scholarly journals Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells

2007 ◽  
Vol 56 (2) ◽  
pp. 531-543 ◽  
Author(s):  
Elena Gonzalez-Rey ◽  
Alejo Chorny ◽  
Nieves Varela ◽  
Francisco O'Valle ◽  
Mario Delgado
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Therapeutic Effect ◽  
Collagen Induced Arthritis ◽  
Down Regulation

Repeated Gamma Irradiation Attenuates Collagen-Induced Arthritis via Up-regulation of Regulatory T Cells but not by Damaging Lymphocytes Directly

2010 ◽  
Vol 174 (3) ◽  
pp. 313-324 ◽  
Author(s):  
Hiroko Nakatsukasa ◽  
Mitsutoshi Tsukimoto ◽  
Akihiro Tokunaga ◽  
Shuji Kojima
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Gamma Irradiation ◽  
Collagen Induced Arthritis

scholarly journals Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142972 ◽  
Author(s):  
C. Henrique Alves ◽  
Julia L. Ober-Blöbaum ◽  
Inge Brouwers-Haspels ◽  
Patrick S. Asmawidjaja ◽  
Adriana M. C. Mus ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Regulatory T Cells ◽  
Collagen Induced Arthritis ◽  
Specific Deletion

Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer

2011 ◽  
Vol 51 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Chao-Hsu Li ◽  
Wen-Hong Kuo ◽  
Wen-Chun Chang ◽  
Su-Cheng Huang ◽  
King-Jen Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
T Lymphocytes ◽  
Regulatory T Cells ◽  
Cytotoxic T Lymphocytes ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Down Regulation

scholarly journals Helminth Antigens Enable CpG-Activated Dendritic Cells to Inhibit the Symptoms of Collagen-induced Arthritis through Foxp3+ Regulatory T Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40356 ◽  
Author(s):  
Franco Carranza ◽  
Cristian Roberto Falcón ◽  
Nicolás Nuñez ◽  
Carolina Knubel ◽  
Silvia Graciela Correa ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Collagen Induced Arthritis

Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+CD25+ regulatory T cells

2010 ◽  
Vol 88 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Ting-Yu Wang ◽  
Jun Li ◽  
Chang-Yu Li ◽  
Yong Jin ◽  
Xiong-Wen Lü ◽  
...  
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Con A ◽  
Collagen Induced Arthritis ◽  
Foxp3 Mrna ◽  
Tgf Β1

This study was to investigate the effect of leflunomide on the immunosuppressive CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) in collagen-induced arthritis (CIA) rats. CIA was induced by collagen type II in Wistar rats. Immunofluorescence flow cytometry and RT-PCR were used to determine the proportion of CD4+CD25+ Tregs and the expression of Foxp3 mRNA, respectively. Proliferation of T lymphocytes was assayed with MTT reagent, and the level of transforming growth factor β1 (TGF-β1) in the supernatant of concanavalin A (Con A)-induced T lymphocytes was determined by ELISA kit. Our investigations demonstrated that inhibition of arthritis by leflunomide was related to changes in CD4+CD25+ Tregs. In addition, A771726, which is the active metabolite of leflunomide, promoted the differentiation of spleen lymphocytes into CD4+CD25+ Tregs, increased antiinflammatory cytokine TGF-β1 secretion, and adjusted the activity of Con A-induced lymphocytes in vitro.

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