Aim: PD-L1 is an important immune intervention target for lung cancer treatment; however, its clinical significance and biological function in circulating tumor cells (CTCs) of lung cancer need to be explored in depth. Materials & methods: In this study, the CanPatrol method was used to detect three types of CTCs and PD-L1 in 271 lung cancer patients from December 2015 to October 2019. Results: Smoking index, pathological diagnosis and clinical stage are independent influencing factors of PD-L1 expression. The methods that affect the count of CTCs are first-line chemotherapy and targeted therapy; however, there is no difference in the expression of PD-L1 with different treatments. Conclusions: The detection of CTCs and PD-L1 in peripheral blood is helpful for the diagnosis of lung cancer patients.
Clinical significance of circulating tumor cells and tumor markers in the diagnosis of lung cancer
