scholarly journals Effectiveness of Statins as Primary Prevention in People With Different Cardiovascular Risk: A Population-Based Cohort Study

2018 ◽  
Vol 104 (4) ◽  
pp. 719-732 ◽  
Author(s):  
Maria Garcia-Gil ◽  
Marc Comas-Cufí ◽  
Jordi Blanch ◽  
Ruth Martí ◽  
Anna Ponjoan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Risk ◽  
Primary Prevention ◽  
Population Based

scholarly journals Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population‐based cohort study

2021 ◽  
Author(s):  
Ruixue Song ◽  
Kuan‐Yu Pan ◽  
Hui Xu ◽  
Xiuying Qi ◽  
Aron S. Buchman ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Risk ◽  
Population Based

scholarly journals Gender Inequalities in Diagnostic Inertia around the Three Most Prevalent Cardiovascular Risk Studies: Protocol for a Population-Based Cohort Study

2021 ◽  
Vol 18 (8) ◽  
pp. 4054
Author(s):  
Concepción Carratala-Munuera ◽  
Adriana Lopez-Pineda ◽  
Domingo Orozco-Beltran ◽  
Jose A. Quesada ◽  
Jose L. Alfonso-Sanchez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Health Care ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Disease Incidence ◽  
Population Based ◽  
Gender Inequalities ◽  
Primary Health Care Centers

Evidence shows that objectives for detecting and controlling cardiovascular risk factors are not being effectively met, and moreover, outcomes differ between men and women. This study will assess the gender-related differences in diagnostic inertia around the three most prevalent cardiovascular risk factors: dyslipidemia, arterial hypertension, and diabetes mellitus, and to evaluate the consequences on cardiovascular disease incidence. This is an epidemiological and cohort study. Eligible patients will be adults who presented to public primary health care centers in a Spanish region from 2008 to 2011, with hypertension, dyslipidemia, or/and diabetes and without cardiovascular disease. Participants’ electronic health records will be used to collect the study variables in a window of six months from inclusion. Diagnostic inertia of hypertension, dyslipidemia, and/or diabetes is defined as the registry of abnormal diagnostic parameters—but no diagnosis—on the person’s health record. The cohort will be followed from the date of inclusion until the end of 2019. Outcomes will be cardiovascular events, defined as hospital admission due to ischemic cardiopathy, stroke, and death from any cause. The results of this study could inform actions to rectify the structure, organization and training of health care teams in order to correct the inequality.

scholarly journals Prepregnancy Cardiovascular Risk Factors as Predictors of Preeclampsia: Population-based Cohort Study

2008 ◽  
Vol 28 (2) ◽  
pp. 79 ◽  
Author(s):  
E.B. Magnussen ◽  
L.J. Vatten ◽  
T.I. Lund-Nilsen ◽  
K.A. Salvesen ◽  
G. Davey Smith ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Population Based

scholarly journals Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France

2019 ◽  
Vol 40 (43) ◽  
pp. 3516-3525 ◽  
Author(s):  
Philippe Giral ◽  
Anke Neumann ◽  
Alain Weill ◽  
Joël Coste
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Primary Prevention ◽  
Cardiovascular Event ◽  
Structural Model ◽  
Medication Possession Ratio ◽  
Population Based ◽  
Cerebrovascular Event ◽  
Increased Risk ◽  
Time Varying Covariates

Abstract Aims The role of statin therapy in primary prevention of cardiovascular disease in persons older than 75 years remains a subject of debate with little evidence to support or exclude the benefit of this treatment. We assessed the effect of statin discontinuation on cardiovascular outcomes in previously adherent 75-year-olds treated for primary prevention. Methods and results A population-based cohort study using French national healthcare databases was performed, studying all subjects who turned 75 in 2012–14, with no history of cardiovascular disease and with a statin medication possession ratio ≥80% in each of the previous 2 years. Statin discontinuation was defined as three consecutive months without exposure. The outcome was hospital admission for cardiovascular event. The hazard ratio comparing statin discontinuation with continuation was estimated using a marginal structural model adjusting for both baseline and time-varying covariates (cardiovascular drug use, comorbidities, and frailty indicators). A total of 120 173 subjects were followed for an average of 2.4 years, of whom 17 204 (14.3%) discontinued statins and 5396 (4.5%) were admitted for a cardiovascular event. The adjusted hazard ratios for statin discontinuation were 1.33 [95% confidence interval (CI) 1.18–1.50] (any cardiovascular event), 1.46 (95% CI 1.21–1.75) (coronary event), 1.26 (95% CI 1.05–1.51) (cerebrovascular event), and 1.02 (95% CI 0.74–1.40) (other vascular event). Conclusion Statin discontinuation was associated with a 33% increased risk of admission for cardiovascular event in 75-year-old primary prevention patients. Future studies, including randomized studies, are needed to confirm these findings and support updating and clarification of guidelines on the use of statins for primary prevention in the elderly.

