Neuropeptide Y Y1 receptor mRNA in rodent brain: Distribution and colocalization with melanocortin-4 receptor

2004 ◽  
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1998 ◽  
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Joji Kato ◽  
Leonor Cantera ◽  
Lars Edvinsson

Neuroreport ◽  
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Shi Hsiang Shen ◽  
Remi Quirion

1997 ◽  
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Eric L Gustafson ◽  
Kelli E Smith ◽  
Margaret M Durkin ◽  
Mary W Walker ◽  
Christophe Gerald ◽  
...  

2000 ◽  
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Pierre P. Peyon ◽  
Xinwei Lin ◽  
Richard E. Peter

In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain.


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