ChemInform Abstract: INVESTIGATIONS IN THE FIELD OF N-ARYL-BETA-AMINO ACIDS PART 3, HYDRAZINES OF N-ARYLSULFONYL-BETA-ALANINE

1973 ◽  
Vol 4 (44) ◽  
pp. no-no
Author(s):  
V. T. BRAICHENKO ◽  
Z. F. SOLOMKO ◽  
M. S. MALINOVSKII ◽  
R. F. RED'KO
Keyword(s):  
Amino Acids ◽  
Beta Alanine

Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation*

1964 ◽  
Vol 11 (01) ◽  
pp. 064-074 ◽  
Author(s):  
Robert H Wagner ◽  
William D McLester ◽  
Marion Smith ◽  
K. M Brinkhous
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Factor Viii ◽  
Plasma Protein ◽  
Acid Precipitation ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Specific Procedure ◽  
Beta Alanine ◽  
Antihemophilic Factor

Summary1. The use of several amino acids, glycine, alpha-aminobutyric acid, alanine, beta-alanine, and gamma-aminobutyric acid, as plasma protein precipitants is described.2. A specific procedure is detailed for the preparation of canine antihemophilic factor (AHF, Factor VIII) in which glycine, beta-alanine, and gammaaminobutyric acid serve as the protein precipitants.3. Preliminary results are reported for the precipitation of bovine and human AHF with amino acids.

scholarly journals Ingesting a pre-workout supplement containing caffeine, B-vitamins, amino acids, creatine, and beta-alanine before exercise delays fatigue while improving reaction time and muscular endurance

2012 ◽  
Vol 9 (1) ◽  
pp. 28 ◽  
Author(s):  
Brandon D Spradley ◽  
Kristy R Crowley ◽  
Chih-Yin Tai ◽  
Kristina L Kendall ◽  
David H Fukuda ◽  
...  
Keyword(s):  
Amino Acids ◽  
Reaction Time ◽  
B Vitamins ◽  
Muscular Endurance ◽  
Beta Alanine

scholarly journals Short Report: Using Targeted Urine Metabolomics to Distinguish Between Manganese Exposed and Unexposed Workers in a Small Occupational Cohort

2021 ◽  
Vol 9 ◽  
Author(s):  
Kayla A. Carter ◽  
Christopher D. Simpson ◽  
Daniel Raftery ◽  
Marissa G. Baker
Keyword(s):  
Amino Acids ◽  
Pathway Analysis ◽  
Short Report ◽  
Targeted Metabolomics ◽  
Metabolomics Data ◽  
Mn Toxicity ◽  
Spot Urine ◽  
Beta Alanine ◽  
Neurological Outcomes ◽  
Exposed Workers

Objectives: Despite the widespread use of manganese (Mn) in industrial settings and its association with adverse neurological outcomes, a validated and reliable biomarker for Mn exposure is still elusive. Here, we utilize targeted metabolomics to investigate metabolic differences between Mn-exposed and -unexposed workers, which could inform a putative biomarker for Mn and lead to increased understanding of Mn toxicity.Methods: End of shift spot urine samples collected from Mn exposed (n = 17) and unexposed (n = 15) workers underwent a targeted assay of 362 metabolites using LC-MS/MS; 224 were quantified and retained for analysis. Differences in metabolite abundances between exposed and unexposed workers were tested with a Benjamini-Hochberg adjusted Wilcoxon Rank-Sum test. We explored perturbed pathways related to exposure using a pathway analysis.Results: Seven metabolites were significantly differentially abundant between exposed and unexposed workers (FDR ≤ 0.1), including n-isobutyrylglycine, cholic acid, anserine, beta-alanine, methionine, n-isovalerylglycine, and threonine. Three pathways were significantly perturbed in exposed workers and had an impact score >0.5: beta-alanine metabolism, histidine metabolism, and glycine, serine, and threonine metabolism.Conclusion: This is one of few studies utilizing targeted metabolomics to explore differences between Mn-exposed and -unexposed workers. Metabolite and pathway analysis showed amino acid metabolism was perturbed in these Mn-exposed workers. Amino acids have also been shown to be perturbed in other occupational cohorts exposed to Mn. Additional research is needed to characterize the biological importance of amino acids in the Mn exposure-disease continuum, and to determine how to appropriately utilize and interpret metabolomics data collected from occupational cohorts.

