scholarly journals Decreased oral Epstein-Barr virus DNA loads in patients with nasopharyngeal carcinoma in Southern China: A case-control and a family-based study

2018 ◽  
Vol 7 (7) ◽  
pp. 3453-3464 ◽  
Author(s):  
Wen-Qiong Xue ◽  
Yong-Qiao He ◽  
Xiao-Yu Liao ◽  
Fang-Fang Li ◽  
Ya-Fei Xu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Case Control ◽  
Barr Virus ◽  
Epstein Barr ◽  
Family Based

scholarly journals Plasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wen-Jie Chen ◽  
Wen-Na Xu ◽  
Hai-Yun Wang ◽  
Xiao-Xia Chen ◽  
Xue-Qi Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Screening Program ◽  
Southern China ◽  
Incidence Rates ◽  
Cox Proportional Hazards ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

Abstract Objective Plasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC development is unclear. Materials and methods A total of 1363 participants seropositive for EBV VCA-IgA and EBNA1-IgA in a community-based NPC screening program in southern China were tested for plasma EBV DNA levels by real-time qPCR between 2008 and 2015. New NPC cases were confirmed by active follow-up approach and linkage to local cancer registry through the end of 2016. Cox proportional hazards regression analysis was performed to calculate the hazard ratios (HRs) for NPC risk with plasma EBV DNA. Results Thirty patients were newly diagnosed during a median 7.5 years follow-up. NPC incidence increased with the plasma EBV DNA load ranging from 281.46 to 10,074.47 per 100,000 person-years in participants with undetectable and ≥ 1000 copies/ml levels; the corresponding cumulative incidence rates were 1.73 and 50%. Furthermore, plasma EBV DNA loads conferred an independent risk for NPC development after adjustment for other risk factors, with HRs of 7.63 for > 3–999 copies/ml and 39.79 for ≥1000 copies/ml. However, the HRs decreased gradually after excluding NPC cases detected in the first 2 to 3 years and became statistically nonsignificant by excluding cases detected during the first 4 years. Conclusion Elevated plasma EBV DNA can predict NPC risk over 3 years. Monitoring plasma EBV DNA can be used as a complementary approach to EBV serological antibody-based screening for NPC.

scholarly journals Smoking can increase nasopharyngeal carcinoma risk by repeatedly reactivating Epstein‐Barr Virus: An analysis of a prospective study in southern China

2019 ◽  
Vol 8 (5) ◽  
pp. 2561-2571 ◽  
Author(s):  
Ting Hu ◽  
Chu‐Yang Lin ◽  
Shang‐Hang Xie ◽  
Geng‐Hang Chen ◽  
Yu‐Qiang Lu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prospective Study ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Barr Virus ◽  
Epstein Barr ◽  
A Prospective Study ◽  
Carcinoma Risk

scholarly journals Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China

Intervirology ◽  
2015 ◽  
Vol 58 (6) ◽  
pp. 386-392
Author(s):  
Guocai Wu ◽  
Xia Liu ◽  
Song Liu ◽  
Jun Shu ◽  
Zhifu Sun ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Early Detection of Nasopharyngeal Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Keiji Tabuchi ◽  
Masahiro Nakayama ◽  
Bungo Nishimura ◽  
Kentaro Hayashi ◽  
Akira Hara
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Early Detection ◽  
Epstein Barr Virus ◽  
Clinical Presentation ◽  
Southern China ◽  
Squamous Cell Carcinomas ◽  
Treatment Results ◽  
Barr Virus ◽  
Associated Malignancy ◽  
Epstein Barr

Nasopharyngeal carcinoma (NPC) is a unique disease with a clinical presentation, epidemiology, and histopathology differing from other squamous cell carcinomas of the head and neck. NPC is an Epstein-Barr virus-associated malignancy with a marked racial and geographic distribution. Specifically, it is highly prevalent in southern China, Southeast Asia, and the Middle East. To date, most NPC patients have been diagnosed in the advanced stage, but the treatment results for advanced NPC are not satisfactory. This paper provides a brief overview regarding NPC, with the focus on the early detection of initial and recurrent NPC lesions.

scholarly journals Role of Epstein-Barr virus in the development of nasopharyngeal carcinoma

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 171-176 ◽  
Author(s):  
Hui Zhang ◽  
Jing Wang ◽  
Dan Yu ◽  
Yan Liu ◽  
Kai Xue ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Ebv Infection ◽  
Micro Rnas ◽  
Total Cancer ◽  
Epstein Barr

AbstractSouthern China experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated. The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The pathophysiology in making of EBV into a cancerogen includes proteins as latent membrane protein 1 (LMPs) and nucleic acids as micro-RNAs. In this paper, we reviewed till date studies focusing on relationship between EBV and nasopharyngeal carcinoma.

Nasopharyngeal Carcinoma, with Emphasis on its Relationship to Epstein-Barr Virus

1997 ◽  
Vol 106 (4) ◽  
pp. 348-356 ◽  
Author(s):  
Mohammad A. Vasef ◽  
Alfio Ferlito ◽  
Lawrence M. Weiss
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Environmental Factors ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Related Factor ◽  
Epithelial Tumor ◽  
Barr Virus ◽  
Epstein Barr ◽  
Genetic And Environmental Factors

Nasopharyngeal carcinoma (NPC) is an epithelial tumor with a distinct geographic distribution and a characteristic histologic appearance. It is rare in Europe and North America, but it is among the most common cancers in southern China. Genetic predisposition, environmental factors, and Epstein-Barr virus (EBV) all have been associated with the pathogenesis of this tumor. There is an increasing body of evidence that among all these factors, EBV appears to be the strongest and most consistently related factor. According to the current sensitive in situ hybridization methods for the detection of EBV-encoded small RNAs (EBER), almost 100% of cases of NPC, irrespective of their histologic subtypes, have demonstrable EBERs in the nuclei of the tumor cells. In this review paper, we discuss the predisposing genetic and environmental factors and the role of EBV in the pathogenesis of this tumor with particular emphasis on the role of EBV.

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