Increased deep sleep in a medication-free, detoxified female offender with schizophrenia, alcoholism and a history of attempted homicide: effect of concomitant administration of quetiapine and citalopram

Congenital central hypoventilation syndrome (CCHS), which occurs in less than 1 in every 50,000 infants and children, is a rare syndrome first noted in literature by Mellins in 1970. Congenital central hypoventilation syndrome is a condition in which the patient loses the drive to breathe during deep sleep and can mimic many diseases. Until recently, CCHS has largely been a diagnosis of exclusion; fortunately, there is now a genetic test available to confirm the diagnosis.The purpose of this article is to discuss the steps taken to confirm the diagnosis of CCHS. In addition to the history of the disease and clinical manifestations, genetics and prognosis of children with CCHS will be discussed. Two cases are presented for illustration of hospital course and preparation for discharge.

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The Forgotten Female Offender

Crime & Delinquency ◽

10.1177/001112877702300218 ◽

1977 ◽

Vol 23 (2) ◽

pp. 101-102

Author(s):

Ray R. Price

Keyword(s):

Criminal Justice ◽

Criminal Justice System ◽

Justice System ◽

Female Offender ◽

Negative Effects ◽

Female Crime ◽

New Directions ◽

Disparate Treatment ◽

History Of ◽

System Information

Until recently the female offender was generally overlooked by an overwhelmingly male-dominated criminal justice system. Information derived from an extensive search of the literature illustrates the dramatic increase of female crime; it further suggests the potential for modifying the sexist nature of the criminal justice system. Questions are raised about some popular misconceptions pertaining to the data. A review of the history of women's involvement as subjects of the criminal justice system in general, and correction in particular, reveals disparate treatment for men and women throughout that process. Both positive and negative effects of this orientation are examined. The article then focuses on rehabilitation. Attention is directed to particular suggestions for reform, leading to a postulation of new directions in treatment of the female offender.

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SNI case of the week: Initial concomitant use of gabapentin, clonidine, and prednisone may enhance suicidal ideation: A case report

Surgical Neurology International ◽

10.25259/sni_58_2020 ◽

2020 ◽

Vol 11 ◽

pp. 41

Author(s):

Ramsis F. Ghaly ◽

Ana Plesca ◽

Kenneth D. Candido ◽

Nebojsa Nick Knezevic

Keyword(s):

Suicide Risk ◽

Alcoholic Hepatitis ◽

Gunshot Wound ◽

Concomitant Administration ◽

Hepatic Disease ◽

Major Depressive ◽

The Past ◽

History Of ◽

Alcoholic Drinks ◽

First Time

Background: Suicide cases are the end product of a combination of biological, clinical, psychological, social, and cultural risk/protective factors, and attempts to remain unpredictable. Case Description: A 43-year-old male presented to the hospital with jaundiced skin/eyes of 7 days’ duration. He had a history of a major depressive disorder and chronic alcohol consumption (e.g., 3–5 alcoholic drinks/day for the past 15 years). Studies documented acute hepatic disease (e.g., biopsy-documented hepatocellular alcoholic hepatitis), accompanied by a cholestatic disease. The patient was discharged on clonidine, iron multivitamin, folic acid, gabapentin, and prednisone. Eight days postdischarge from the hospital, he committed suicide (e.g., self- inflicted gunshot wound to the head). Conclusion: Concomitant administration of gabapentin, prednisone, and clonidine, especially if used for the first time, may play a synergistic effect in increasing a patient’s suicide risk.

