Surgery alone is adequate treatment for early stage soft tissue sarcoma of the extremity

Background: Prognostic biomarkers are pivotal for adequate treatment decision making. The objective of this study was to determine the added prognostic value of quantitative [18F]FDG-PET features in patients with metastases from soft tissue sarcoma (STS). Methods: Patients with metastases from STS, detected by (re)staging [18F]FDG-PET/CT at Leiden University Medical Centre, were retrospectively included. Clinical and histopathological patient characteristics and [18F]FDG-PET features (SUVmax, SUVpeak, SUVmean, total lesion glycolysis, and metabolic tumor volume) were analyzed as prognostic factors for overall survival using a Cox proportional hazards model and Kaplan–Meier methods. Results: A total of 31 patients were included. SUVmax and SUVpeak were significantly predictive for overall survival (OS) in a univariate analysis (p = 0.004 and p = 0.006, respectively). Hazard ratios (HRs) were 1.16 per unit increase for SUVmax and 1.20 per unit for SUVpeak. SUVmax and SUVpeak remained significant predictors for overall survival after correction for the two strongest predictive clinical characteristics (number of lesions and performance status) in a multivariate analysis (p = 0.02 for both). Median SUVmax and SUVpeak were 5.7 and 4.9 g/mL, respectively. The estimated mean overall survival in patients with SUVmax > 5.7 g/mL was 14 months; otherwise, it was 39 months (p < 0.001). For patients with SUVpeak > 4.9 g/mL, the estimated mean overall survival was 18 months; otherwise, it was 33 months (p = 0.04). Conclusions: In this study, SUVmax and SUVpeak were independent prognostic factors for overall survival in patients with metastases from STS. These results warrant further investigation of metabolic imaging with [18F]FDG-PET/CT in patients with metastatic STS.

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Do children, adolescents, and young adults with soft tissue sarcoma benefit from early detection of recurrences? Results of a population-based study.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.9573 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 9573-9573

Author(s):

Tobias M. Dantonello ◽

Peter Winkler ◽

Stefanie Kube ◽

Thekla von Kalle ◽

Daniel Kosztyla ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Early Stage ◽

Clinical Signs ◽

Population Based ◽

Primary Therapy ◽

Asymptomatic Group ◽

Population Based Study ◽

Asymptomatic Patients

9573 Background: Most patients with pediatric soft tissue sarcoma (PSTS) achieve a 1st remission with primary therapy, but recurrences are frequent and drive mortality. Relapse detection (RD) is the foundation of post-treatment surveillance. The rationale for frequent follow-up investigations is RD in an early stage with better salvage options. There is however little evidence regarding the value of early asymptomatic RD and it was not investigated by any larger or population-based study in PSTS. We determined whether early radiographic RD in asymptomatic patients improves post-relapse outcome. Methods: Patients aged < 18 years at first reference-reviewed PSTS-diagnosis registered with CWS were enrolled if a 1st relapse occurred between 1/2003 and 7/2010. The methods of RD and their impact on outcome were evaluated. The data were correlated with the German Childhood Cancer Registry (GCCR), which receives all information about cancer patients < 18 years. Results: 235 patients from Germany (n = 212) and Sweden/Switzerland (n = 23) were eligible. In 2010 all German PSTS-patients were registered both with the GCCR and CWS. The most common PSTS-histiotypes were embryonal (n = 76) and alveolar (n = 74) rhabdomyosarcoma. 156 patients had primary nonmetastatic PSTS. The median time to relapse diagnosis (TTRD) was 1.4 years. 118 recurrences were locoregional, 38 combined and 79 metastatic. In 229 patients, the methods leading to RD could be evaluated. 139 recurrences were detected because of clinical signs and symptoms, primarily observed by patients and/or parents in 72%. 90 RDs were radiographic in asymptomatic patients. TTRD did not differ between symptomatic and asymptomatic patients. As of 12/2011, 77/235 patients are currently alive with a median follow-up of 5.4 years. Overall survival from primary surgery at 3-, 5-, and 10-years for all 235 patients was 49%, 34% and 22%. It was 43%, 29% and 23% for the symptomatic and 59%, 40% and 21% for the asymptomatic group (p = 0.05). Conclusions: In this series, early radiographic RD in asymptomatic PSTS-patients had no significant impact on TTRD or post-relapse survival, although asymptomatic patients tended to survive longer.

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Morphological Examination of a Herpes-type Virus Indigenous for Tree Shrews

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100067790 ◽

1970 ◽

Vol 28 ◽

pp. 160-161

Author(s):

J. P. Brunschwig ◽

R. M. McCombs ◽

R. Mirkovic ◽

M. Benyesh-Melnick

Keyword(s):

Electron Microscopy ◽

Soft Tissue ◽

Chick Embryo ◽

Soft Tissue Sarcoma ◽

Cell Cultures ◽

Tree Shrew ◽

Type Virus ◽

Morphological Examination ◽

Tree Shrews ◽

Embryo Cells

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.

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