression models demonstrated that advanced age, male gender, low education, and limited English proficiency increased the odds of reporting one or multiple stigmatizing beliefs about AD. The findings suggest a varying degree of AD-related misconceptions and stigmatization and call attention to the need for culturally sensitive community education on AD in Asian communities.


2020 ◽  
Vol 32 (10) ◽  
pp. 1579-1590
Author(s):  
Andrea H. Hermosura ◽  
Carolyn J. Noonan ◽  
Amber L. Fyfe-Johnson ◽  
Todd B. Seto ◽  
Joseph K. Kaholokula ◽  
...  

Objective: To compare important indicators of quality of care between Native Hawaiians and other Pacific Islanders (NHOPIs) and non-Hispanic Whites (NHWs) with Alzheimer’s disease and related dementias (ADRD). Methods: We used the Health Care Cost and Utilization Project, Hawaii State Inpatient Databases, 2010–2014. They included 10,645 inpatient encounters from 7,145 NHOPI or NHW patients age ≥ 50 years, residing in Hawaii, and with at least one ADRD diagnosis in the discharge record. Outcome variables were inpatient mortality, length of hospital stay, and hospital readmission. Results: NHOPIs with ADRD had, on average, a hospital stay of .94 days less than NHWs with ADRD but were 1.16 times more likely than NHWs to be readmitted. Discussion: These patterns have important clinical care implications for NHOPIs and NHWs with ADRD as they are important indicators of quality of care. Future studies should consider specific contributors to these differences in order to develop appropriate interventions.


2006 ◽  
Vol 20 (1) ◽  
pp. 11-25 ◽  
Author(s):  
Randi S. Jones ◽  
Tiffany W. Chow ◽  
Margaret Gatz

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