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Violent parasomnias and sleep forensics

10.1093/med/9780199682003.003.0052 ◽

2017 ◽

Author(s):

Michel A. Cramer Bornemann ◽

Mark R. Pressman

Keyword(s):

Genetic Predisposition ◽

Expert Testimony ◽

Scientific Evidence ◽

Criminal Court ◽

Court Cases ◽

Deep Sleep ◽

Criminal Cases ◽

Legal Requirements ◽

History Of ◽

Science And Research

Parasomnias are complex behaviors occurring out of or during sleep. Parasomnias are increasingly presented as proof of an automatism in criminal cases involving violence. The sleep forensics expert must have an up-to-date understanding of current sleep science and research, diagnostic and clinical techniques, and the legal requirements of expert testimony and scientific evidence. Sleepwalking and related disorders typically follow sudden, partial awakenings from deep sleep. Higher-level cognition is severely limited or absent, and complex behaviors often consist of “automatic” behaviors not initiated or guided by memory or planning. Sleepwalking and related disorders are noted to occur during deep sleep and often require a genetic predisposition or priming factors. Prior cases of sleepwalking violence find that the victim of sleepwalking violence—most often a family member—seeks out the sleepwalker. The history of sleepwalking includes reports of episodes and sometimes criminal court cases of murder, assault, and rape.

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The Forgotten Female Offender

Crime & Delinquency ◽

10.1177/001112877702300201 ◽

1977 ◽

Vol 23 (2) ◽

pp. 101-108 ◽

Cited By ~ 12

Author(s):

Ray R. Price

Keyword(s):

Criminal Justice ◽

Criminal Justice System ◽

Justice System ◽

Female Offender ◽

Negative Effects ◽

Female Crime ◽

New Directions ◽

Disparate Treatment ◽

History Of ◽

System Information

Until recently the female offender was generally overlooked by an overwhelmingly male-dominated criminal justice system. Information derived from an extensive search of the literature illustrates the dramatic increase of female crime; it further suggests the potential for modifying the sexist nature of the criminal justice system. Questions are raised about some popular misconceptions pertaining to the data. A review of the history of women's involvement as subjects of the criminal justice system in general, and correction in particular, reveals disparate treatment for men and women throughout that process. Both positive and negative effects of this orientation are examined. The article then focuses on rehabilitation. Attention is directed to particular suggestions for reform, leading to a postulation of new directions in treatment of the female offender.

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Mykola Vegesh, Stepan Vidnianskyi. Augustyn Voloshin is the «Father of the Carpatho- Ukrainian People». Kyiv: Parliamentary Publishing House, 2020. 469 p.

Scientific Papers of the Vinnytsia Mykhailo Kotsyiubynskyi State Pedagogical University Series History ◽

10.31652/2411-2143-2021-37-108-110 ◽

2021 ◽

pp. 108-110

Author(s):

Igor Mazylo ◽

Keyword(s):

Eastern Europe ◽

Publishing House ◽

Scientific Publication ◽

European Region ◽

Deep Sleep ◽

Central European ◽

Central Eastern Europe ◽

Central European Region ◽

History Of ◽

The Subject

The article analyzes the scientific publication «Avgustin Voloshin – «the father of the Carpathian Ukrainian people» by the authors of S. V. Vidnyansky and N. N. Vegesha, well-known specialists in Ukraine on the history of the countries of Central - Eastern Europe and such a Central European region as Transcarpathia. Therefore, they are perfectly familiar with the material and know the subject of the research. In their opinion, the process of national revival of Transcarpathian Ukrainians in the 30s is associated with the personality of A. Voloshin as an educational, socio-political and statesman of the 20-th century. The authors of the book noted that the figure of A. Voloshin belongs to the great people of Transcarpathia and equates him with the personality of O. Dukhnovich, who devoted his life to the struggle for the better fate of his people and called on his compatriots to «put an end to deep sleep». The authors of the study described A. Voloshin’s personality in a new complex way and characterized his activities.

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Epilepsy in the history of Europe in the 19th century

Neurology Bulletin ◽

10.17816/nb50128 ◽

2020 ◽

Vol VII (3) ◽

pp. a1-a20

Author(s):

N. M. Popov

Keyword(s):

19Th Century ◽

Coming Out ◽

Entire Body ◽

Deep Sleep ◽

Patient Falls ◽

General Weakness ◽

History Of ◽

History Of Europe ◽

The 19Th Century ◽

As If

Epilepsy, or epilepsy, belongs to the number of very common nervous diseases and without doubt, I have even seen seizures with which it manifests itself: a man, apparently completely healthy, suddenly cries out and, as if struck by some mysterious force, without consciousness falls to the ground; terrible convulsions engulf his entire body; foam near the mouth, not lightly stained with blood. This usually lasts not for a few minutes; then the patient falls into a deep sleep, coming out of which, he does not remember anything that happened, but only complains of general weakness and fatigue.

