Infrared Responsive Choline Phosphate Lipids for Cancer Synergistic Therapy

1. Blowfly flight-muscle mitochondria respiring in the absence of phosphate acceptor (i.e. in state 4) take up greater amounts of K+, Na+, choline, phosphate and Cl-(but less NH4+) than non-respiring control mitochondria. 2. Uptake of cations is accompanied by an increase in the volume of the mitochondrial matrix, determined with the use of [14C]-sucrose and3H2O. The osmolarity of the salt solution taken up was approximately that of the suspending medium. 3. The [14C]sucrose-inaccessible space decreased with increasing osmolarity of potassium chloride in the suspending medium, confirming that the blowfly mitochondrion behaves as an osmometer. 4. Light-scattering studies showed that both respiratory substrate and a permeant anion such as phosphate or acetate are required for rapid and massive entry of K+, which occurs in an electrophoretic process rather than in exchange for H+. The increase in permeability to K+and other cations is probably the result of a large increase in the exposed area of inner membrane surface in these mitochondria, with no intrinsic increase in the permeability per unit area. 5. No increase in permeability to K+and other cations occurs during phosphorylation of ADP in state 3 respiration.

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A Thermoreversible Poly(Choline Phosphate) Based Universal Biomembrane Adhesive

Macromolecular Bioscience ◽

10.1002/mabi.201300425 ◽

2013 ◽

Vol 14 (3) ◽

pp. 334-339 ◽

Cited By ~ 10

Author(s):

Xifei Yu ◽

Xiaoqiang Yang ◽

Sonja Horte ◽

Jayachandran N. Kizhakkedathu ◽

Donald E. Brooks

Keyword(s):

Choline Phosphate

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Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ◽

10.1016/0005-2760(88)90219-6 ◽

1988 ◽

Vol 958 (3) ◽

pp. 343-351 ◽

Cited By ~ 33

Author(s):

Avinash Chander ◽

Aron B. Fisher

Keyword(s):

Fatty Acids ◽

Choline Phosphate ◽

Phosphatidylcholine Synthesis

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Promoting Effect of Choline-Phosphate Cytidylyltransferase Gene (pcyt-1) on Departure of Pinewood Nematode from Monochamus alternatus

Forests ◽

10.3390/f13010114 ◽

2022 ◽

Vol 13 (1) ◽

pp. 114

Author(s):

Yang Wang ◽

Mingxia Jin ◽

Lichao Wang ◽

Ailin Yu ◽

Guai Xie ◽

...

Keyword(s):

Gene Expression ◽

Bursaphelenchus Xylophilus ◽

Pinewood Nematode ◽

Monochamus Alternatus ◽

Internal Factor ◽

Promoting Effect ◽

Lipid Degradation ◽

Sufficient Energy ◽

Lipid Granules ◽

Choline Phosphate

In order to study the key gene in internal causes of pinewood nematode (PWN), Bursaphelenchus xylophilus, a departure from its vector beetle, Monochamus alternatus, we collected PWNs extracted from newly emerged M. alternatus and beetles 7 days after emergence. The total RNAs of the two groups of PWNs were extracted, transcriptomes sequencing was performed, and gene expression differences between the two groups of PWN were analyzed. It was found that the expression of the choline-phosphate cytidylyltransferase gene (pcyt-1) was markedly up-regulated. After inhibition of pcyt-1 expression by RNA interference, the rate of lipid degradation in PWN decreased significantly, and the motility of PWN also decreased significantly. The analysis identified that phosphatidylcholine could promote the emulsification and degradation of neutral lipid granules in PWN, which provides sufficient energy for PWN departure from M. alternatus. The up-regulation of the gene pcyt-1 is an important internal factor for PWN departure from its vector.

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Synthesis of a conductive polymer thin film having a choline phosphate side group and its bioadhesive properties

Chemical Communications ◽

10.1039/c9cc09949b ◽

2020 ◽

Vol 56 (18) ◽

pp. 2691-2694 ◽

Cited By ~ 3

Author(s):

Masaru Mukai ◽

Chao-Hung Cheng ◽

Wei Ma ◽

Mi Chin ◽

Chia-Hsin Lin ◽

...

Keyword(s):

Thin Film ◽

Cell Adhesion ◽

Bovine Serum Albumin ◽

Conductive Polymer ◽

Fibroblast Cell ◽

Albumin Binding ◽

Side Group ◽

Polymer Thin Film ◽

Choline Phosphate ◽

Bovine Serum Albumin Binding

A conductive polymer thin film having choline phosphate as the side group was prepared. The polymer thin film can prevent bovine serum albumin binding while present nice fibroblast cell adhesion.

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Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

Biomaterials Science ◽

10.1039/c9bm00051h ◽

2019 ◽

Vol 7 (4) ◽

pp. 1335-1344 ◽

Cited By ~ 2

Author(s):

Xiaoqiu Li ◽

Yangyang Zhao ◽

Wei Jiang ◽

Shuya Li ◽

Meixiao Zhan ◽

...

Keyword(s):

Choline Phosphate

Vorinostat-sensitized radiotherapy aggravates hypoxia and then activates AQ4N to kill radiotherapy-tolerating hypoxic cells and achieve the synergism of cascaded chemo-radiotherapy.

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