Efficacy of different statins for primary prevention of atrial fibrillation in male and female patients: A nationwide population-based cohort study

2013 ◽  
Vol 168 (4) ◽  
pp. 4367-4369 ◽  
Author(s):  
Chen-Ying Hung ◽  
Yu-Cheng Hsieh ◽  
Kuo-Yang Wang ◽  
Jin-Long Huang ◽  
El-Wui Loh ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Primary Prevention ◽  
Population Based ◽  
Male And Female ◽  
Female Patients

scholarly journals Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study

BMJ ◽  
2015 ◽  
Vol 350 (may19 2) ◽  
pp. h2335-h2335 ◽  
Author(s):  
A. Alperovitch ◽  
T. Kurth ◽  
M. Bertrand ◽  
M.-L. Ancelin ◽  
C. Helmer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Primary Prevention ◽  
Older People ◽  
Population Based ◽  
Lipid Lowering ◽  
Vascular Events ◽  
Lipid Lowering Drugs

scholarly journals PCV20 PERSISTENCE WITH STATINS AND PRIMARY PREVENTION OF CARDIOVASCULAR EVENTS: A POPULATION-BASED COHORT STUDY

2011 ◽  
Vol 14 (3) ◽  
pp. A35-A36
Author(s):  
G. Chodick ◽  
V. Shalev ◽  
I. Goldstein ◽  
A. Porath ◽  
V. Simah
Keyword(s):  
Cohort Study ◽  
Primary Prevention ◽  
Cardiovascular Events ◽  
Population Based

scholarly journals Cerebral small vessel disease, cardiovascular risk factors, and future walking speed in old age: a population-based cohort study

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Emerald G. Heiland ◽  
Anna-Karin Welmer ◽  
Grégoria Kalpouzos ◽  
Anna Laveskog ◽  
Rui Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Walking Speed ◽  
Small Vessel Disease ◽  
Population Based ◽  
Cerebral Small Vessel Disease ◽  
Vessel Disease

Abstract Background The purpose of this study was to examine the associations between combined and individual cerebral small vessel disease (cSVD) markers on future walking speed over 9 years; and to explore whether these associations varied by the presence of cardiovascular risk factors (CRFs). Methods This population-based cohort study included 331 adults, aged ≥60 years, without limitation in walking speed (≥0.8 m/s). At baseline, cSVD markers, including white matter hyperintensities (WMH), lacunes, and perivascular spaces (PVS), were assessed on magnetic resonance imaging. The modifiable CRFs (physical inactivity, heavy alcohol consumption, smoking, hypertension, high total cholesterol, diabetes, and overweight/obese) were combined into a score. The association between baseline cSVD markers and the decline in walking speed was examined using linear mixed-effects models, whereas Cox proportional hazards models were used to estimate the association with walking speed limitation (defined as < 0.8 m/s) over the follow-up. Results Over the follow-up period, 76 (23.0%) persons developed walking speed limitation. Participants in the highest tertile of the combined cSVD marker score had a hazard ratio (HR) of 3.78 (95% confidence interval [CI] 1.70-8.45) for walking speed limitation compared with people in the lowest score tertile, even after adjusting for socio-demographics, CRFs, cognitive function, and chronic conditions. When investigating the cSVD markers individually, having the highest burden of WMH was associated with a significantly faster decline in walking speed (β coefficient − 0.020; 95% CI -0.035-0.004) and a greater HR of walking speed limitation (HR 2.78; 95% CI 1.31-5.89) compared with having the lowest WMH burden. Similar results were obtained for the highest tertile of PVS (HR 2.13; 95% CI 1.04-4.36). Lacunes were associated with walking speed limitation, but only in men. Having ≥4 CRFs and high WMH volume simultaneously, showed a greater risk of walking speed limitation compared with having ≥4 CRFs and low WMH burden. CRFs did not modify the associations between lacunes or PVS and walking speed. Conclusions Combined cSVD markers strongly predict walking speed limitation in healthy older adults, independent of cognitive function, with WMH and PVS being the strongest contributors. Improving cardiovascular health may help to mitigate the negative effects of WMH on future walking speed.

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