Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

2019 ◽  
Vol 33 (4) ◽  
pp. e4457 ◽  
Author(s):  
Ziwen Yuan ◽  
Lijia Zhong ◽  
Yongli Hua ◽  
Peng Ji ◽  
Wanling Yao ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Blood Stasis ◽  
Angelica Sinensis ◽  
Metabolomics Study ◽  
Processed Products

Chinese Herbal Medicines for Promoting Blood Circulation and Removing Blood Stasis in Preventing Deep Venous Thrombosis after Total Hip Arthroplasty: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 23 ◽  
Author(s):  
Hetao Huang ◽  
Jianke Pan ◽  
Yanhong Han ◽  
Lingfeng Zeng ◽  
Guihong Liang ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Western Medicine ◽  
Blood Circulation ◽  
Meta Analysis ◽  
Blood Stasis ◽  
Herbal Medicines ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Chinese Herbal

Aim and Objective: To evaluate the efficacy and safety of Chinese herbal medicines for promoting blood circulation and removing blood stasis (PBCRBSM) in preventing deep venous thrombosis (DVT) after total hip arthroplasty (THA). Materials and Methods: The Databases were searched for studies comparing the preventive abilities of PBCRBSM and Western medicine, such as low molecular weight heparin (LMWH), rivaroxaban, and aspirin, as well as for randomized controlled trials on DVT after THA. Data were analyzed using RevMan 5.3 software. Results: A total of 3254 randomized controlled trials were included, including 1630 cases in the experimental group and 1624 cases in the control group. Meta-analysis showed that compared with Western medicine, PBCRBSM reduced the incidence of DVT (OR=0.38, 95% CI [0.30, 0.48], P < 0.001); prolonged activated partial thromboplastin time (APTT) (SMD=0.44, 95% CI [0.35, 0.53], P < 0.001); reduced D-dimer (SMD=-0.75, 95% CI [-0.84，-0.65], P < 0.001), FIB (SMD=-0.61, 95% CI [-0.72, -0.50], P < 0.001), blood viscosity (P<0.01), circumference difference in lower extremities (P<0.01), venous blood flow velocity (SMD=0.97, 95% CI [0.77, 1.16], P < 0.001), and drainage volume (SMD=-1.53, 95% CI [-1.71, -1.35], P < 0.001); and reduced adverse reactions (OR = 0.32, 95% CI [0.19, 0.56], P < 0.001). There was no significant difference in prolonging prothrombin time (PT) between traditional Chinese medicine and Western medicine (SMD = 0.07, 95% CI [-0.0.01). 3, 0.16], P > 0.05. Conclusion: PBCRBSM is an effective method for preventing DVT after THA and has fewer adverse effects.

scholarly journals Clinical Overview of Prescription of Promoting Blood Circulation and removing blood stasis in Treating Diabetic Nephropathy

2021 ◽  
Vol 714 (3) ◽  
pp. 032059
Author(s):  
Runxi Wang ◽  
Chunhong Tian ◽  
Yuexuan Liu ◽  
Qianye Lou ◽  
Mengjie Yang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Blood Circulation ◽  
Blood Stasis ◽  
Clinical Overview

scholarly journals Comparison of mechanisms and efficacies of five formulas for improving blood circulation and removing blood stasis

2021 ◽  
Vol 4 (2) ◽  
pp. 144-158
Author(s):  
L.I. Jinxia ◽  
Z.H.O.U. Xiaoqing ◽  
Z.H.E.N.G. Caixing ◽  
L.A.I. Lina ◽  
L.I. Ling
Keyword(s):  
Blood Circulation ◽  
Blood Stasis

scholarly journals Advances in Clinical Research on Prevention and Treatment of Diabetic Nephropathy by Jingfang of Promoting Blood Circulation and Removing Blood Stasis

2019 ◽  
Vol 677 ◽  
pp. 032086
Author(s):  
Xiaobing Li ◽  
Wen Liu ◽  
Xiao Wang ◽  
Mingming Huang ◽  
Qing Shi ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Clinical Research ◽  
Blood Circulation ◽  
Blood Stasis ◽  
Prevention And Treatment

scholarly journals Chinese Herb and Formulas for Promoting Blood Circulation and Removing Blood Stasis and Antiplatelet Therapies

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yue Liu ◽  
Hui-Jun Yin ◽  
Da-zhuo Shi ◽  
Ke-ji Chen
Keyword(s):  
Acute Coronary Syndromes ◽  
Blood Circulation ◽  
Adverse Reactions ◽  
Chinese Herb ◽  
Blood Stasis ◽  
Bleeding Risk ◽  
Blood Stasis Syndrome ◽  
The World ◽  
Close Relationship ◽  
Coronary Syndromes

Atherothrombosis, which directly threatens people's health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the blood stasis syndrome and promoting blood circulation and removing blood stasis is the most active field of research of integration of traditional and western medicine in China. Blood-stasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting blood circulation and removing blood stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting blood circulation and removing blood stasis and is to be deeply discussed in further research.

scholarly journals Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Min Ho Cha ◽  
Min Jung Kim ◽  
Jeeyoun Jung ◽  
Jin Hee Kim ◽  
Myeong Soo Lee ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Blood Circulation ◽  
Blood Stasis ◽  
Partial Least Square ◽  
Least Square ◽  
Plasma Metabolites ◽  
Metabolomic Analysis ◽  
Analysis Model ◽  
Traditional Korean Medicine ◽  
Purple Coloration

Blood stasis (BS) is characterized as a disorder of blood circulation. In traditional Korean medicine (TKM), it is viewed as a cause factor of diseases such as multiple sclerosis and stroke. This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns. Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled. Metabolic profiling was performed using UPLC-MS. The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern. Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model(P<0.001). Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern. Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.

Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model

2015 ◽  
Vol 166 ◽  
pp. 261-269 ◽  
Author(s):  
Peng-ling Li ◽  
Hong-guo Sun ◽  
Yong-li Hua ◽  
Peng Ji ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Angelica Sinensis ◽  
Mice Model ◽  
Metabolomics Study
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