Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint

This study aimed to evaluate the effect of intraarticular injection with platelet-rich plasma on knee osteoarthritis. A total of 250 patients with stages I–III osteoarthritis from December 2018 to June 2020 were included in this study. All the patients had received autologous PRP injection (3 ml) into the affected knee joint every week for totally 3 injections. The VAS score and WOMAC index were used to evaluate knee function before and at 3 days, 1 month, and 3 months after injection. A total of 250 patients were enrolled in this study, including 130 patients in the PRP group and 120 patients in the control group. The content of platelets in PRP of patients in the PRP group was 958.0 ± 283.1 × 109/L. The VAS score and WOMAC index of patients in the PRP group before treatment were not significantly different from those in the control group. At 3 days, 1 month, and 3 months after PRP treatment, the VAS score and WOMAC index of the PRP group were significantly lower than those of the control group. PRP is effective in treatment of knee osteoarthritis. The pain symptoms can be alleviated at 3 days after injection.

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Evaluating the efficacy of intra-articular injections of platelet rich plasma (PRP) in rheumatoid arthritis patients and its impact on inflammatory cytokines, disease activity and quality of life.

Current Rheumatology Reviews ◽

10.2174/1573397116666201113090629 ◽

2020 ◽

Vol 16 ◽

Author(s):

Dalia S. Saif ◽

Nagwa N. Hegazy ◽

Enas S. Zahran

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Disease Activity ◽

Inflammatory Cytokines ◽

Platelet Rich Plasma ◽

Joint Inflammation ◽

Monthly Interval ◽

Post Injection ◽

Tnf Α

Background: Among rheumatoid arthritis patients (RA), general disease activity is well regulated by diseasemodifying anti-rheumatic medications (DMARDS), but sometimes local inflammation still persists among a few joints. Adjuvant modern molecular interventions as Platelet Rich Plasma (PRP) with a suggested down regulating effect on inflammatory mediators has a proven effect in management of RA. We aim to evaluate the therapeutic effect of intra-articular PRP versus steroid in RA patients and their impact on inflammatory cytokines IL1B , TNF α, local joint inflammation, disease activity and quality of life (QL). Methods: Open labeled parallel randomized control clinical trial was carried out on 60 RA patients randomly divided into 2 groups, Group 1: included 30 patients received 3 intra-articular injections of PRP at monthly interval, Group 2: included 30 patients received single intra-articular injection of steroid. They were subjected to clinical, laboratory, serum IL1B and TNF α assessment at baseline and at 3, 6 months post injection. Results: Patients of both groups showed improvements in their scores of evaluating tools at 3months post injection and this improvement was persistent in the PRP group up to 6 months post injection while it was continued only for 3 months in the steroid group. Conclusions: PRP is a safe, effective and useful therapy in treating RA patients who had insufficient response and persistent pain and inflammation in just one or two joints through its down regulating effect on inflammatory cytokines IL1B, TNF α with subsequent improvement of local joint inflammation, disease activity and QL.

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AB0041 Comparison of ultrasound findigs of knee joint synovitis and disease activity in rheumatoid arthritis patients

10.1136/annrheumdis-2001.1006 ◽

2001 ◽

Author(s):

VD Skakic

Keyword(s):

Rheumatoid Arthritis ◽

Knee Joint ◽

Disease Activity ◽

Knee Joint Synovitis

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Longitudinal Changes in Knee Joint Synovial Vascularity in a Rabbit Model of Rheumatoid Arthritis: Quantification Using Power Doppler Ultrasound and Contrast-Enhanced Ultrasound

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2021.03.012 ◽

2021 ◽

Author(s):

Hui Liu ◽

Shuqiang Chen ◽

Chao Huang ◽

Qing Zheng ◽

Yuhong Ye ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Knee Joint ◽

Doppler Ultrasound ◽

Power Doppler ◽

Rabbit Model ◽

Contrast Enhanced Ultrasound ◽

Power Doppler Ultrasound ◽

Longitudinal Changes ◽

Contrast Enhanced

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Predictors of rheumatoid arthritis in patients who have monoarthritis in a knee joint

Modern Rheumatology ◽

10.3109/s101650170046 ◽

2001 ◽

Vol 11 (1) ◽

pp. 61-64 ◽

Cited By ~ 1

Author(s):

N. Tanaka ◽

Y. Yamada ◽

H. Sakahashi ◽

E. Sato ◽

S. Ishii

Keyword(s):

Rheumatoid Arthritis ◽

Knee Joint

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Intraarticular Injection of Platelet Rich Plasma in Knee Osteoarthritis

Benha Journal of Applied Sciences ◽

10.21608/bjas.2020.135905 ◽

2021 ◽

Vol 5 (1) ◽

pp. 1-11

Author(s):

M.K. AboElenein ◽

M.G. Alashhab ◽

W.A. Kandil ◽

A.A. Ahmed

Keyword(s):

Knee Osteoarthritis ◽

Platelet Rich Plasma ◽

Intraarticular Injection

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Hope, Hype, Hurdles & Future Perspective for PRP, PRP versus Hyaluronic Acid Injection in Osteoarthritis of Knee: A Review Article.

Biologic Orthopedics Journal ◽

10.22374/boj.v2i1.6 ◽

2020 ◽

Vol 2 (1) ◽

pp. e1-e12

Author(s):

Ashok Kumar ◽

Anikait Ghosh Kadamb ◽

Krish Ghosh Kadamb

Keyword(s):

Hyaluronic Acid ◽

Knee Joint ◽

Platelet Rich Plasma ◽

Future Perspective ◽

Osteoarthritis Of The Knee ◽

Stiff Knee ◽

Injection Interval ◽

One Year

BackgroundComparative studies of platelet-rich plasma (PRP) and hyaluronic acid show variable results. PurposeA review was conducted to understand the current role of PRP and its efficacy versus hyaluronic acid in osteoarthritis (OA) of the knee joint. MethodsOut of 170 identified studies, 14 studies involving 1575 patients with 637 males and 938 females were selected based on PRISMA flow chart guidelines and were analyzed for the study. ResultsA standard PRP regimen consisting of 2–3 intra-articular injections (IA) of 4–6 mL of leucocyte poor PRP at 1–2 weekly intervals provides a better result than HA during the first 3–6 months, and which may continue up to one year. PRP and HA may have synergistic effect; pain and swelling are the two most com-mon complications with PRP, the incidence is more with leucocyte rich PRP (LP-PRP) and intra-osseous PRP treatment.ConclusionPRP provides hope and is more effective than hyaluronic acid in pain relief and improving the quality of life in mild to moderate osteoarthritis of the knee joint. However, hype, that is effective in all, irrespective of grades of OA, mal-aligned or stiff knee, ligamentous laxity, and can avoid joint replacement is a big hindrance in establishing it as a preferred treatment in OA knee. The author follows the above-mentioned PRP regimen; and recommends to combine leucocyte poor PRP with HA for IA injections & with LP-PRP injections along with the two most common painful points (medial collateral ligament, pesanisernius) in a highly painful OA knee. PRP may not address extra-articular causes of knee pain (mal-alignment, muscle wasting, tendinosis), should be corrected for optimum outcome. Contact sports, running, exercises putting pressure on knee and NSAID should be avoided during PRP treatment. Also, more randomized controlled trials are required to further standardize the PRP preparation, administration, injection interval & proper documentation of efficacy and complications in the regenerative registry.

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