The third vascular route of the inner ear or the canal of Cotugno: Its topographical anatomy, fetal development, and contribution to ossification of the otic capsule cartilage

2020 ◽  
Author(s):  
Yohei Honkura ◽  
Shogo Hayashi ◽  
Hiroshi Abe ◽  
Gen Murakami ◽  
José F. Rodríguez‐Vázquez ◽  
...  
Keyword(s):  
Inner Ear ◽  
Fetal Development ◽  
Otic Capsule ◽  
The Third ◽  
Topographical Anatomy

Adding the Third Dimension to High Resolution MR-Imaging of the Inner Ear: An Answer waiting for a question

2013 ◽  
Vol 185 (S 01) ◽  
Author(s):  
NN Naguib ◽  
NE Nour-Eldin ◽  
T Gruber-Rouh ◽  
T Lehnert ◽  
R Hammerstingl ◽  
...  
Keyword(s):  
High Resolution ◽  
Mr Imaging ◽  
Inner Ear ◽  
The Third ◽  
Third Dimension

Histological Comparative of Kidney of Neonatal Mice Exposed to Silver Nanoparticles During Fetal Development

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Najat F. Mohammed Salih ◽  
Gazwa D. Al-Nakeeb
Keyword(s):  
Silver Nanoparticles ◽  
Fetal Development ◽  
High Dose ◽  
Histopathological Analysis ◽  
Histological Changes ◽  
Newborn Mice ◽  
The Third ◽  
Tubular Necrosis ◽  
Neonatal Kidney ◽  
Glomerular Tuft

This study aimed to compare the histological changes in the neonatal kidney after their mothers exposed to different doses of silver nanoparticles colloidal solution (AgNPs) during the three stages of pregnancy. Pregnant Swiss albino mice (n=60) were randomly divided into three treated groups. They were intraperitoneally injected with AgNPs for 7 days during each stage of the gestational period. The newborn mice were sacrificed immediately after the birth, and the kidneys were being collected for histopathological analysis. The results showed that the AgNPs caused histological changes in the neonatal kidneys; vacuolation of some renal vesicles and cortical tubules, cystic tubular dilation, glomerular tuft shrinkage, and focal tubular necrosis in the first week-dose exposed pregnant. Disintegrating of immature glomeruli, distention of Bowman’s space of mature glomeruli, tubular necrosis, loss of renal parenchyma, medullar tubules containing hyaline casts, and subcapsular haemorrhage in the second week-dose exposed pregnant. Massive hypercellularity in the deeper part of the renal cortex, cortical and medullary tubules dilation, atrophy of subcapsular immature tubules, cortical cyst formation, glomerular tuft necrosis, dilation of Bowman’s space with evidence of crescent formation, and medullar portion replaced by scant loose connective tissue containing few numbers of tubules the third week-dose exposed pregnant. The results showed that the AgNPs has more negative effects on the kidney development at the third week-high dose and comparing the histological changes in the neonatal kidney were appeared in a time-depended manner and in a dosedepended manner. More researches must be carried out to obtain better understanding of AgNPs toxicity on fetal development and its ability as a teratogenic agent to induce external and internal abnormalities in the fetus.

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

Development ◽  
1989 ◽  
Vol 105 (1) ◽  
pp. 131-136 ◽  
Author(s):  
D.G. Wilkinson ◽  
S. Bhatt ◽  
A.P. McMahon
Keyword(s):  
Inner Ear ◽  
Expression Pattern ◽  
Purkinje Cells ◽  
Fetal Development ◽  
Early Stage ◽  
Multiple Roles ◽  
High Level Expression ◽  
Dynamic Pattern ◽  
Mouse Embryogenesis ◽  
High Level

The FGF-related proto-oncogene int-2 is implicated in mouse embryogenesis, since it is expressed in specific tissues during gastrulation and neurulation (Wilkinson et. al. 1988). Here, we describe the expression of this gene during subsequent fetal development, int-2 transcripts are restricted to Purkinje cells in the cerebellum and to regions of the developing retina containing early-stage differentiating cells. This high level expression is not detected in the mature cerebellum or retina. In addition, int-2 RNA is detected in the mesenchyme of the developing teeth and in sensory regions of the inner ear. This complex and dynamic pattern suggests multiple roles of this proto-oncogene during fetal development of the mouse.

