Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats

2022 ◽  
Author(s):  
Badrinathan Sridharan ◽  
Venkataseshan Jagannathan ◽  
Nachiappa Ganesh Rajesh ◽  
Pragasam Viswanathan
Keyword(s):  
Vitamin E ◽  
Calcium Oxalate ◽  
Polyacrylic Acid ◽  
Combined Effect ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition

Renal Cell Carcinoma With Intratumoral Calcium Oxalate Crystal Deposition in Patients With Acquired Cystic Disease of the Kidney

2003 ◽  
Vol 127 (2) ◽  
pp. e89-e92
Author(s):  
Nathalie C. Rioux-Leclercq ◽  
Jonathan I. Epstein
Keyword(s):  
Renal Cell Carcinoma ◽  
Calcium Oxalate ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Cystic Disease ◽  
Calcium Oxalate Crystal ◽  
Cell Renal Cell Carcinoma ◽  
Crystal Deposition ◽  
Acquired Cystic Disease

Abstract We describe 2 cases of renal cell carcinoma arising in acquired cystic disease of the kidney (ACDK) in patients with end-stage renal disease undergoing hemodialysis for more than 5 years and provide a brief review of the complications of ACDK. In both cases, abundant calcium oxalate crystals were observed within the tumors. Histologically, one of the tumors was a conventional (clear cell) renal cell carcinoma. The other tumor was a bilateral papillary renal cell carcinoma. Both tumors were high-grade carcinomas with extensive oncocytic (acidophilic) features. Also noted within the kidneys were cysts with atypical papillary hyperplasia. The clinicopathologic findings along with review of the literature suggest a relationship between tumor growth and calcium oxalate crystal deposition in patients undergoing hemodialysis with ACDK.

scholarly journals Case Report of a Fatal Antifreeze Ingestion with a Record High Level and Impressive Renal Crystal Deposition

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Heidi L. Erickson
Keyword(s):  
Case Report ◽  
Ethylene Glycol ◽  
Calcium Oxalate ◽  
Cerebral Edema ◽  
Diethylene Glycol ◽  
Significant Morbidity ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Autopsy Findings ◽  
High Level

Ethylene glycol, methanol, and diethylene glycol are readily available in many household and commercially available products. While these alcohols are relatively nontoxic themselves, their acidic metabolites are toxic and can result in significant morbidity and mortality. Herein we report a lethal case of massive ethylene glycol ingestion in a suicide with a record high level (1254 mg/dL) and images of the histologic examination of the kidneys revealing impressive calcium oxalate crystal deposition. Autopsy findings also showed evidence of mild cerebral edema.

scholarly journals Aluminum Citrate Prevents Renal Injury from Calcium Oxalate Crystal Deposition

2012 ◽  
Vol 23 (12) ◽  
pp. 2024-2033 ◽  
Author(s):  
Lauren M. Besenhofer ◽  
Marie C. Cain ◽  
Cody Dunning ◽  
Kenneth E. McMartin
Keyword(s):  
Calcium Oxalate ◽  
Renal Injury ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition

Periplasmic cuticular calcium oxalate crystal deposition in Dracaena sanderiana

2001 ◽  
Vol 149 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Svoboda V. Pennisi ◽  
Dennis B. McConnell ◽  
Laurie B. Gower ◽  
Michael E. Kane ◽  
T. Lucansky
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Dracaena Sanderiana

Hydroxycitric Acid Inhibits Renal Calcium Oxalate Deposition by Reducing Oxidative Stress and Inflammation

2020 ◽  
Vol 20 (7) ◽  
pp. 527-535 ◽  
Author(s):  
Xiao Liu ◽  
Peng Yuan ◽  
Xifeng Sun ◽  
Zhiqiang Chen
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Calcium Oxalate ◽  
Tubular Injury ◽  
Calcium Oxalate Crystals ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Qrt Pcr ◽  
Hydroxycitric Acid ◽  
Oxalate Crystals

Objective: The study aimed to evaluate the preventive effects of hydroxycitric acid（HCA） for stone formation in the glyoxylate-induced mouse model. Materials and methods: Male C57BL/6J mice were divided into a control group, glyoxylate(GOX) 100 mg/kg group, a GOX+HCA 100 mg/kg group, and a GOX+HCA 200 mg/kg group. Blood samples and kidney samples were collected on the eighth day of the experiment. We used Pizzolato staining and a polarized light microscope to examine crystal formation and evaluated oxidative stress via the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px). Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used to detect the expression of monocyte chemotactic protein-1(MCP-1), nuclear factor-kappa B (NF κ B), interleukin-1 β (IL-1 β) and interleukin-6 (IL-6) messenger RNA (mRNA). The expression of osteopontin (OPN) and a cluster of differentiation-44(CD44) were detected by immunohistochemistry and qRT-PCR. In addition, periodic acid Schiff (PAS) staining and TUNEL assay were used to evaluate renal tubular injury and apoptosis. Results: HCA treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There was significantly less calcium oxalate crystal deposition in mice treated with HCA. Calcium oxalate crystals induced the production of reactive oxygen species and reduced the activity of antioxidant defense enzymes. HCA attenuated oxidative stress induced by calcium oxalate crystallization. HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL- 1 β, and IL-6. In addition, HCA alleviated tubular injury and apoptosis caused by calcium oxalate crystals. Conclusion: HCA inhibits renal injury and calcium oxalate crystal deposition in the glyoxylate-induced mouse model through antioxidation and anti-inflammation.

scholarly journals Calcium oxalate crystal deposition in kidneys of hypercalciuric mice with disrupted type IIa sodium-phosphate cotransporter

2008 ◽  
Vol 294 (5) ◽  
pp. F1109-F1115 ◽  
Author(s):  
Saeed R. Khan ◽  
Patricia A. Glenton
Keyword(s):  
Animal Model ◽  
Calcium Oxalate ◽  
Kidney Stones ◽  
Sodium Phosphate ◽  
Renal Tubules ◽  
Male Mice ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Caox Crystal ◽  
Local Supersaturation

The most common theories about the pathogenesis of idiopathic kidney stones consider precipitation of calcium phosphate (CaP) within the kidneys critical for the development of the disease. We decided to test the hypothesis that a CaP substrate can promote the deposition of calcium oxalate (CaOx) in the kidneys. Experimental hyperoxaluria was induced by feeding glyoxylate to male mice with knockout (KO) of NaPi IIa (Npt2a), a sodium-phosphate cotransporter. Npt2a KO mice are hypercalciuric and produce CaP deposits in their renal tubules. Experimental hyperoxaluria led to CaOx crystalluria in both the hypercalciuric KO mice and the normocalciuric control B6 mice. Only the KO mice produced CaOx crystal deposits in their kidneys, but the CaOx crystals deposited separately from the CaP deposits. Perhaps CaP deposits were not available for a CaOx overgrowth. These results also validate earlier animal model observations that showed that CaP substrate is not required for renal deposition of CaOx and that other factors, such as local supersaturation, may be involved. The absence of CaOx deposition in the B6 mice despite extreme hyperoxaluria also signifies the importance of both calcium and oxalate in the development of CaOx nephrolithiasis.

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