High fat diet-Induced obesity alters vitamin D metabolizing enzyme expression in mice

BioFactors ◽  
2015 ◽  
Vol 41 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Jeong Min Park ◽  
Chan Yoon Park ◽  
Sung Nim Han
2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
O. Merino ◽  
R. Sánchez ◽  
B. M. Gregorio ◽  
F. J. Sampaio ◽  
J. Risopatrón

Obesity has adverse effects on male fertility and usually is diagnosed with a prevalence of vitamin D deficiency (VD-). Discussion on the impact of obesity/VD- on sperm function has been limited. This study analyzed the effects of diet-induced obesity/VD- on viability and plasma membrane integrity (PMI), superoxide anion (O2-) level, and DNA fragmentation (DNAfrag) in sperm Sprague-Dawley rats. The males were randomized into four groups and fed for a period of 12 weeks: G1: control diet with vitamin D (C/VD+), G2: control diet without vitamin D (C/VD-), G3: high-fat diet with vitamin D (HF/VD+), and G4: high-fat diet without vitamin D (HF/VD-). Sperm function parameters were analyzed by flow cytometry. PMI percentages and O2- levels were not affected by any of the diets. DNA fragmentation was increasing significantly (p<0.05) in the spermatozoa of animals with diets vitamin D deficient (G2) and diet-induced obesity (G4). Our results allow us to point out that diet-induced obesity and VD- produce greater damage in DNA sperm of rats. The use of nutraceuticals containing vitamin D could be reducing the risk of fragmentation of DNA in spermatozoa.


2019 ◽  
Vol 13 (6) ◽  
pp. 36-43
Author(s):  
Seyed Javad Mirghani ◽  
Mohammad Ali Azarbayjani ◽  
Maghsood Peeri ◽  
Abbasali keshtkar ◽  
◽  
...  

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Chan Yoon Park ◽  
Yongho Shin ◽  
Jeong-Han Kim ◽  
Shuang Zhu ◽  
Young Sun Jung ◽  
...  

Author(s):  
LC Bollheimer ◽  
H Wobser ◽  
CE Wrede ◽  
A Schäffler ◽  
J Schölmerich ◽  
...  

2013 ◽  
Author(s):  
Maya Ramdas ◽  
Chava Harel ◽  
Natalia Krits ◽  
Michal Armoni ◽  
Eddy Karnieli

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