ChemInform Abstract: ′On-water′ Organic Synthesis: A Green, Highly Efficient, Low Cost and Reusable Catalyst System for Biaryl Synthesis under Aerobic Conditions at Room Temperature.

ChemInform ◽  
2015 ◽  
Vol 46 (43) ◽  
pp. no-no
Author(s):  
Bishwajit Saikia ◽  
Preeti Rekha Boruah ◽  
Abdul Aziz Ali ◽  
Diganta Sarma
Keyword(s):  
Organic Synthesis ◽  
Room Temperature ◽  
Low Cost ◽  
Catalyst System ◽  
Reusable Catalyst ◽  
Aerobic Conditions ◽  
Highly Efficient ◽  
Biaryl Synthesis

‘On-water’ organic synthesis: a green, highly efficient, low cost and reusable catalyst system for biaryl synthesis under aerobic conditions at room temperature

RSC Advances ◽  
2015 ◽  
Vol 5 (63) ◽  
pp. 50655-50659 ◽  
Author(s):  
Bishwajit Saikia ◽  
Preeti Rekha Boruah ◽  
Abdul Aziz Ali ◽  
Diganta Sarma
Keyword(s):  
Organic Synthesis ◽  
Room Temperature ◽  
Low Cost ◽  
Suzuki Reaction ◽  
Catalyst System ◽  
Reusable Catalyst ◽  
Wide Range ◽  
Biaryl Synthesis ◽  
Phenylboronic Acids ◽  
Operational Simplicity

The PdCl2/sucrose/K2CO3/H2O system showed the superb catalytic activity towards the Suzuki reaction of a wide range of aryl/heteroaryl halides with diverse phenylboronic acids at room temperature with operational simplicity and shorter reaction time.

Pd(OAc)2 and (DHQD)2PHAL as a simple, efficient and recyclable/reusable catalyst system for Suzuki–Miyaura cross-coupling reactions in H2O at room temperature

2015 ◽  
Vol 39 (4) ◽  
pp. 2440-2443 ◽  
Author(s):  
Bishwajit Saikia ◽  
Abdul Aziz Ali ◽  
Preeti Rekha Boruah ◽  
Diganta Sarma ◽  
Nabin Chandra Barua
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Catalyst System ◽  
Reusable Catalyst ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Cross Coupling Reaction

Suzuki–Miyaura cross-coupling reaction catalyzed by Pd(OAc)2–(DHQD)2PHAL is a very simple, mild, efficient and recyclable/reusable protocol for the synthesis of biaryls/heterobiaryls in neat H2O at room temperature.

scholarly journals Multicomponent Synthesis of 2-(2,4-Diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonic Acids in DMSO

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6839
Author(s):  
Yuliya E. Ryzhkova ◽  
Michail N. Elinson ◽  
Oleg I. Maslov ◽  
Artem N. Fakhrutdinov
Keyword(s):  
Reaction Mechanism ◽  
Organic Synthesis ◽  
Multicomponent Reactions ◽  
Room Temperature ◽  
Low Cost ◽  
2D Nmr ◽  
Biologically Active ◽  
Multicomponent Synthesis ◽  
2D Nmr Spectroscopy ◽  
Low Toxicity

Dimethyl sulfoxide is a widely used solvent in organic synthesis and in the pharmaceutical industry because of its low cost, stability, and low toxicity. Multicomponent reactions are an advanced approach that has become an efficient, economical, and eco-friendly substitute for the conventional sequential multi-step synthesis of various biologically active compounds. This approach was adopted for the synthesis of previously unknown 2-(2,4-diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonic acids via transformation of salicylaldehydes, malononitrile dimer, and malonic acid. It was shown that the use of DMSO at room temperature makes it possible to synthesize previously unavailable compounds. The investigation of the reaction mechanism using 1H-NMR monitoring made it possible to confirm the proposed mechanism of the transformation. The structure of synthesized 5H-chromeno[2,3-b]pyridines was confirmed by 2D-NMR spectroscopy.

Highly Efficient Michael Reactions of Nitroolefins by Grinding Means

2019 ◽  
Vol 16 (3) ◽  
pp. 449-457 ◽  
Author(s):  
Dong-Xiao Cui ◽  
Yue-Dan Li ◽  
Jun-Chao Zhu ◽  
Yan-Yan Jia ◽  
Ai-Dong Wen ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Room Temperature ◽  
Michael Reaction ◽  
Building Blocks ◽  
Solvent Free ◽  
Michael Additions ◽  
Highly Efficient ◽  
Michael Reactions ◽  
Michael Adducts ◽  
Solvent Free Conditions

Aim and Objective: The direct β-functionalization of trans-β-nitroolefins by Michael reaction is regarded as an efficient way to provide precursors for β-functional amines. However, Michael additions by grinding means with solvent-free conditons are rarely reported. We have developed facile access to β-functional nitroalkanes by grinding means under solvent-free conditions. Materials and Methods: From commercially available materials including ethyl 2-nitroacetate, alkyl 2-cyanoacetates and malononitrile, the grinding reactions between these above-mentioned activated methylenecompounds and various trans-β-nitroolefins were performed at room temperature and solvent-free conditions. Results: A highly efficient direct Michael reaction of nitroolefins by simple grinding means has been developed. Various trans-nitrostyrenes were easily converted into corresponding β-functional nitroalkanes in excellent yields within 5~10 min (up to 36 examples). Conclusion: Herein, we have developed a simple and efficient way to β-functional nitroalkanes through Michael reactions by grinding means. The grinding Michael reaction is fast, clean and stable and these Michael adducts could be easily converted into the other amino compounds served as building blocks in organic synthesis.

Pd(OAc)2 in WERSA: a novel green catalytic system for Suzuki–Miyaura cross-coupling reactions at room temperature

2015 ◽  
Vol 51 (57) ◽  
pp. 11489-11492 ◽  
Author(s):  
Preeti Rekha Boruah ◽  
Abdul Aziz Ali ◽  
Mitali Chetia ◽  
Bishwajit Saikia ◽  
Diganta Sarma
Keyword(s):  
Catalytic System ◽  
Room Temperature ◽  
Cross Coupling ◽  
Catalyst System ◽  
Reusable Catalyst ◽  
Organic Media ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Pd(OAc)2–WERSA as a novel, efficient and recyclable/reusable catalyst system for Suzuki–Miyaura cross-coupling reactions at room temperature. This is a ligand/base/promoter/additive/organic media free protocol.

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