Synthesis and Cytotoxic Activity of Hexahydro‐1,3,5‐triazine Derivatives through Ring Condensation

2021 ◽  
Author(s):  
Song Mi Bae ◽  
Sung Young Kang ◽  
Ju Hyun Song
Keyword(s):  
Cytotoxic Activity ◽  
Triazine Derivatives ◽  
Ring Condensation

scholarly journals Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3948
Author(s):  
Zofia Bernat ◽  
Anna Szymanowska ◽  
Mateusz Kciuk ◽  
Katarzyna Kotwica-Mojzych ◽  
Mariusz Mojzych
Keyword(s):  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Chemotherapy ◽  
Cytotoxic Effect ◽  
Therapeutic Agents ◽  
Tumor Cell Lines ◽  
Anticancer Properties ◽  
Triazine Derivatives ◽  
Micromolar Range

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.

scholarly journals Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)

2014 ◽  
Vol 22 (1) ◽  
Author(s):  
Mohammad K Mohammadi ◽  
Omidreza Firuzi ◽  
Mehdi Khoshneviszadeh ◽  
Nima Razzaghi-Asl ◽  
Saghi Sepehri ◽  
...  
Keyword(s):  
Molecular Docking ◽  
B Cell ◽  
Cytotoxic Activity ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Triazine Derivatives

Synthesis and Cytotoxic Activity of Halogen-Containing Dinitromethyl-1,3,5-triazine Derivatives

2004 ◽  
Vol 38 (8) ◽  
pp. 411-419 ◽  
Author(s):  
A. A. Gidaspov ◽  
V. V. Bakharev ◽  
E. V. Kachanovskaya ◽  
E. A. Kosareva ◽  
M. V. Galkina ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Triazine Derivatives

Synthesis of New Heteroaryl Substituted Morpholine Tagged Triazines and Evaluation of their Cytotoxic Activity

2018 ◽  
Vol 15 (2) ◽  
pp. 181-192
Author(s):  
Sivaprasad Kasturi ◽  
Sujatha Surarapu ◽  
Srinivas Uppalanchi ◽  
Hasitha Shilpa Anantaraju ◽  
Shubham Dwivedi ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Chlorine Atom ◽  
Hek293 Cell ◽  
Coupling Reactions ◽  
Stille Coupling ◽  
Thermal Displacement ◽  
Nucleophilic Displacement ◽  
Triazine Derivatives ◽  
Ht 29

Background: In the present study, new triazine derivatives 3, 4, 5, 6, 8 and 10 were synthesized starting from readily available cyanuric chloride 1 via nucleophilic displacement with morpholine followed by Suzuki or Stille coupling reactions and then the thermal displacement of chlorine atom with diverse substituted amines. Methods: All synthesized compounds were screened for their cytotoxic activity against HT-29, MDA-MB-231, and HEK293 cell lines. Results and Conclusion: Compounds 6a (IC50 (µM): 0.32 for HT-29 and 2.92 for MDA-MB-231) and 8c (IC50 (µM): 1.40 for HT-29 and 1.60 for MDA-MB-231) have been identified and compared with Doxorubicin and ZSTK474 as the reference standards.

Phytochemical characterization and cytotoxic activity of Iranecio elbursensis Bioss.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
L Shafiee Hanjani ◽  
P Yazdizadeh Shotorbani ◽  
T Asgari ◽  
G Amin ◽  
E Azizi
Keyword(s):  
Cytotoxic Activity

Synthesis and cytotoxic activity of new betulin and betulinic acid esters with conjugated linoleic acid (CLA)

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Wawrzenczyk ◽  
B Tubek ◽  
P Mitula ◽  
K Kempinska ◽  
J Wietrzyk
Keyword(s):  
Linoleic Acid ◽  
Cytotoxic Activity ◽  
Conjugated Linoleic Acid ◽  
Betulinic Acid ◽  
Acid Esters

Unusual Cycloartane Saponins with Cytotoxic Activity from Astragalus stereocalyx Bornm.

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
FN Yalçın ◽  
S Piacente ◽  
A Perrone ◽  
A Capasso ◽  
H Duman ◽  
...  
Keyword(s):  
Cytotoxic Activity

Screening of Venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against tumour cell lines

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
P Taylor ◽  
M Arsenak ◽  
MJ Abad ◽  
Á Fernández ◽  
R Gonto ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Plant Extracts ◽  
Tumour Cell ◽  
Medicinal Plant Extracts ◽  
Tumour Cell Lines
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