scholarly journals Dynamics of Bacterial and Fungal Communities and Metabolites During Aerobic Exposure in Whole-Plant Corn Silages With Two Different Moisture Levels

2021 ◽  
Vol 12 ◽  
Author(s):  
Chunsheng Bai ◽  
Chao Wang ◽  
Lin Sun ◽  
Haiwen Xu ◽  
Yun Jiang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Lactic Acid ◽  
Moisture Content ◽  
Essential Amino Acids ◽  
Fungal Communities ◽  
High Moisture Content ◽  
High Moisture ◽  
Beta Alanine ◽  
Aerobic Stability ◽  
Whole Plant

The study was aimed to investigate the effect of moisture content on microbial communities, metabolites, fermentation quality, and aerobic stability during aerobic exposure in whole-plant corn silages preserved long time to improve the quality and aerobic stability of the silage during feed-out. Corn plants with two different moisture levels (high-moisture content, 680 g/kg; low-moisture content, 620 g/kg) were harvested at one-third and two-thirds milk-line stages, respectively, ensiled in laboratory-scale silos, and then sampled at 350 day after ensiling and at 2 and 5 day after opening to investigate bacterial and fungal communities, metabolites, and aerobic stability. High-moisture content increased aerobic stability and pH and decreased lactic acid and microbial counts in silages (P < 0.05). During aerobic exposure, the low-moisture silages had higher pH and lactic acid bacterial count and lower lactic acid than the high-moisture silages (P < 0.05); Acinetobacter sp. was the most main bacterial species in the silages; Candida glabrata and unclassified Candida had an increasing abundance and negatively correlation with aerobic stability of high-moisture silages (P < 0.05), while C. glabrata, Candida xylopsoci, unclassified Saccharomycetaceae, and unclassified Saccharomycetales negative correlated with aerobic stability of low-moisture silages (P < 0.05) with a rising Saccharomycetaceae; the silages had a reducing concentration of total metabolites (P < 0.05). Moreover, the high-moisture silages contained greater total metabolites, saturated fatty acids (palmitic and stearic acid), essential fatty acids (linoleic acid), essential amino acids (phenylalanine), and non-essential amino acids (alanine, beta-alanine, and asparagine) than the low-moisture silages at 5 day of opening (P < 0.05). Thus, the high-moisture content improved the aerobic stability. Acinetobacter sp. and Candida sp. dominated the bacterial and fungal communities, respectively; Candida sp. resulted in the aerobic deterioration in high-moisture silages, while the combined activities of Candida sp. and Saccharomycetaceae sp. caused the aerobic deterioration in low-moisture silages. The greater aerobic stability contributed to preserve the palmitic acid, stearic acid, linoleic acid, phenylalanine, alanine, beta-alanine, and asparagine during aerobic exposure.

Effect of amino acid intake on brush-border membrane uptake of sulfur amino acids

1986 ◽  
Vol 251 (1) ◽  
pp. F125-F131
Author(s):  
R. W. Chesney ◽  
N. Gusowski ◽  
M. Padilla ◽  
S. Lippincott
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Brush Border ◽  
Time Course ◽  
Brush Border Membrane ◽  
Sulfur Amino Acids ◽  
Beta Alanine ◽  
Renal Brush Border Membrane ◽  
Amino Acid Intake ◽  
Renal Brush Border

