Determination of chidamide in rat plasma by LC-MS and its application to pharmacokinetics study

2013 ◽  
Vol 27 (12) ◽  
pp. 1801-1806 ◽  
Author(s):  
Xianqin Wang ◽  
Mengchun Chen ◽  
Congcong Wen ◽  
Qingwei Zhang ◽  
Jianshe Ma
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetics Study

Simultaneous determination of chito-oligosaccharide in rat plasma by LC-MS/MS method: Application to a pharmacokinetics study

2021 ◽  
Author(s):  
Pengpeng Zhang ◽  
Liu Shuai ◽  
Shuang Yang ◽  
Yuanhong Wang ◽  
Ting-Fu Jiang ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Rat Plasma ◽  
Plasma Samples ◽  
Pharmacokinetics Study ◽  
Sensitive Method

A simple and sensitive method for the simultaneous determination of chito-oligosaccharide (COS) with degrees of polymerization（DPs）from 2 to 7 was developed and used for COS quantification in rat plasma. Samples...

Determination of newly synthesized lipoic acid–fasudil dimer in rat plasma by LC-MS/MS and its application to pharmacokinetics study

2014 ◽  
Vol 6 (21) ◽  
pp. 8675-8681 ◽  
Author(s):  
Waner Hou ◽  
Guanghui Liu ◽  
Xiuman Sun ◽  
Zhiyong Xie ◽  
Rongbiao Pi ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Lipoic Acid ◽  
Internal Standard ◽  
Rat Plasma ◽  
Pharmacokinetics Study

The aim of the present work was to develop and validate an LC-MS/MS method with electrospray ionization (ESI) for the quantification of lipoic acid–fasudil dimer (L–F 001), a novel multi-functional neuroprotective drug in rat plasma, using tetrahydropalmatine as an internal standard.

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