The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma

Aim A study was carried out to determine whether local recurrence after quadrantectomy, axillary dissection and radiotherapy (QUART) affects the oncologic prognosis of patients with early infiltrating breast carcinoma. Methods A total of 149 patients were submitted to QUART between 1981 and 1990 and followed by an average period of 120.9 months (range, 16–213). Local recurrence was not observed in 132 cases (group 1) but was detected in 17 patients (group 2). Results In group 1, 39 cases (29.5%) presented distant metastases and 34 (25.8%) evolved to death. In group 2, 10 (51.8%) distant metastases and 9 deaths (52.9%) were verified. The survival curves estimated by the Kaplan-Meier method and analyzed by the logrank test were statistically different for distant metastases-free survival (P = 0.03) and for overall survival (P = 0.01). The relative risk in patients with post-QUART local recurrence for distant metastases was 2.09 and for death 2.34. Conclusions It was concluded that post-QUART local recurrences are a poor prognostic factor in patients with early infiltrating breast carcinoma.

Download Full-text

Intratumoral Expression Level of Epidermal Growth Factor Receptor and Cytokeratin 5/6 Is Significantly Associated With Nodal and Distant Metastases in Patients With Basal-like Triple-Negative Breast Carcinoma

American Journal of Clinical Pathology ◽

10.1309/ajcprmd3aruo5wpn ◽

2010 ◽

Vol 134 (5) ◽

pp. 782-787 ◽

Cited By ~ 32

Author(s):

Lisa M. Sutton ◽

Jeong S. Han ◽

Kyle H. Molberg ◽

Venetia R. Sarode ◽

Dengfeng Cao ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Breast Carcinoma ◽

Epidermal Growth Factor ◽

Triple Negative ◽

Growth Factor Receptor ◽

Distant Metastases ◽

Triple Negative Breast Carcinoma ◽

Cytokeratin 5 ◽

Epidermal Growth

Download Full-text

Secretory Carcinoma in a 79- Year-Old Woman: An Exceptionally Rare Type of Breast Carcinoma

Rare Tumors ◽

10.4081/rt.2016.6650 ◽

2016 ◽

Vol 8 (4) ◽

pp. 188-190 ◽

Cited By ~ 2

Author(s):

Nelson Montalvo ◽

Veronica Posso ◽

Ligia Redrobán

Keyword(s):

Breast Carcinoma ◽

Distant Metastases ◽

The Elderly ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Secretory Carcinoma ◽

Rare Type ◽

Favorable Prognosis ◽

Palpable Breast ◽

Disease Free

Secretory breast carcinoma is an exceptionally rare mammary gland neoplasia described mainly in adult females and children of both sexes, and very rarely in the elderly. It has particular histopathological and immunohistochemical features and a favorable prognosis. We report the case of a 79-year-old Hispanic woman with a palpable breast mass. Currently, the patient is disease free after a followup period of 6 years without local recurrence or axillary lymph-nodes nor distant metastases.

Download Full-text

Influence of mutagenic versus non-mutagenic pre-operative chemotherapy on the immune infiltration of breast cancer

10.1101/455055 ◽

2018 ◽

Author(s):

Anna-Mária Tőkés ◽

Orsolya Rusz ◽

Gábor Cserni ◽

Erika Tóth ◽

Gábor Rubovszky ◽

...

Keyword(s):