Alterations in the intake of sulfur amino acids (SAA) changes the rat renal brush-border membrane uptake of the beta-amino acid, taurine. A low-SAA diet enhances and a high-taurine diet reduces uptake (Chesney et al., Kidney Int. 24: 588-594, 1983). Neither the low-SAA diet nor the high-taurine diet alters the time course or concentration-dependent accumulation of the sulfur amino acids methionine and cystine or of inorganic sulfate. By contrast the uptake of beta-alanine, another beta-amino acid that competes with taurine, is greater in animals on the low-SAA diet. The high-taurine diet does not change beta-alanine uptake. The plasma levels of taurine are altered by dietary change, but not the values for methionine and cystine. This study indicates that renal adaptation is expressed for beta-alanine, a nonsulfur-containing beta-amino acid. By contrast, methionine, cystine, and sulfate, which participate in a variety of synthetic and conjugative processes, are not conserved by the renal brush-border surface following ingestion of either a low-methionine and -cystine diet or high-taurine diet.

Renal secretion of amino acids in ophidian reptiles

1986 ◽  
Vol 250 (4) ◽  
pp. R712-R720 ◽  
Author(s):  
S. Benyajati ◽  
W. H. Dantzler
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Tubular Secretion ◽  
Cysteic Acid ◽  
Thamnophis Sirtalis ◽  
Renal Secretion ◽  
Renal Tubular Secretion ◽  
Beta Alanine ◽  
Renal Tubular ◽  
Filtered Load

Net renal tubular secretion of endogenous beta-amino acids (taurine, beta-alanine, beta-aminoisobutyric acid) and their endogenous analogue (L-cysteic acid) was revealed in the olive sea snake, Aipysurus laevis, and in the garter snake, Thamnophis sirtalis, by renal clearance methods. The net secretory rates ranged from 16 to 795 nmol X kg-1 X h-1, with taurine being secreted at the highest rates. These rates of secretion are comparable to those observed in marine fish, the only other group of vertebrates exhibiting renal tubular secretion of L-amino acids under physiological conditions. However, only some snakes (8-58%) demonstrated net tubular secretion; the others (0-58%) showed net tubular reabsorption of these amino acids. Net tubular secretion was consistently observed whenever the filtered load of the amino acid was low, and net reabsorption was apparent whenever the filtered load was high; the two variables being significantly correlated. An analysis of the net amino acid transport rates, both secretory and reabsorptive, as a function of the filtered load suggests that in snakes the beta-amino acids are reabsorbed and secreted at discrete tubular sites, with the secretory sites located beyond the major reabsorptive sites. Taurine, beta-alanine, and L-cysteic acid appear to share a common transport system in the snake renal tubule cells.

Modification of Polyfluoro-Containing 3-(Ethoxycarbonyl)flavones by Biogenic Amines and Amino Acids

2018 ◽  
Vol 15 (5) ◽  
pp. 707-714 ◽  
Author(s):  
Konstantin V. Shcherbakov ◽  
Yanina V. Burgart ◽  
Victor I. Saloutin ◽  
Oleg N. Chupakhin
Keyword(s):  
Amino Acids ◽  
Biogenic Amines ◽  
Nucleophilic Aromatic Substitution ◽  
Gamma Aminobutyric Acid ◽  
Aromatic Substitution ◽  
Substitution Product ◽  
Reaction Conditions ◽  
Pyrone Ring ◽  
Beta Alanine ◽  
Ir Spectroscopic

