scholarly journals Stereoselective and Stereospecific Triflate‐Mediated Intramolecular Schmidt Reaction: Ready Access to Alkaloid Skeletons**

2021 ◽  
Vol 60 (18) ◽  
pp. 10179-10185
Author(s):  
Lars Gnägi ◽  
Remo Arnold ◽  
Florence Giornal ◽  
Harish Jangra ◽  
Ajoy Kapat ◽  
...  
Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 781
Author(s):  
Ernesto Enríquez-Palacios ◽  
Teresa Arbeloa ◽  
Jorge Bañuelos ◽  
Claudia I. Bautista-Hernández ◽  
José G. Becerra-González ◽  
...  

Herein we report on a straightforward access method for boron dipyrromethene dyes (BODIPYs)-coumarin hybrids linked through their respective 8- and 6- positions, with wide functionalization of the coumarin fragment, using salicylaldehyde as a versatile building block. The computationally-assisted photophysical study unveils broadband absorption upon proper functionalization of the coumarin, as well as the key role of the conformational freedom of the coumarin appended at the meso position of the BODIPY. Such free motion almost suppresses the fluorescence signal, but enables us to apply these dyads as molecular rotors to monitor the surrounding microviscosity.


Author(s):  
Guillaume Bousrez ◽  
Olivier Renier ◽  
Steven P. Kelley ◽  
Brando Adranno ◽  
Elnaz Tahavori ◽  
...  

ChemInform ◽  
2011 ◽  
Vol 43 (1) ◽  
pp. no-no
Author(s):  
Thomas O. Painter ◽  
Paul D. Thornton ◽  
Mario Orestano ◽  
Conrad Santini ◽  
Michael G. Organ ◽  
...  

Tetrahedron ◽  
2014 ◽  
Vol 70 (3) ◽  
pp. 643-649 ◽  
Author(s):  
Xiaowei Sun ◽  
Chengzhe Gao ◽  
Fan Zhang ◽  
Zhuang Song ◽  
Lingyi Kong ◽  
...  

2012 ◽  
Vol 134 (15) ◽  
pp. 6528-6531 ◽  
Author(s):  
Ruzhang Liu ◽  
Osvaldo Gutierrez ◽  
Dean J. Tantillo ◽  
Jeffrey Aubé
Keyword(s):  

2015 ◽  
Vol 77 (3) ◽  
Author(s):  
Helmi Mohammed Al-Maqtari ◽  
Joazaizulfazli Jamalis ◽  
Hasnah Mohd Sirat

Heterocyclic chalcones containing halogenated thiophenes were synthesized. The first step was to synthesize 3-acetyl-2,5-dichlorothiophene and 2-acetyl-5-chlorothiophene as heterocyclic ketones by using Friedel-Crafts acylation. The ketones were then used to synthesize thiophene chalcones through Claisen-Schmidt reaction with the respective heterocyclic aldehydes such as 5-bromothiophene-2-carbaldehyde, 3-methyl-2-thiophene carboxaldehyde and 2-thiophene carboxaldehyde with 3-acetyl-2,5-dichlorothiophene or 2-acetyl-5-chlorothiophene in presence of basic medium, sodium hydroxide to form the corresponding chalcones. Structures of the synthetic compounds were confirmed by IR, MS, 1H and 13C NMR spectral data.


2014 ◽  
Vol 19 (4) ◽  
pp. 550-557 ◽  
Author(s):  
Ellen M Henderson ◽  
Margaret Fletcher

Evidence-based practice (EBP) is challenging for most nurses due to the time constraints of caring for patients and the emerging pressures of a changing health service. To explore these challenges, and thus to establish possible means of overcoming them, three focus groups ( n = 17) with children’s nurses were conducted. Participants were asked how they would define EBP, what the barriers to EBP were, what skills they needed to help access evidence and how they could integrate evidence into everyday practice. Data were analysed thematically and the anticipated themes of definitions of EBP, barriers, education and nursing culture were determined. Important subthemes were personal and employer disengagement, passivity and lack of resource utilisation. Passive use of evidence readily available in patient folders and on the wards was common. It seemed that little consideration was given to how often this evidence was updated. Nurses define their access to evidence as primarily passive in nature. This is reinforced by a lack of ready access to ongoing education and a perceived lack of investment at institutional level in their continued engagement with evidence. Promoting EBP needs to engage more with those ritual and traditional aspects of nursing culture to challenge these perceptions.


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