scholarly journals Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth

ChemMedChem ◽  
2016 ◽  
Vol 11 (19) ◽  
pp. 2205-2215 ◽  
Author(s):  
Janish Desai ◽  
Yang Wang ◽  
Ke Wang ◽  
Satish R. Malwal ◽  
Eric Oldfield
Keyword(s):  
Cell Growth ◽  
Bacterial Cell ◽  
Isoprenoid Biosynthesis ◽  
Biosynthesis Inhibitors

Synthesis and preliminary anticancer evaluation of new triazole bisphosphonate-based isoprenoid biosynthesis inhibitors

2021 ◽  
Vol 214 ◽  
pp. 113241
Author(s):  
Thibaut Legigan ◽  
Evelyne Migianu-Griffoni ◽  
Mohamed Abdenour Redouane ◽  
Aurélie Descamps ◽  
Julia Deschamp ◽  
...  
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Biosynthesis Inhibitors

scholarly journals Bacterial Cellulose as a Substrate for Microbial Cell Culture

2014 ◽  
Vol 80 (6) ◽  
pp. 1926-1932 ◽  
Author(s):  
Na Yin ◽  
Thiago M. A. Santos ◽  
George K. Auer ◽  
John A. Crooks ◽  
Piercen M. Oliver ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cell Growth ◽  
Physicochemical Properties ◽  
Stationary Phase ◽  
Bacterial Cellulose ◽  
Growth Rates ◽  
Bacterial Cell ◽  
Acetobacter Xylinum ◽  
Primary Factor ◽  
Nutrient Diffusion

ABSTRACTBacterial cellulose (BC) has a range of structural and physicochemical properties that make it a particularly useful material for the culture of bacteria. We studied the growth of 14 genera of bacteria on BC substrates produced byAcetobacter xylinumand compared the results to growth on the commercially available biopolymers agar, gellan, and xanthan. We demonstrate that BC produces rates of bacterial cell growth that typically exceed those on the commercial biopolymers and yields cultures with higher titers of cells at stationary phase. The morphology of the cells did not change during growth on BC. The rates of nutrient diffusion in BC being higher than those in other biopolymers is likely a primary factor that leads to higher growth rates. Collectively, our results suggest that the use of BC may open new avenues in microbiology by facilitating bacterial cell culture and isolation.

scholarly journals The Ethanologenic Bacterium Zymomonas mobilis Divides Asymmetrically and Exhibits Heterogeneity in DNA Content

2021 ◽  
Vol 87 (6) ◽  
Author(s):  
Katsuya Fuchino ◽  
Helena Chan ◽  
Ling Chin Hwang ◽  
Per Bruheim
Keyword(s):  
Cell Growth ◽  
Single Cell ◽  
Cell Size ◽  
Dna Content ◽  
Bacterial Cell ◽  
Zymomonas Mobilis ◽  
Biofuel Production ◽  
Public Attention ◽  
Content Type ◽  
Cell Organization

ABSTRACT The alphaproteobacterium Zymomonas mobilis exhibits extreme ethanologenic physiology, making this species a promising biofuel producer. Numerous studies have investigated its biology relevant to industrial applications and mostly at the population level. However, the organization of single cells in this industrially important polyploid species has been largely uncharacterized. In the present study, we characterized basic cellular behavior of Z. mobilis strain Zm6 under anaerobic conditions at the single-cell level. We observed that growing Z. mobilis cells often divided at a nonmidcell position, which contributed to variant cell size at birth. However, the cell size variance was regulated by a modulation of cell cycle span, mediated by a correlation of bacterial tubulin homologue FtsZ ring accumulation with cell growth. The Z. mobilis culture also exhibited heterogeneous cellular DNA content among individual cells, which might have been caused by asynchronous replication of chromosome that was not coordinated with cell growth. Furthermore, slightly angled divisions might have resulted in temporary curvatures of attached Z. mobilis cells. Overall, the present study uncovers a novel bacterial cell organization in Z. mobilis. IMPORTANCE With increasing environmental concerns about the use of fossil fuels, development of a sustainable biofuel production platform has been attracting significant public attention. Ethanologenic Z. mobilis species are endowed with an efficient ethanol fermentation capacity that surpasses, in several respects, that of baker’s yeast (Saccharomyces cerevisiae), the most-used microorganism for ethanol production. For development of a Z. mobilis culture-based biorefinery, an investigation of its uncharacterized cell biology is important, because bacterial cellular organization and metabolism are closely associated with each other in a single cell compartment. In addition, the current work demonstrates that the polyploid bacterium Z. mobilis exhibits a distinctive mode of bacterial cell organization, likely reflecting its unique metabolism that does not prioritize incorporation of nutrients for cell growth. Thus, another significant result of this work is to advance our general understanding in the diversity of bacterial cell architecture.

Characterization of Polysaccharide Production of Haemophilus influenzae Type b and Its Relationship to Bacterial Cell Growth

2003 ◽  
Vol 110 (2) ◽  
pp. 91-100 ◽  
Author(s):  
Mickie Takagi ◽  
Joaquin Cabrera-Crespo ◽  
Júlia Baruque-Ramos ◽  
Teresa Cristina Zangirolami ◽  
Isaias Raw ◽  
...  
Keyword(s):  
Cell Growth ◽  
Haemophilus Influenzae ◽  
Bacterial Cell ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Polysaccharide Production

scholarly journals Bacterial cell growth is arrested by violet and blue, but not yellow light excitation during fluorescence microscopy

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Nina El Najjar ◽  
Muriel C. F. van Teeseling ◽  
Benjamin Mayer ◽  
Silke Hermann ◽  
Martin Thanbichler ◽  
...  
Keyword(s):  
Cell Growth ◽  
Fluorescence Microscopy ◽  
Bacterial Cell ◽  
Yellow Light ◽  
Light Excitation

Susceptibility ofEscherichia coliO157 to chitosan-arginine in beef liquid purge is affected by bacterial cell growth phase

2013 ◽  
Vol 49 (2) ◽  
pp. 515-520 ◽  
Author(s):  
Rabya A. Lahmer ◽  
David L. Jones ◽  
Stacy Townsend ◽  
Shenda Baker ◽  
Arwel Prysor Williams
Keyword(s):  
Cell Growth ◽  
Growth Phase ◽  
Bacterial Cell
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