Breast Carcinoma ◽

Tumor Infiltrating Lymphocytes ◽

Distant Metastases ◽

Chemotherapeutic Agents ◽

Hazard Ratio ◽

Stromal Tumor ◽

Survival Analyses ◽

The Difference ◽

Pre Treatment ◽

Infiltrating Lymphocytes

AbstractBackgroundChemotherapeutic agents are often mutagenic. Induction of mutation associated neo-epitopes is one of the mechanisms by which chemotherapy is thought to increase the number of tumor-infiltrating lymphocytes, but the clinical relevance of this triggered immune response is not known.We decided to investigate, whether treatment with various chemotherapeutic agents with significantly different mutagenic capacity induce a significantly different number of stromal tumor-infiltrating lymphocytes (StrTIL) in the clinical setting.Methods112 breast carcinoma cases treated with pre-operative chemotherapy were selected for the study. According to chemotherapy regimen 28/112 patients received platinum-based, 42/112 cyclophosphamide-based and 42/112 anthracycline-based chemotherapy. The percentage of stromal tumor-infiltrating lymphocytes (StrTIL) was evaluated on hematoxylineosin stained slides of pre-treatment core biopsy (pre-StrTIL) and post-treatment surgical tumor samples (post-StrTIL), according to the most recent recommendation of International TILs Working Group. In survival analyses, TIL changes (ΔStrTIL) were calculated from the difference between post-StrTIL and pre-StrTIL.ResultsOf the 112 cases, 58.0% (n=65) were hormone receptor (HR) positive and 42.0% (n=47) were HR negative. There was a trend of higher post-StrTIL compared to pre-StrTIL (median 6.25% vs. 3.00%; p<0.001). When analyzing the pre-StrTIL and post-StrTIL among the three treatment groups, we experienced significant StrTIL increase independently of the treatment applied. Based on the results of survival analyses both post-StrTIL and ΔStrTIL was found to be independent prognostic factor in HR negative cases. Each 1% increase in post-StrTIL reduced the hazard of distant metastases development by 2.6% (hazard ratio: 0.974; CI: 0.948-1.000; p=0.05) and for each 1% ΔStrTIL increment, the risk of distant metastases was reduced by 4.3% (hazard ratio: 0.957; CI: 0.932-0.983; p=0.001). The prognostic role of StrTIL in HR positive cases could not be proven.ConclusionsStrTIL expression might be stimulated by highly (platinum), moderately (cyclophosphamide) and marginally (taxane, anthracycline) mutagenic chemotherapeutic agents. Increase in StrTIL in residual cancer compared to pre-treatment tumor tissue is associated with improved distant metastasis-free survival in cases with HR negative breast carcinoma.

Download Full-text

Secretory breast carcinoma in a female adult with liver metastsis: a case report and literature review

Diagnostic Pathology ◽

10.1186/s13000-021-01156-6 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Jing Lian ◽

Li-Xia Wang ◽

Jiang-hong Guo ◽

Peng Bu ◽

Yan-feng Xi ◽

...

Keyword(s):

Liver Metastasis ◽

Breast Carcinoma ◽

Poor Prognosis ◽

Hormone Receptors ◽

Fatal Outcome ◽

Radical Mastectomy ◽

Distant Metastases ◽

Left Breast ◽

Secretory Breast Carcinoma

Abstract Background Secretory breast carcinoma is an uncommon subset of breast cancer that usually has a favorable outcome. Although initially described in children, it also occurs in adults where it may metastasize, possibly resulting in death. To date, only 20 cases of secretory breast carcinoma with distant metastases have been described. Case presentation A 42-year-old female presented with liver metastasis after modified radical mastectomy of the left breast in 2008 at 34 years of age. The liver metastasis was morphologically similar to the primary tumor. Pan-TRK and Fluorescence in situ hybridization showed a rearrangement in the ETV6 gene. She subsequently underwent adjuvant chemotherapy with a fatal outcome. Conclusions Although secretory breast carcinoma is usually associated with favorable outcomes, our study and reviews provide a novel insight into the genetic spectrum and treatment of secretory breast carcinoma showing reduced expression of hormone receptors, abnormal genomic profiles, and possible poor prognosis. Targeted therapy may curb clinically aggressive cases. Additional molecular investigations are needed to determine the links between specific mutations and poor prognosis.

Download Full-text

Uterine Carcinosarcoma after Prolonged Antiestrogenic Therapy-Pathohistological Characteristics, Immunohistichemical Analysis, Prognosis and Complex Treatment: A case report with literature review

Clinical Oncology Research and Reports ◽

10.31579/2693-4787/027 ◽

2021 ◽

Vol 2 (2) ◽

pp. 01-11

Author(s):

Lena Marinova ◽

Bistra Yordanova ◽

Nikolay Evgeniev

Keyword(s):

Breast Carcinoma ◽

Lymph Nodes ◽

Histological Study ◽

Immunohistochemical Analysis ◽

Distant Metastases ◽

Total Abdominal Hysterectomy ◽

Tamoxifen Treatment ◽

Peritoneal Cytology ◽

Uterine Carcinosarcoma ◽

Invasive Ductal Breast Carcinoma

Uterine carcinosarcoma (UCS) is a rare aggressive neoplasm.We present a clinical case with UCS, developed during along-term five years adjuvant tamoxifen treatment and ovarian suppression with LHRH agonist on the occasion of invasive ductal breast carcinoma. Crucial for obtaining diagnosis of this rare aggressive neoplasm is the strict pathohistological and immunohistochemical analysis, carried out by an experienced pathologist. Every patient with a history of breast carcinoma is a subject for periodic monitoring. Genital bleeding is required to perform a separated endometrial abrasion with a precise histological study. For UCS / III C2 FIGO stage without distant metastases is necessary to conduct a maximal surgical tumor reduction, involving ever total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, peritoneal cytology, and omentectomy, followed by a combined simultaneous chemo-radiotherapy of tumor bed and pelvic lymph nodes, definitive radiotherapy of para-aortical lymph nodes, as well as adjuvant chemotherapy.

