Efficacy of different statins for primary prevention of atrial fibrillation in male and female patients: A nationwide population-based cohort study

2013 ◽  
Vol 168 (4) ◽  
pp. 4367-4369 ◽  
Author(s):  
Chen-Ying Hung ◽  
Yu-Cheng Hsieh ◽  
Kuo-Yang Wang ◽  
Jin-Long Huang ◽  
El-Wui Loh ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Primary Prevention ◽  
Population Based ◽  
Male And Female ◽  
Female Patients

scholarly journals Long-Term Incidence of Atrial Fibrillation and Stroke Among Cross-Country Skiers: Cohort Study of Endurance-Trained Male and Female Athletes

Circulation ◽  
2019 ◽  
Author(s):  
Niclas Svedberg ◽  
Johan Sundström ◽  
Stefan James ◽  
Ulf Hållmarker ◽  
Kristina Hambraeus ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Female Athletes ◽  
Male And Female ◽  
Cross Country

scholarly journals Acute cardiovascular events and all-cause mortality in patients with hyperthyroidism: a population-based cohort study

2017 ◽  
Vol 176 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Olaf M Dekkers ◽  
Erzsébet Horváth-Puhó ◽  
Suzanne C Cannegieter ◽  
Jan P Vandenbroucke ◽  
Henrik Toft Sørensen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Cardiovascular Events ◽  
Population Based ◽  
Arterial Embolism ◽  
Registration System ◽  
Increased Risk ◽  
All Cause Mortality

Objective Several studies have shown an increased risk for cardiovascular disease (CVD) in hyperthyroidism, but most studies have been too small to address the effect of hyperthyroidism on individual cardiovascular endpoints. Our main aim was to assess the association among hyperthyroidism, acute cardiovascular events and mortality. Design It is a nationwide population-based cohort study. Data were obtained from the Danish Civil Registration System and the Danish National Patient Registry, which covers all Danish hospitals. We compared the rate of all-cause mortality as well as venous thromboembolism (VTE), acute myocardial infarction (AMI), ischemic and non-ischemic stroke, arterial embolism, atrial fibrillation (AF) and percutaneous coronary intervention (PCI) in the two cohorts. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated. Results The study included 85 856 hyperthyroid patients and 847 057 matched population-based controls. Mean follow-up time was 9.2 years. The HR for mortality was highest in the first 3 months after diagnosis of hyperthyroidism: 4.62, 95% CI: 4.40–4.85, and remained elevated during long-term follow-up (>3 years) (HR: 1.35, 95% CI: 1.33–1.37). The risk for all examined cardiovascular events was increased, with the highest risk in the first 3 months after hyperthyroidism diagnosis. The 3-month post-diagnosis risk was highest for atrial fibrillation (HR: 7.32, 95% CI: 6.58–8.14) and arterial embolism (HR: 6.08, 95% CI: 4.30–8.61), but the risks of VTE, AMI, ischemic and non-ischemic stroke and PCI were increased also 2- to 3-fold. Conclusions We found an increased risk for all-cause mortality and acute cardiovascular events in patients with hyperthyroidism.

scholarly journals Association between Anemia and Stroke in Females: A Nationwide, Population-Based Cohort Study in Taiwan

2020 ◽  
Vol 17 (20) ◽  
pp. 7440
Author(s):  
Yuan Sui ◽  
Chien-Tai Hong ◽  
Li-Nien Chien ◽  
Hung-Yi Liu ◽  
Hung-Yi Chiou ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Stroke Risk ◽  
Medical Condition ◽  
Positive Association ◽  
Population Based ◽  
Reproductive Age ◽  
Research Database ◽  
Female Patients

Optimal stroke prevention strategies for women should take into account specific sex-related stroke risk factors. Anemia is a common medical condition in females, particularly in women of reproductive age. This study investigated whether anemia is an independent risk factor for stroke in females in a population-based cohort study. We investigated newly diagnosed anemic female patients with no history of central nervous system disease, psychiatric disorders, traumatic brain injury, major operations or hemorrhagic diseases identified from the Taiwan National Health Insurance Research Database. Non-anemic matched controls (1:1) were selected based on a propensity score estimated using a logistic regression model that included demographic characteristics and comorbidities. A competing risk analysis was applied to estimate the stroke risk in anemic patients compared to that of their matched controls. In our study, the adjusted sub-distribution hazard ratios (aSHRs) of overall, hemorrhagic and ischemic stroke in anemic female patients aged <50 years were 1.35 (95% confidence interval (CI): 1.19–1.52, p < 0.001), 1.31 (95% CI, 1.09-1.56, p < 0.003), and 1.35 (95% CI, 1.15–1.58, p < 0.001), respectively, compared to non-anemic female controls. However, a positive association between anemia and stroke was not found for those aged ≥50 years. Similar results were observed when the follow-up age was limited to 50 years to reduce the potential effects of menopause on stroke. In conclusion, the present population-based cohort study found that anemia is a potential risk factor for overall, hemorrhagic and ischemic stroke in females of reproductive age.

