scholarly journals Aluminum Citrate Prevents Renal Injury from Calcium Oxalate Crystal Deposition

2012 ◽  
Vol 23 (12) ◽  
pp. 2024-2033 ◽  
Author(s):  
Lauren M. Besenhofer ◽  
Marie C. Cain ◽  
Cody Dunning ◽  
Kenneth E. McMartin
Keyword(s):  
Calcium Oxalate ◽  
Renal Injury ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition

Kaempferol alleviates calcium oxalate crystal-induced renal injury and crystal deposition via regulation of the AR/NOX2 signaling pathway

Phytomedicine ◽  
2021 ◽  
pp. 153555
Author(s):  
Peng Yuan ◽  
Xifeng Sun ◽  
Xiao Liu ◽  
Georg Hutterer ◽  
Karl Pummer ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Signaling Pathway ◽  
Renal Injury ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition

scholarly journals Citrus Bioflavonoids Ameliorate Hyperoxaluria Induced Renal Injury and Calcium Oxalate Crystal Deposition in Wistar Rats

2015 ◽  
Vol 5 (3) ◽  
pp. 419-427 ◽  
Author(s):  
Sridharan Badrinathan ◽  
Micheal Thomas Shiju ◽  
Ramachandran Arya ◽  
Ganesh Nachiappa Rajesh ◽  
Pragasam Viswanathan
Keyword(s):  
Calcium Oxalate ◽  
Renal Injury ◽  
Wistar Rats ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition

Renal Cell Carcinoma With Intratumoral Calcium Oxalate Crystal Deposition in Patients With Acquired Cystic Disease of the Kidney

2003 ◽  
Vol 127 (2) ◽  
pp. e89-e92
Author(s):  
Nathalie C. Rioux-Leclercq ◽  
Jonathan I. Epstein
Keyword(s):  
Renal Cell Carcinoma ◽  
Calcium Oxalate ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Cystic Disease ◽  
Calcium Oxalate Crystal ◽  
Cell Renal Cell Carcinoma ◽  
Crystal Deposition ◽  
Acquired Cystic Disease

Abstract We describe 2 cases of renal cell carcinoma arising in acquired cystic disease of the kidney (ACDK) in patients with end-stage renal disease undergoing hemodialysis for more than 5 years and provide a brief review of the complications of ACDK. In both cases, abundant calcium oxalate crystals were observed within the tumors. Histologically, one of the tumors was a conventional (clear cell) renal cell carcinoma. The other tumor was a bilateral papillary renal cell carcinoma. Both tumors were high-grade carcinomas with extensive oncocytic (acidophilic) features. Also noted within the kidneys were cysts with atypical papillary hyperplasia. The clinicopathologic findings along with review of the literature suggest a relationship between tumor growth and calcium oxalate crystal deposition in patients undergoing hemodialysis with ACDK.

scholarly journals Case Report of a Fatal Antifreeze Ingestion with a Record High Level and Impressive Renal Crystal Deposition

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Heidi L. Erickson
Keyword(s):  
Case Report ◽  
Ethylene Glycol ◽  
Calcium Oxalate ◽  
Cerebral Edema ◽  
Diethylene Glycol ◽  
Significant Morbidity ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Autopsy Findings ◽  
High Level

Ethylene glycol, methanol, and diethylene glycol are readily available in many household and commercially available products. While these alcohols are relatively nontoxic themselves, their acidic metabolites are toxic and can result in significant morbidity and mortality. Herein we report a lethal case of massive ethylene glycol ingestion in a suicide with a record high level (1254 mg/dL) and images of the histologic examination of the kidneys revealing impressive calcium oxalate crystal deposition. Autopsy findings also showed evidence of mild cerebral edema.

