Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia

2004 ◽  
Vol 22 (4) ◽  
pp. 213-217 ◽  
Author(s):  
Abdulkadir Yildirim ◽  
Konca Altinkaynak ◽  
Hulya Aksoy ◽  
Y. Nuri Sahin ◽  
Fatih Akcay
Keyword(s):  
Superoxide Dismutase ◽  
Uric Acid ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase

Evaluation of the status of salivary antioxidants in dental caries

2019 ◽  
Vol 19 ◽  
Author(s):  
Seyedeh Sareh Hendi ◽  
Mohammad Taghi Goodarzi ◽  
Abbas Moghimbeigi ◽  
Fatemeh Ahmadi-Motamayel
Keyword(s):  
Superoxide Dismutase ◽  
Uric Acid ◽  
Dental Caries ◽  
Glutathione Peroxidase ◽  
Active Group ◽  
Female Group ◽  
Test Results ◽  
Whole Saliva ◽  
The Status ◽  
Student’S T

Background and Aim: Dental caries is one of the most common, communicable and infectious disease worldwide. Oxidative stress may play a role in caries pathogenesis and salivary antioxidants may play a preventive role on dental caries. The aim of this study was to evaluate salivary superoxide dismutase, peroxidase, glutathione peroxidase, catalase and uric acid in dental caries. Material and Method: 100 healthy students in two female and male (50) groups subdivided to caries active and caries free (25) groups. Un-stimulated whole saliva specimens were collected in the morning. Salivary superoxide dismutase, peroxidase, glutathione peroxidase, catalase and uric acid were measured by Spectrophotometric assay. Data were analyzed using Student’s t-test. Results: The results showed that caries active group had higher peroxidase, uric acid, catalase, glutathione peroxidase and lower superoxide dismutase as compared to caries free group. Comparison between males and females, showed lower peroxidase, catalase, uric acid and higher glutathione peroxidase in female group. Conclusion: Caries active group had changed salivary antioxidants levels. So salivary antioxidants may play an important role in caries prevention, formation and progression

Oxidative stress profile during postpartum period in Surti goats

2016 ◽  
Author(s):  
Tanvi D. Manat ◽  
Sandhya S. Chaudhary ◽  
Virendra Kumar Singh ◽  
Sanjay B. Patel ◽  
Kuldeep Kumar Tyagi
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Critical Care ◽  
Uric Acid ◽  
Glutathione Peroxidase ◽  
Postpartum Period ◽  
Reduced Glutathione ◽  
Stress Profile ◽  
Blood Samples

Present study was conducted to investigate postpartum oxidative stress in 20 Surti goats. Blood samples were collected on 0, 7th, 14th, 21st, 30th and 45th days postpartum and analysed for Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), lipid peroxidation (LPO), reduced Glutathione (GSH) and uric acid. SOD differed significantly between 0, 14th and 21st day postpartum. GPx was significantly low on 14th day and then increased significantly (P<0.01) up to 45th day. Significant (P<0.01) difference was observed between days except 0 and 21st. LPO increased significantly (P<0.01) from 0 to 14th day and then decreased non-significantly up to 45th day. Reduced glutathione was significantly (P<0.05) higher on 0 day. Uric acid was lowest on 0 day and highest on 45th day however they were non-significantly different on 7th, 14th, 30th and 45th day. It can be summarized that on 14th day post kidding, the values of SOD, GPx and GSH were lowest while LPO was highest. Uric acid was significantly (P<0.01) low on the day of kidding. Thus it may be concluded that in Surti goats the period from 0 day to 14th day postpartum is most stressful and critical care should be taken during this period. GPx, SOD along with LPO and GSH can be used as marker of stress during postpartum period.

scholarly journals The Relationship Between Antioxidant Enzymes and Lipid Peroxidation in Senescent Rat Erythrocytes

2015 ◽  
pp. 891-896 ◽  
Author(s):  
M. MLADENOV ◽  
M. GOKIK ◽  
N. HADZI-PETRUSHEV ◽  
I. GJORGOSKI ◽  
N. JANKULOVSKI
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Uric Acid ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Complete Information ◽  
Rat Erythrocytes ◽  
Endogenous Antioxidants ◽  
The Relationship

The aim of this study was to gain more complete information about the relationships between some endogenous antioxidants and the malondialdehyde (MDA) as a marker of lipid peroxidation, during D-galactose induced senescence. The activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and the concentrations of uric acid (UA) in plasma and MDA in erythrocyte’s hemolysate, were determined in 15 D-galactose (D-gal), treated rats and compared with 15 placebo. The activity of the erythrocyte’s CAT was found significantly increased due to the senescence. The ratio of the activities of antioxidant enzymes R=SOD/(GPx+CAT) was significantly decreased due to the senescence and negatively correlated with the MDA (ρ=–0.524, p=0.045). The antioxidant enzymes SOD and GPx negatively correlated with the MDA, while CAT displayed no correlation. Further, the UA positively correlated with the ratio of activities of the antioxidant enzymes R=SOD/(GPx+CAT), (ρ=0.564, p=0.029 for senescent rats). Obtained results may contribute to better understanding of the process of D-gal induced senescence in the erythrocytes.

