Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

2020 ◽  
Vol 138 (13) ◽  
pp. 50117
Author(s):  
Beatriz Tiemi Morise ◽  
Alexandra Louise Mutch ◽  
Bruna Cambraia Garms ◽  
Rondinelli Donizetti Herculano ◽  
Lisbeth Grøndahl
Keyword(s):  
Acrylic Acid ◽  
Polymeric Matrices ◽  
Scopolamine Butylbromide

scholarly journals Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

2021 ◽  
Vol 14 (3) ◽  
pp. 234
Author(s):  
Moawia M. Al-Tabakha ◽  
Shujaat Ali Khan ◽  
Akram Ashames ◽  
Hamid Ullah ◽  
Kaleem Ullah ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Antiviral Drug ◽  
Safety Evaluation ◽  
Normal Liver ◽  
Histopathological Change ◽  
Ammonium Persulfate ◽  
Controlled Delivery ◽  
Polymeric Matrices ◽  
Liver And Kidney ◽  
Kidney Functions

Conventional formulations of antiviral drug acyclovir have various limitations such as low bioavailability. The current study was aimed at developing polymeric matrices for the controlled delivery of acyclovir using sericin as polymer and acrylic acid (AA) as a monomer. The free radical polymerization technique was used for hydrogel formulation. Briefly, sericin was chemically cross-linked with acrylic acid. N′-N′-methylene bis-acrylamide (MBA) and ammonium persulfate (APS) were used as cross-linker and initiator, respectively. FTIR spectra showed that acyclovir was successfully loaded into sericin hydrogel. SEM micrographs revealed that the outer surface was solid-like and smooth. According to DSC thermograms, the developed polymeric network was thermally stable. Amorphous nature of acyclovir was observed in XRD. The pH of medium and reactants’ concentration affected swelling dynamics and acyclovir release pattern. In addition, drug release occurred through a diffusion-controlled process. Sericin hydrogel suspension was well tolerable up to 3800 mg/kg of rabbits’ body weight. Haematology and serum chemistry results were well within the range signifying normal liver and kidney functions. Similarly, histopathology slides of the rabbit’s vital organs were also in normal condition without causing any histopathological change. It was concluded from the findings that sericin-co-AA polymeric matrices are ideal for the pH-dependent delivery of acyclovir.

Soft ionic liquid based resistive memory characteristics in a two terminal discrete polydimethylsiloxane cylindrical microchannel

2020 ◽  
Vol 8 (38) ◽  
pp. 13368-13374
Author(s):  
Muhammad Umair Khan ◽  
Gul Hassan ◽  
Jinho Bae
Keyword(s):  
Ionic Liquid ◽  
Acrylic Acid ◽  
Sodium Hydroxide ◽  
Sodium Salt ◽  
Resistive Memory ◽  
Cylindrical Microchannel ◽  
Memory Characteristics ◽  
Poly Acrylic Acid

This paper proposes a novel soft ionic liquid (IL) electrically functional device that displays resistive memory characteristics using poly(acrylic acid) partial sodium salt (PAA-Na+:H2O) solution gel and sodium hydroxide (NaOH) in a thin polydimethylsiloxane (PDMS) cylindrical microchannel.

The Role of the Initiator System in the Synthesis of Acidic Multifunctional Nanoparticles Designed for Molecular Imprinting of Proteins

2020 ◽  
Vol 65 (1) ◽  
pp. 28-41
Author(s):  
Marwa Aly Ahmed ◽  
Júlia Erdőssy ◽  
Viola Horváth
Keyword(s):  
Acrylic Acid ◽  
Binding Affinity ◽  
Molecular Imprinting ◽  
Low Temperatures ◽  
Ammonium Persulfate ◽  
Sodium Bisulfite ◽  
Multifunctional Nanoparticles ◽  
High Affinity ◽  
Initiator System

Multifunctional nanoparticles have been shown earlier to bind certain proteins with high affinity and the binding affinity could be enhanced by molecular imprinting of the target protein. In this work different initiator systems were used and compared during the synthesis of poly (N-isopropylacrylamide-co-acrylic acid-co-N-tert-butylacrylamide) nanoparticles with respect to their future applicability in molecular imprinting of lysozyme. The decomposition of ammonium persulfate initiator was initiated either thermally at 60 °C or by using redox activators, namely tetramethylethylenediamine or sodium bisulfite at low temperatures. Morphology differences in the resulting nanoparticles have been revealed using scanning electron microscopy and dynamic light scattering. During polymerization the conversion of each monomer was followed in time. Striking differences were demonstrated in the incorporation rate of acrylic acid between the tetramethylethylenediamine catalyzed initiation and the other systems. This led to a completely different nanoparticle microstructure the consequence of which was the distinctly lower lysozyme binding affinity. On the contrary, the use of sodium bisulfite activation resulted in similar nanoparticle structural homogeneity and protein binding affinity as the thermal initiation.

SYNTHESIS OF STARCH, ACRYLAMIDE, ACRYLIC ACID AND MONTMORILLONITE-BASED SUPERABSORBENT POLYMER COMPOSITE

2019 ◽  
pp. 69-73
Author(s):  
B. A. Holnazarov ◽  
K. K. Turaev ◽  
A. T. Dzhalilov
Keyword(s):  
Acrylic Acid ◽  
Polymer Composite ◽  
Superabsorbent Polymer

Propane Selective Oxidation to Acrylic Acid over Combined Catalysts

2014 ◽  
Vol 32 (6) ◽  
pp. 1022-1026
Author(s):  
Wen FANG ◽  
Qingjie GE ◽  
Jiafeng YU ◽  
Hengyong XU
Keyword(s):  
Acrylic Acid ◽  
Selective Oxidation ◽  
Combined Catalysts ◽  
Propane Selective Oxidation

Synthesis of composite superabsorbent of poly (acrylic acid sodium)/humic acid by using glow discharge electrolysis plasma

2012 ◽  
Vol 29 (4) ◽  
pp. 376
Author(s):  
Jie REN ◽  
Lihong TAO ◽  
Jinzhang GAO ◽  
Yan LI ◽  
Hongwei LIU ◽  
...  
Keyword(s):  
Humic Acid ◽  
Glow Discharge ◽  
Acrylic Acid ◽  
Glow Discharge Electrolysis ◽  
Glow Discharge Electrolysis Plasma ◽  
Poly Acrylic Acid
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