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Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

The Neurohospitalist ◽

10.1177/1941874416665744 ◽

2016 ◽

Vol 7 (1) ◽

pp. 9-14 ◽

Cited By ~ 10

Author(s):

Michael J. Erdman ◽

Heidi Riha ◽

Lauren Bode ◽

Jason J. Chang ◽

G. Morgan Jones

Keyword(s):

Acute Kidney Injury ◽

Hypertonic Saline ◽

Neurocritical Care ◽

Univariate Analysis ◽

Kidney Injury ◽

Concomitant Administration ◽

Medical Centers ◽

Institutional Review ◽

Academic Medical ◽

History Of

Background and Purpose: Continuous intravenous 3% hypertonic saline (HTS) infusions are commonly used for the management of cerebral edema following severe neurologic injuries. Despite widespread use, data regarding the incidence and predictors of nephrotoxicity are lacking. The purpose of this study was to describe the incidence and identify predictors of acute kidney injury (AKI) in neurocritical care patients administered continuous infusion HTS. Methods: This was an institutional review board–approved, multicenter, retrospective cohort study of patients receiving HTS infusions at 2 academic medical centers. A univariate analysis and multivariable logistic regression were used to identify predictors of AKI. Data regarding AKI were evaluated during treatment with HTS and up to 24 hours after discontinuation. Results: A total of 329 patients were included in our analysis, with 54 (16%) developing AKI. Those who developed AKI experienced significantly longer stays in the intensive care unit (14.8 vs 11.5 days; P = .006) and higher mortality (48.1% vs 21.9%; P < .001). We identified past medical history of chronic kidney disease (odds ratio [OR]: 9.7, 95% confidence interval [CI]: 1.9-50.6; P = .007), serum sodium greater than 155 mmol/L (OR: 4.1, 95% CI: 2.1-8.0; P < .001), concomitant administration of piperacillin/tazobactam (OR: 3.9, 95% CI: 1.7-9.3; P = .002), male gender (OR: 3.2, 95% CI: 1.5-6.6; P = .002), and African American race (OR: 2.6, 95% CI: 1.3-5.2; P = .007) as independent predictors of AKI. Conclusion: Acute kidney injury is relatively common in patients receiving continuous HTS and may significantly impact clinical outcomes.

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Use of phenytoin for treatment of tacrolimus toxicity with superimposed sepsis

BMJ Case Reports ◽

10.1136/bcr-2020-234839 ◽

2020 ◽

Vol 13 (7) ◽

pp. e234839 ◽

Cited By ~ 1

Author(s):

Aditi Sharma ◽

Krista A Wahby ◽

Mohammed Inany ◽

Sarah J Lee

Keyword(s):

Reference Range ◽

Enzyme System ◽

Kidney Injury ◽

Concomitant Administration ◽

Muscle Cramps ◽

Graft Versus Host ◽

History Of ◽

Tacrolimus Level ◽

Cyp 3A ◽

Successful Reduction

A 40-year-old woman with a history of chronic graft-versus-host-disease on immunosuppression with tacrolimus presented to the hospital with somnolence, confusion and muscle cramps over a few days. She was found to have hypertension, hyperglycaemia and acute kidney injury with an elevated blood tacrolimus level of greater than 120 ng/mL (reference range 5–15 ng/mL). Discontinuation of tacrolimus with concomitant administration of intravenous phenytoin led to the successful reduction of elevated tacrolimus concentrations and the resolution of her symptoms. Tacrolimus is metabolised by the cytochrome P (CYP) 450 3A enzyme system, and utilisation of CYP 3A inducers to accelerate its clearance may be used as a successful therapy to treat tacrolimus toxicity.

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