Synthesis, characterization, crystal structure, DNA and human serum albumin interactions, as well as antiproliferative activity of a Cu(II) complex containing a Schiff base ligand formed in situ from the Cu(II)‐induced cyclization of 1,5‐bis(salicylidene)thiocarbohydrazide

2021 ◽  
Author(s):  
Sidhali U. Parsekar ◽  
Paramita Haldar ◽  
P.K. Sudhadevi Antharjanam ◽  
Manjuri Kumar ◽  
Aditya P. Koley
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Schiff Base Ligand ◽  
Antiproliferative Activity

scholarly journals Development of In Situ Gelling Meloxicam-Human Serum Albumin Nanoparticle Formulation for Nose-to-Brain Application

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 646
Author(s):  
Gábor Katona ◽  
Bence Sipos ◽  
Mária Budai-Szűcs ◽  
György Tibor Balogh ◽  
Szilvia Veszelka ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Nasal Mucosa ◽  
Drug Absorption ◽  
Cell Damage ◽  
Lipid Fraction ◽  
Poloxamer 407 ◽  
Nasal Drug Delivery

The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered in liquid state into the nostril, and to increase the resistance of the formulation against mucociliary clearance by sol-gel transition on the nasal mucosa, as well as to improve drug absorption. Nanoparticle characterization showed that formulations containing 12–15% w/w P407 met the requirements of intranasal administration. The Z-average (in the range of 180–304 nm), the narrow polydispersity index (PdI, from 0.193 to 0.328), the zeta potential (between −9.4 and −7.0 mV) and the hypotonic osmolality (200–278 mOsmol/L) of MEL-HSA nanoparticles predict enhanced drug absorption through the nasal mucosa. Based on the rheological, muco-adhesion, drug release and permeability studies, the 14% w/w P407 containing formulation (MEL-HSA-P14%) was considered as the optimized formulation, which allows enhanced permeability of MEL through blood–brain barrier-specific lipid fraction. Cell line studies showed no cell damage after 1-h treatment with MEL-HSA-P14% on RPMI 2650 human endothelial cells’ moreover, enhanced permeation (four-fold) of MEL from MEL-HSA-P14% was observed in comparison to pure MEL. Overall, MEL-HSA-P14% can be promising for overcoming the challenges of nasal drug delivery.

scholarly journals Crystal Structure and Biological Implications of a Bacterial Albumin Binding Module in Complex with Human Serum Albumin

2004 ◽  
Vol 279 (41) ◽  
pp. 42924-42928 ◽  
Author(s):  
Sara Lejon ◽  
Inga-Maria Frick ◽  
Lars Björck ◽  
Mats Wikström ◽  
Stefan Svensson
Keyword(s):  
Crystal Structure ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Binding

scholarly journals Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate

2018 ◽  
Vol 13 ◽  
pp. 78-82 ◽  
Author(s):  
Akito Kawai ◽  
Keishi Yamasaki ◽  
Taisuke Enokida ◽  
Shuichi Miyamoto ◽  
Masaki Otagiri
Keyword(s):  
Crystal Structure ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure Analysis ◽  
Crystal Structure Analysis

scholarly journals Crystal structure of human serum albumin at 2.5 Å resolution

1999 ◽  
Vol 12 (6) ◽  
pp. 439-446 ◽  
Author(s):  
S. Sugio ◽  
A. Kashima ◽  
S. Mochizuki ◽  
M. Noda ◽  
K. Kobayashi
Keyword(s):  
Crystal Structure ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum

Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)

2009 ◽  
Vol 64 (4) ◽  
pp. 409-414 ◽  
Author(s):  
Hassan Hosseini Monfared ◽  
Majid Nazari ◽  
Peter Mayer ◽  
Mohammad-Ali Kamyabi ◽  
Andrea Erxleben ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Schiff Base Complex ◽  
Redox Process ◽  
Acetonitrile Solution ◽  
Monoclinic Space Group ◽  
Electrochemical Studies ◽  
Cyclic Voltammetric

The in situ formed hydrazone Schiff base ligand (E)-N´-(2-hydroxy-3-methoxybenzylidene)- benzohydrazide (L2−) reacts with bis(acetylacetonato)titanium(IV) oxide in methanol to a mononuclear [Ti(L)(OCH3)(acac)] complex which crystallizes in the monoclinic space group P21/c, a = 18.2786(13), b = 8.2609(5), c = 13.9008(10) Å , β = 96.809(3)° with Z = 4. Cyclic voltammetric experiments of the species in acetonitrile solution reveals a reversible peak at Eo´ = −0.768 V (vs. Ag/AgCl) relating to the TiIV/TiIII redox process.

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