scholarly journals Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere

2010 ◽  
Vol 341 (2) ◽  
pp. 499-509 ◽  
Author(s):  
Nadja Makki ◽  
Mario R. Capecchi
Keyword(s):  
Inner Ear ◽  
Lineage Tracing ◽  
Direct Role ◽  
The Third

Central projections of the lagena (the third otolith endorgan of the inner ear) in the pigeon

2008 ◽  
Vol 40 (3) ◽  
pp. 167-177 ◽  
Author(s):  
V. I. Khorevin
Keyword(s):  
Inner Ear ◽  
Central Projections ◽  
The Third

Hyaluronate production by the inner ear during otic capsule and perilymphatic space formation

1987 ◽  
Vol 8 (5) ◽  
pp. 265-272 ◽  
Author(s):  
Joseph R. McPhee ◽  
Thomas R. Van De Water ◽  
Hung-Xi Su
Keyword(s):  
Inner Ear ◽  
Otic Capsule ◽  
Perilymphatic Space

Cerebellar Projections of the Lagena (the Third Inner Ear Otolith Endorgan) in the Pigeon

2010 ◽  
Vol 42 (1) ◽  
pp. 25-30 ◽  
Author(s):  
V. I. Khorevin
Keyword(s):  
Inner Ear ◽  
The Third

Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat

Development ◽  
1991 ◽  
Vol 113 (2) ◽  
pp. 455-470 ◽  
Author(s):  
C.S. von Bartheld ◽  
S.L. Patterson ◽  
J.G. Heuer ◽  
E.F. Wheeler ◽  
M. Bothwell ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mrna Expression ◽  
Inner Ear ◽  
Ganglion Cells ◽  
Afferent Fiber ◽  
Secretory Cells ◽  
Nerve Growth ◽  
The Third ◽  
Pillar Cells

The expression of nerve growth factor receptors (NGFRs) was studied in the developing inner ear with in situ hybridization in chick embryos and with immunocytochemistry in rat embryos to determine sites of possible functions of NGF or NGF-like molecules in inner ear development. NGFR expression in the chick otocyst and acoustic ganglion is compared with epithelial differentiation and the onset of afferent innervation as determined with fluorescent carbocyanine tracers. In the inner ear of the chick embryo, NGFR mRNA expression shows an alternating pattern in mesenchymal and epithelial tissues. NGFR mRNA is heavily expressed in the mesenchyme surrounding the otocyst (E2-3), ceases at E3-5, and reappears in a thin layer of mesenchymal cells surrounding the membraneous epithelia (E5-13). In the otocyst epithelium, NGFR mRNA expression develops in one anterior and one posterior focus at E3-4.5. NGFR mRNA is expressed in the primordia of the ampullary cristae (E5-7) and possibly the anlage of the utricle; label transiently concentrates in the planum semilunatum of the cristae ampullares and in superior portions of the semicircular canals at E9, but is not seen in differentiating hair cells. In the acoustic ganglion, NGFR mRNA expression begins at E4; at the same time, the first peripheral acoustic nerve processes penetrate the otic epithelium (E4-4.5). The acoustic ganglia remain weakly NGFR mRNA-labeled in the posthatch animal. In the rat embryo, NGFR immunoreactivity is present in the auditory placode at E9, in the periotic mesenchyme at E9-10, and in the medial half of the otocyst at E10-11. At E12, epithelial NGFR expression becomes restricted anteriorly and posteriorly in a pattern similar to that of the chick otocyst and ceases at E13. NGFR immunoreactivity appears transiently in pillar cells of the cochlea in the third week of gestation. NGFR and NGFR mRNA is expressed after E11 in the acoustic ganglia. While NGFR transcripts are expressed in the cochlear ganglion cell bodies, NGFR protein becomes restricted to neuronal processes by the third week of gestation. The vestibular, but not the cochlear (spiral) ganglia remain NGFR-labeled in the adult rat. Onset of NGFR mRNA expression in the acoustic ganglion during the period of afferent fiber ingrowth into the otocyst epithelium is consistent with the hypothesis that NGF-like molecules may have a neurotrophic function for acoustic ganglion cells. Transient expression of NGFRs in secretory cells of the vestibular endorgan and pillar cells in the organ of Corti implicate a role for neurotrophins in the differentiation of these epithelial cell types.

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