Periplasmic cuticular calcium oxalate crystal deposition in Dracaena sanderiana

2001 ◽  
Vol 149 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Svoboda V. Pennisi ◽  
Dennis B. McConnell ◽  
Laurie B. Gower ◽  
Michael E. Kane ◽  
T. Lucansky
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Dracaena Sanderiana

scholarly journals Metabolic and Network Pharmacological Analyses of the Therapeutic Effect of Grona styracifolia on Calcium Oxalate-Induced Renal Injury

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Chen ◽  
Yachen Si ◽  
Jin Cheng ◽  
Jiarong Ding ◽  
Hongxia Zhao ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Therapeutic Effect ◽  
Renal Injury ◽  
High Performance ◽  
Folk Medicine ◽  
Network Pharmacology ◽  
Control Group ◽  
Protective Effects ◽  
Crystal Deposition ◽  
Flight Mass Spectrometry

Grona styracifolia (Osbeck) Merr. (GS), a popular folk medicine, is clinically applied to treat nephrolithiasis. In this study, a urinary metabolic analysis was performed in a mouse model of renal calcium oxalate (CaOx) crystal deposition to identify the differentially altered metabolites in mice with oxalate-induced renal injury and explore the therapeutic mechanisms of GS against nephrolithiasis. Twenty-four mice were randomly divided into the control, oxalate and GS-treated groups. A metabolomics approach based on ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) was used to analyze the metabolic profiles of the urine samples. In addition, network pharmacology analysis was performed with different databases. As a result, the protective effects of GS were verified by measuring biochemical parameters and detecting crystal deposition. Fifteen metabolites were identified as the differentially altered metabolites in mice with crystal-induced renal injury. Most were involved in amino acid and fatty acid metabolism. Thirteen of these metabolites showed a reversal trend following GS treatment. A component-target-metabolite network was further constructed and nine overlapping target proteins of GS and the differentially altered metabolites were discovered. Among these proteins, the expression of estrogen receptor 2 (ESR2) in renal tissues was significantly down-regulated while androgen receptor (AR) expression was obviously increased in the oxalate group compared with the control group. These changes were reversed by the GS treatment. In conclusion, GS exerts its therapeutic effect by regulating multiple metabolic pathways and the expression of ESR and AR in mice with oxalate-induced renal injury.

Hydroxycitric Acid Inhibits Renal Calcium Oxalate Deposition by Reducing Oxidative Stress and Inflammation

2020 ◽  
Vol 20 (7) ◽  
pp. 527-535 ◽  
Author(s):  
Xiao Liu ◽  
Peng Yuan ◽  
Xifeng Sun ◽  
Zhiqiang Chen
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Calcium Oxalate ◽  
Tubular Injury ◽  
Calcium Oxalate Crystals ◽  
Calcium Oxalate Crystal ◽  
Crystal Deposition ◽  
Qrt Pcr ◽  
Hydroxycitric Acid ◽  
Oxalate Crystals

Objective: The study aimed to evaluate the preventive effects of hydroxycitric acid（HCA） for stone formation in the glyoxylate-induced mouse model. Materials and methods: Male C57BL/6J mice were divided into a control group, glyoxylate(GOX) 100 mg/kg group, a GOX+HCA 100 mg/kg group, and a GOX+HCA 200 mg/kg group. Blood samples and kidney samples were collected on the eighth day of the experiment. We used Pizzolato staining and a polarized light microscope to examine crystal formation and evaluated oxidative stress via the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px). Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used to detect the expression of monocyte chemotactic protein-1(MCP-1), nuclear factor-kappa B (NF κ B), interleukin-1 β (IL-1 β) and interleukin-6 (IL-6) messenger RNA (mRNA). The expression of osteopontin (OPN) and a cluster of differentiation-44(CD44) were detected by immunohistochemistry and qRT-PCR. In addition, periodic acid Schiff (PAS) staining and TUNEL assay were used to evaluate renal tubular injury and apoptosis. Results: HCA treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There was significantly less calcium oxalate crystal deposition in mice treated with HCA. Calcium oxalate crystals induced the production of reactive oxygen species and reduced the activity of antioxidant defense enzymes. HCA attenuated oxidative stress induced by calcium oxalate crystallization. HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL- 1 β, and IL-6. In addition, HCA alleviated tubular injury and apoptosis caused by calcium oxalate crystals. Conclusion: HCA inhibits renal injury and calcium oxalate crystal deposition in the glyoxylate-induced mouse model through antioxidation and anti-inflammation.

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