Serum glutathione peroxidase, xanthine oxidase, and superoxide dismutase activities and malondialdehyde levels in patients with Parkinson’s disease

2016 ◽  
Vol 38 (3) ◽  
pp. 425-431 ◽  
Author(s):  
Burcu Gökçe Çokal ◽  
Mustafa Yurtdaş ◽  
Selda Keskin Güler ◽  
Hafize Nalan Güneş ◽  
Ceyla Ataç Uçar ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase

scholarly journals Differences in activities of antioxidant superoxide dismutase, glutathione peroxidase and prooxidant xanthine oxidoreductase/xanthine oxidase in the normal corneal epithelium of various mammals

2007 ◽  
pp. 105-112
Author(s):  
J Kovačeva ◽  
J Pláteník ◽  
M Vejražka ◽  
S Štípek ◽  
T Ardan ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase ◽  
Peroxidase Activity ◽  
Corneal Epithelium ◽  
Guinea Pigs ◽  
Superoxide Dismutase Activity ◽  
Xanthine Oxidoreductase ◽  
Glutathione Peroxidase Activity ◽  
Oxidoreductase Activity

Under normal conditions, antioxidants at the corneal surface are balanced with the production of reactive oxygen species without any toxic effects. Danger from oxidative stress appears when natural antioxidants are overwhelmed leading to antioxidant/prooxidant imbalance. The aim of the present study was to examine the activities of enzymes contributing to the antioxidant/prooxidant balance in normal corneal epithelium of various mammals. The enzyme activities of antioxidant superoxide dismutase and glutathione peroxidase, as well as prooxidant xanthine oxidoreductase/xanthine oxidase were examined using biochemical methods. Results show that superoxide dismutase activity is high in rabbits and guinea pigs, whereas in pigs the activity is low and in cows it is nearly absent. In contrast, glutathione peroxidase activity is high in cows, pigs and rabbits, whereas in guinea pigs the activity is low. As far as prooxidant enzymes are concerned, elevated xanthine oxidoreductase/xanthine oxidase activities were found in rabbits, lower activities in guinea pigs, very low activity in cows and no activity in pigs. In conclusion, the above results demonstrate inter-species variations in activities of enzymes participating in antioxidant/prooxidant balance in the corneal epithelium. It is suggested that the levels of antioxidant and prooxidant enzymes studied in the corneal epithelium might be associated with the diurnal or nocturnal activity of animals. UV rays decompose hydrogen peroxide to damaging hydroxyl radicals and perhaps for this reason large animals with diurnal activity (cow, pig) require more effective peroxide removal (high glutathione peroxidase activity) together with the suppression of peroxide production (low superoxide dismutase activity, low xanthine oxidoreductase activity).

scholarly journals ADULT HEALTHY SMOKERS

2016 ◽  
Vol 23 (07) ◽  
pp. 770-774
Author(s):  
Abdul Raqeeb ◽  
Azhar Memon ◽  
Mona Humaira ◽  
Haji Khan Khoharo
Keyword(s):  
Superoxide Dismutase ◽  
Uric Acid ◽  
Glutathione Peroxidase ◽  
Serum Bilirubin ◽  
P Value ◽  
Chi Square ◽  
Total Blood ◽  
Chi Square Test ◽  
Anti Oxidant ◽  
Student’S T

Objectives: To determine superoxide dismutase (SOD), glutathione peroxidase(GPX), and malondialdehyde (MDA), uric acid and serum bilirubin in healthy adult smokers.Study Design: Case control study. Place and Duration: Liaquat University of Medical andHealth Sciences Hospital. Hyderabad, Sindh from December 2013 - July 2014. Subjects andMethods: 77 smokers and 50 healthy controls were selected through non-probability purposivesampling. Blood glucose, lipids, MDA, antioxidant enzymes (SOD & GPX), serum bilirubin anduric acid (UA) were measured. Data was analyzed on Statistic software 8.1 by student’s t testand Chi square test. The significant p-value was taken at ≤ 0.05. Results: Anti-oxidant enzymes(SOD & GPX), blood lipids, lipid per oxidant marker; the MDA, bilirubin and UA showedstatistically significant differences between smokers and controls (p<0.001). Total blood lipidsand lipid sub fractions were elevated in smokers. MDA in smokers was 3.17±0.91 μmol/mlcompared to 1.15±0.61 μmol/ml (p=0.001) in controls. Smokers showed reduced SOD, GPX,serum bilirubin and UA, was significant (p=0.0001) in comparison to controls. Conclusion:Cigarette smoke is a significant source of oxidative stress. Smoking increases malondialdehydeand reduces superoxide dismutase, glutathione peroxidase, uric acid and bilirubin.

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