How well do clinical and demographic characteristics predict Patient Health Questionnaire‐9 scores among patients with treatment‐resistant major depressive disorder in a real‐world setting?

Background Accurate reporting of patient symptoms is critical for diagnosis and therapeutic monitoring in psychiatry. Smartphones offer an accessible, low-cost means to collect patient symptoms in real time and aid in care. Objective To investigate adherence among psychiatric outpatients diagnosed with major depressive disorder in utilizing their personal smartphones to run a custom app to monitor Patient Health Questionnaire-9 (PHQ-9) depression symptoms, as well as to examine the correlation of these scores to traditionally administered (paper-and-pencil) PHQ-9 scores. Methods A total of 13 patients with major depressive disorder, referred by their clinicians, received standard outpatient treatment and, in addition, utilized their personal smartphones to run the study app to monitor their symptoms. Subjects downloaded and used the Mindful Moods app on their personal smartphone to complete up to three survey sessions per day, during which a randomized subset of PHQ-9 symptoms of major depressive disorder were assessed on a Likert scale. The study lasted 29 or 30 days without additional follow-up. Outcome measures included adherence, measured by the percentage of completed survey sessions, and estimates of daily PHQ-9 scores collected from the smartphone app, as well as from the traditionally administered PHQ-9. Results Overall adherence was 77.78% (903/1161) and varied with time of day. PHQ-9 estimates collected from the app strongly correlated (r=.84) with traditionally administered PHQ-9 scores, but app-collected scores were 3.02 (SD 2.25) points higher on average. More subjects reported suicidal ideation using the app than they did on the traditionally administered PHQ-9. Conclusions Patients with major depressive disorder are able to utilize an app on their personal smartphones to self-assess their symptoms of major depressive disorder with high levels of adherence. These app-collected results correlate with the traditionally administered PHQ-9. Scores recorded from the app may potentially be more sensitive and better able to capture suicidality than the traditional PHQ-9.

Download Full-text

Screening for Major Depressive Disorders in Adolescent Psychiatric Inpatients with the Mood Modules from the Primary Care Evaluation of Mental Disorders and the Patient Health Questionnaire

Psychological Reports ◽

10.2466/pr0.2001.89.2.274 ◽

2001 ◽

Vol 89 (2) ◽

pp. 274-278 ◽

Cited By ~ 3

Author(s):

Geetha Kumar ◽

Anne H. Kim ◽

David Krefetz ◽

Robert A. Steer

Keyword(s):

Primary Care ◽

Major Depressive Disorder ◽

Mental Disorders ◽

Depressive Disorder ◽

Psychiatric Inpatients ◽

Patient Health Questionnaire ◽

Health Questionnaire ◽

Major Depressive ◽

Patient Health ◽

Care Evaluation

The mood modules from the Primary Care Evaluation of Mental Disorders (PRIME-MD) and the Patient Health Questionnaire (PHQ) were administered to 17 (52%) female and 16 (48%) male adolescent (13–17 years old) psychiatric inpatients. The internal consistencies of both were good (KR-20 for PRIME-MD = .80, Cronbach coefficient α for Patient Health Questionnaire = .85). The correlation between the PRIME-MD and Patient Health Questionnaire total scores was .87 ( p < .001) and the point-biserial correlation of both questionnaires' total scores with being diagnosed with a Major Depressive Disorder was .54 ( p < .001). Both mood modules appeared to be equally effective in screening for a Major Depressive Disorder.

Download Full-text

Translation and validation of brief patient health questionnaire against DSM IV as a tool to diagnose major depressive disorder in Indian patients

Journal of Postgraduate Medicine ◽

10.4103/0022-3859.32209 ◽

2007 ◽

Vol 53 (2) ◽

pp. 102 ◽

Cited By ~ 38

Author(s):

PH Kochhar ◽

SS Rajadhyaksha ◽

VR Suvarna

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Patient Health Questionnaire ◽

Health Questionnaire ◽

Major Depressive ◽

Indian Patients ◽

Patient Health ◽

Dsm Iv ◽

Translation And Validation

Download Full-text

Psychometric Properties of the Patient Health Questionnaire-9 Modified for Major Depressive Disorder in Adolescents

Journal of Child and Adolescent Psychopharmacology ◽

10.1089/cap.2018.0112 ◽

2019 ◽

Vol 29 (1) ◽

pp. 34-40 ◽

Cited By ~ 6

Author(s):

Aiswarya Laks Nandakumar ◽

Jennifer L. Vande Voort ◽

Paul A. Nakonezny ◽

Scott S. Orth ◽

Magdalena Romanowicz ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Psychometric Properties ◽

Patient Health Questionnaire ◽

Health Questionnaire ◽

Major Depressive ◽

Patient Health

Download Full-text

The Patient Health Questionnaire-9 vs. the Hamilton Rating Scale for Depression in Assessing Major Depressive Disorder

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.747139 ◽

2021 ◽

Vol 12 ◽

Author(s):

Simeng Ma ◽

Jun Yang ◽

Bingxiang Yang ◽

Lijun Kang ◽

Peilin Wang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Measurement Accuracy ◽

Rating Scale ◽

Patient Health Questionnaire ◽

Health Questionnaire ◽

Major Depressive ◽

Patient Health ◽

Severity Of Depression ◽

Hamilton Rating Scale

Background: The Hamilton Rating Scale for Depression (HAMD-17) has been used for several decades to assess the severity of depression. Multiple studies have documented defects in this scale and deemed it unsuitable for clinical evaluation. The HAMD-6, which is the abbreviated version of HAMD-17, has been shown to be effective in assessing the core symptoms of depression with greater sensitivity than HAMD-17. And the Patient Health Questionnaire-9 (PHQ-9) is suggested as an effective alternative to the HAMD-17 because of its simplicity and ease-of-use.Methods: Research was completed involving 1,741 participants having major depressive disorder. Cronbach's alpha, intraclass correlation coefficient (ICC) and weighted Kappa analysis was used to determine the reliability of the scales. Pearson correlation analysis and factor analysis were used to analyze validity. Item response theory (IRT) was used to analyze psychological characteristics of items in both the HAMD-17 and PHQ-9.Results: Reliability analysis showed that the Cronbach's alpha of the HAMD-17, HAMD-6 and PHQ-9 were 0.829, 0.764, and 0.893 respectively, and the ICC of the three scales ranged from 0.606 to 0.744. The Kappa score of the consistency of depression severity assessment was 0.248. Validity analysis showed that the PHQ-9 was a single factor structure, and the total score of the scale was strongly correlated with the HAMD-17 (r = 0.724, P < 0.001). The IRT analysis showed that the discrimination parameters of the PHQ-9 were higher than that of the HAMD-17 in all dimensions. The HAMD-6 had the lowest measurement accuracy in distinguishing the severity of depression, while the PHQ-9 had the highest measurement accuracy.Conclusion: Results showed that the PHQ-9 was satisfactory in terms of reliability, validity and distinguishing the severity of depression. It is a simple, rapid, effective and reliable tool which can be used as an alternative to the HAMD-17 to assess the severity of depression.

Download Full-text