Aim and Objective: The objective of our work was to study the peculiarities of transformations of fluorine-containing flavone-3-carboxylates with N-nucleophiles, including biogenic amines and amino acids. Materials and Methods: 6,7,8-Trifluoro and 5,6,7,8-tetrafluoroflavone-3-carboxylates were involved in interactions with a number of N-nucleophiles, such as pyrrolidine, morpholine, proline, arginine, gammaaminobutyric acid, beta-alanine, histamine, dopamine and amantadine under different reaction conditions. All synthesized compounds were characterized by NMR 1H, 19F, (NMR 13C for some compounds) and IR spectroscopic data, and elemental analysis. Results: 3-(Ethoxycarbonyl)polyfluoroflavones react with morpholine, pyrrolidine and L-proline to form 7- monosubstituted flavone-3-carboxylates. For the reactions of tetrafluoroflavone with pyrrolidine and morpholine, the formation of 5,7-disubstituted products is also possible. Interaction with gamma-aminobutyric acid leads to the 4-{[3-ethoxy-2-(2-hydroxypolyfluorobenzoyl)-3-oxo-1-phenylprop-1-enyl]amino}butanoic acids as a result of the pyrone ring opening. In reactions with dopamine, histamine, L-arginine and β-alanine, polyfluoroflavone-3-carboxylates underwent a chromone-coumarin rearrangement. 3-(Ethoxycarbonyl)tetrafluoroflavone forms with amantadine the nucleophilic aromatic substitution product, while trifluoro-substituted analog gives the chromone-coumarin rearrangement product. Conclusion: This work showed possibilities of chemical modification of polyfluorinated flavones in the reactions with amines depending on the structure of the nucleophilic reagent. Synthesized compounds are of interest for biological testing.

Na+-independent transport of bipolar and cationic amino acids across the luminal membrane of the small intestine

1997 ◽  
Vol 272 (4) ◽  
pp. R1060-R1068 ◽  
Author(s):  
B. G. Munck ◽  
L. K. Munck
Keyword(s):  
Amino Acids ◽  
Brush Border ◽  
Brush Border Membrane ◽  
Short Circuit ◽  
Present System ◽  
Rabbit Ileum ◽  
Beta Alanine ◽  
Brown Adipose ◽  
Cationic Amino Acids

The role of sodium in transport of bipolar and cationic amino acids and their interactions were examined in vitro by measuring unidirectional influx across the brush-border membrane of intact rat jejunal and rabbit ileal epithelia. The chloride-dependent and beta-alanine inhibitable B(0,+) present in rabbit ileum was blocked by combining inhibition by beta-alanine with Na(+)- or Cl(-)-free conditions. Under these conditions, lysine influx across the brush-border membrane is Na+ independent. All Na+-independent influx of cationic and bipolar amino acids is by a system b(0,+) equivalent in the brush-border membrane of both species, where a system y+ is not present. System b(0,+) is shown to be a potent exchanger of intracellular leucine for extracellular lysine and of intracellular lysine for extracellular leucine. The model used to explain leucine stimulation of mucosa to serosa lysine transport can explain Na+ dependence of net lysine absorption. On the assumption that b(0,+) in situ, like the transporter induced by retroperitoneal brown adipose tissue in Xenopus laevi oocytes, acts as an obligatory exchanger, this model can also explain the effects of lysine on short-circuit current and net transport of sodium and the effect on transport capacity by preincubation at Na+-free conditions.

AMINO ACID PATTERN IN THE BLOOD OF RATS WITH DIETARY HEPATIC NECROSIS

1960 ◽  
Vol 38 (1) ◽  
pp. 365-373
Author(s):  
L. S. Valberg ◽  
J. M. R. Beveridge
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Glutamic Acid ◽  
Reduced Glutathione ◽  
Liver Lesion ◽  
Hepatic Necrosis ◽  
Chromatographic Study ◽  
Oxidized Glutathione ◽  
Liver Necrosis ◽  
Beta Alanine

A paper chromatographic study of the amino acids and peptides in the blood of rats with dietary liver necrosis has been made.The relative levels of alanine, methionine, tyrosine, glutamic acid, threonine, citrulline, glutamine, oxidized glutathione, and gamma aminoisobutyric acid were increased. The level of reduced glutathione was slightly reduced and levels of valine, taurine, and proline remained unchanged. Beta-alanine, which could not be detected in the blood of normal rats, was found in the case of those with acute liver damage.Although arginine was present in the blood of normal animals and in those on a necrogenic diet prior to the development of the liver lesion, it was not detectable in those animals with acute hepatic necrosis. The possible implications of this finding have been discussed.

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