Download Full-text

Alpha Radiation Emitters Device for the Treatment of Newly Diagnosed Breast Carcinoma Patients With Distant Metastases

Case Medical Research ◽

10.31525/ct1-nct03970967 ◽

2019 ◽

Author(s):

Keyword(s):

Breast Carcinoma ◽

Distant Metastases ◽

Newly Diagnosed ◽

Alpha Radiation

Download Full-text

Concordance of histology type between synchronous and metachronous contralateral breast carcinoma: Is there susceptibility for breast cancer of particular histology?

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e21030 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e21030-e21030

Author(s):

Zorica Tomasevic ◽

Dusica Gavrilovic ◽

Zoran Tomasevic ◽

Daniela Kolarevic

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Statistical Difference ◽

Lobular Carcinoma ◽

Progesterone Receptors ◽

Distant Metastases ◽

Tumor Grade ◽

Contralateral Breast ◽

Molecular Characteristics ◽

Significant Difference

e21030 Background: Contra-lateral breast cancer (CBC) is considered to be the most frequent new malignancy after primary breast cancer (PBC) However, there are few reports whether the histology and other major molecular characteristics differs between PBC and CBC. The aim of this paper is toevaluate and compare PBC/CBC histology according to the time to CBC development. Also, age at CBC and major molecular characteristics (tumor grade, estrogen/progesterone receptors, HER2) have been analyzed. Methods: A cohort of 113 patients with CBC, without distant metastases, has been prospectively registered during 28 months. Patients are divided in 2 groups according to the time of CBC diagnose: 1. Synchronous, if the CBC (S-CBC) was diagnosed either simultaneously or within 6 months after PBC; 2. Metachronous (M-CBC) if CBC was diagnosed > 6 months after PBC. Results: Results are presented in Table 1. Median age was calculated at the time of CBC diagnose. Patient with S-CBC are median 7 years older than patients with M- CBC that is statistically significant difference (p-0.007) S-CBC is more likely to be of the same histological type (76%) than M-CBC (56%) (p 0.006) In the whole analyzed group, and each subgroup separately, lobular carcinoma is registered in higher percentage (41%) than expected (~20%) For all other analyzed BC characteristics, statistical difference was not confirmed, however ~ 25% of specimens were not available for testing. Conclusions: Although it is still unclear what could be the clinical significance of these findings, genetic susceptibility to particular histology type of BC might be reasonably speculated. [Table: see text]

Download Full-text

Thyroid metastases from breast carcinoma: case report and review of literature

10.21203/rs.3.rs-45880/v1 ◽

2020 ◽

Author(s):

Yichao Wang ◽

Shengliang Zhou ◽

Boyang Yu ◽

Ping Zhou ◽

Zhihui Li ◽

...

Keyword(s):

Breast Carcinoma ◽

Lymph Nodes ◽

Distant Metastases ◽

Needle Aspiration ◽

Thyroid Lesion ◽

Cervical Lymph Nodes ◽

Left Chest ◽

History Of ◽

Thyroid Metastases ◽

The Right

Abstract Rationale: The thyroid is a rare site for distant metastases from breast carcinoma. The incidence of thyroid metastases in fine needle aspiration biopsy (FNAB) was less than 0.2%.Patient concerns: We report a case of 54-year-old woman with a history of breast carcinoma presented with diffuse scattered microcalcifications in thyroid and enlarged bilateral cervical lymph nodes detected on ultrasound (US). Physical examination of the patient revealed stiff and enlarged thyroid lobes.Diagnoses: FNAB and immunohistochemistry （IHC）of the thyroid lesion confirmed the thyroid metastases from breast cancer.Interventions and outcomes: Due to the comorbidities of breast carcinoma metastases to the right axillary, cervical lymph nodes and left chest wall, the patient received chemotherapy. After a follow-up of 10 months, the patient was alive without any new distant metastases.Lessons: Our case highlights that thyroid metastases should be considered in a patient combined with thyroid lesions and a history of breast carcinoma. IHC played an important role in differentiating thyroid metastases from primary thyroid cancer.

Download Full-text