In vitrometabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age

2016 ◽  
Vol 31 (2) ◽  
pp. e3786 ◽  
Author(s):  
Sabrin Fuad Salmin ◽  
Marie-Chantal Giroux ◽  
Pascal Vachon ◽  
Francis Beaudry
Keyword(s):  

The paper describes the role played by mass spectrometry in structural studies of molluscicidal saponins from a plant; the adducts formed between 7,12-dimethylbenz[a]anthracene and nucleic acids upon tissue culture with rat liver; and the G2 factor, the first natural mitotic hormone that regulates cell proliferation.


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