scholarly journals Histologic response of dose-intense chemotherapy with preoperative hypofractionated radiotherapy for patients with high-risk soft tissue sarcomas

Cancer ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 2432-2439 ◽  
Author(s):  
Christopher W. Ryan ◽  
Anthony G. Montag ◽  
Janet R. Hosenpud ◽  
Brian Samuels ◽  
James B. Hayden ◽  
...  
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Hypofractionated Radiotherapy ◽  
Histologic Response

scholarly journals Hypofractionated preoperative radiotherapy for high risk soft tissue sarcomas in a geriatric patient population

2021 ◽  
Vol 55 (4) ◽  
pp. 459-466
Author(s):  
Vlatko Potkrajcic ◽  
Frank Traub ◽  
Barbara Hermes ◽  
Marcus Scharpf ◽  
Jonas Kolbenschlag ◽  
...  
Keyword(s):  
Wound Healing ◽  
High Risk ◽  
Soft Tissue ◽  
Geriatric Patient ◽  
Patient Population ◽  
Soft Tissue Sarcomas ◽  
Thoracic Wall ◽  
Hypofractionated Radiotherapy ◽  
Published Data ◽  
Specific Patient

Abstract Background Standard therapy for localised, resectable high risk soft tissue sarcomas consists of wide excision and radiotherapy over several weeks. This treatment schedule is hardly feasible in geriatric and frail patients. In order not to withhold radiotherapy from these patients, hypofractionated radiotherapy with 25 Gy in 5 fractions was evaluated in a geriatric patient population. Patients and methods A retrospective analysis was performed of 18 geriatric patients with resectable high risk soft tissue sarcomas of extremities and thoracic wall. Wound healing and short term oncologic outcome were analysed. In addition, dose constraints for radiotherapy of the extremities were transferred from normofractionated to hypofractionated radiotherapy regimens. Results Feasibility was good with 17/18 patients completing treatment as planned. Wound healing complication rate was in the range of published data. Two patients developed local and distant recurrence, two patients isolated distant recurrences. No isolated local recurrences were observed. Keeping the constraints was possible in all cases without compromising the coverage of the target volume. Conclusions Hypofractionated radiotherapy and surgery was well tolerated even in this specific patient population. With feasibility concerning early wound healing problems and adapted constraints, which allow for the treatment of most resectable extremity tumours, the concept warrants further evaluation in patients unfit for standard radiotherapy.

Predictive value of MRP-1 in localized high-risk soft tissue sarcomas: a translational research associated to ISG-STS 1001 randomized phase III trial.

2021 ◽  
pp. molcanther.0315.2021
Author(s):  
Javier Martín-Broto ◽  
Maria Lopez-Alvarez ◽  
David S Moura ◽  
Rafael Ramos ◽  
Paola Collini ◽  
...  
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Translational Research ◽  
Predictive Value ◽  
Soft Tissue Sarcomas ◽  
Phase Iii ◽  
Phase Iii Trial

scholarly journals The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas

2001 ◽  
Vol 84 (2) ◽  
pp. 244-252 ◽  
Author(s):  
S Maula ◽  
R L Huuhtanen ◽  
C P Blomqvist ◽  
T A Wiklund ◽  
P Laurila ◽  
...  
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Adhesion Molecule ◽  
Soft Tissue Sarcomas

Correlation of FDG PET-CT with histologic response after neoadjuvant chemotherapy for soft tissue sarcomas

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 10583-10583
Author(s):  
E. Y. Cheng ◽  
J. W. Froelich ◽  
J. C. Manivel ◽  
B. J. Weigel ◽  
K. M. Skubitz
Keyword(s):  
Soft Tissue ◽  
Fdg Pet ◽  
Soft Tissue Sarcomas ◽  
Response To Treatment ◽  
Additional Patient ◽  
High Grade ◽  
Continuous Variables ◽  
Histologic Response ◽  
Pet Ct ◽  
Fdg Pet Ct

10583 Background: Surrogate endpoints for survival are needed to allow rapid assessment of new therapies without doing lengthy studies using a survival endpoint. Non-invasive assessment of treatment response is also needed to guide chemotherapy. FDG- PET-CT has potential for assessing response to treatment in sarcoma. This study's goal was to correlate FDG-PET-CT, along with standard CT, with histologic response after chemotherapy for high grade soft tissue sarcomas before resection. Methods: Patients with high grade soft tissue sarcomas > 5 cm were enrolled in a prospective clinical trial and given ifosfamide/doxorubicin before tumor excision. FDG-PET-CT was performed at baseline before treatment, after cycle 1, & just before surgery. Differences in both SUVmax (baseline to cycle 1 [B-1], baseline to surgery [B-3]) and CT criteria (RECIST 1 dimension [1D], RECIST 2D & Choi) were compared to histologic response (> or < 90%) upon excision. Results: 25 patients were enrolled and 4 had disease progression prior to completing all 3 PET-CT's yielding 21 evaluable cases. 5 patients had SUVmax change of <40%: 4/5 (80%) had histologic response < 90% & 1/5 (20%) had histologic response >90%. 16 patients had SUVmax change of >40%: 12/16 (75%) had histologic response >90% & 4/16 (25%) had histologic response <90%. A scatterplot of SUVmax change (baseline to surgery), & histologic response as continuous variables revealed a Spearman's correlation coefficient = 0.55 (p<0.01). Conclusions: A cutoff value of 40% reduction in SUVmax from baseline to surgery appeared to differentiate histologic responders. Using this to define PET response, a correlation between PET response, as well as RECIST 1D and 2D, and histologic response was observed. Additional patient follow-up & further study of FDG-PET-CT as a surrogate endpoint for histologic response and survival is warranted. [Table: see text] [Table: see text]

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