scholarly journals Oral anticoagulant and reduced risk of dementia in patients with atrial fibrillation: A population-based cohort study

Heart Rhythm ◽  
2020 ◽  
Vol 17 (5) ◽  
pp. 706-713 ◽  
Author(s):  
Pajaree Mongkhon ◽  
Laura Fanning ◽  
Wallis C.Y. Lau ◽  
Gary Tse ◽  
Kui Kai Lau ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Oral Anticoagulant ◽  
Population Based ◽  
Reduced Risk

scholarly journals Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study

2019 ◽  
Vol 127 (8) ◽  
pp. 087009 ◽  
Author(s):  
Saeha Shin ◽  
Richard T. Burnett ◽  
Jeffrey C. Kwong ◽  
Perry Hystad ◽  
Aaron van Donkelaar ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Air Pollution ◽  
Cohort Study ◽  
Ambient Air ◽  
Population Based ◽  
Ambient Air Pollution

scholarly journals Incidence, type of atrial fibrillation and risk factors for stroke: a population-based cohort study

2017 ◽  
Vol Volume 9 ◽  
pp. 53-62 ◽  
Author(s):  
Cecilia Johansson ◽  
Erik Dahlqvist ◽  
Jonas Andersson ◽  
Jan-Håkan Jansson ◽  
Lars Johansson
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cohort Study ◽  
Population Based

scholarly journals Comparison of postoperative outcomes among patients treated by male and female surgeons: a population based matched cohort study

BMJ ◽  
2017 ◽  
pp. j4366 ◽  
Author(s):  
Christopher JD Wallis ◽  
Bheeshma Ravi ◽  
Natalie Coburn ◽  
Robert K Nam ◽  
Allan S Detsky ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Postoperative Outcomes ◽  
Matched Cohort ◽  
Male And Female ◽  
Matched Cohort Study ◽  
Female Surgeons

Impact of liver disease on oral anticoagulant prescription and major adverse events in patients with atrial fibrillation: analysis from a population-based cohort study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Proietti ◽  
I Marzona ◽  
T Vannini ◽  
P Colacioppo ◽  
M Tettamanti ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Liver Disease ◽  
Risk Ratio ◽  
Major Bleeding ◽  
Oral Anticoagulant ◽  
Population Based ◽  
Primary Study ◽  
Secondary Bleeding ◽  
The Impact

Abstract Aims Data on the impact of liver disease (LD) in patients with atrial fibrillation (AF) and the role of oral anticoagulant (OAC) drugs for stroke prevention, are limited. We analysed the impact of LD and OAC treatment in determining stroke, major bleeding, all-cause death and secondary bleeding outcomes. Methods A retrospective observational population-based cohort study. The study cohort is derived from the administrative health databases of Lombardy region (&gt;10 million inhabitants), Italy. All AF patients ≥40 years admitted to hospital from 2000 to 2018 were considered. AF and LD diagnosis were established using ICD9-CM codes. Use of OAC was determined with Anatomical Therapeutic Chemical (ATC) codes. Primary study outcomes were stroke, major bleeding and all-cause death. Results Among 393,507 AF patients, 16,168 (4.1%) had concomitant LD. LD AF patients were significantly less treated with OAC independent of associated clinical characteristics (OR: 0.96, 95% CI: 0.92–0.98). Concomitant LD was found associated with an increased risk in all the study outcomes (HR: 1.18, 95% CI: 1.11–1.25 for stroke; HR: 1.57, 95% CI: 1.47–1.66 for major bleeding; HR: 1.41, 95% CI: 1.39–1.44 for all-cause death. Use of OAC in patients with AF and LD resulted in a reduction in stroke (HR: 0.80, 95% CI: 0.70–0.92), major bleeding (HR: 0.86, 95% CI: 0.74–0.99) and all-cause death (HR: 0.85, 95% CI: 0.80–0.90), with similar results according to several clinically relevant subgroups. A net clinical benefit (NCB) analysis suggested a positive benefit/risk ratio in using OAC in AF patients with LD (NCB: 0.408, 95% CI: 0.375–0.472). Conclusions In AF patients, concomitant LD carries a significantly higher risk for all clinical outcomes. Use of OAC in AF patients with LD was associated with a significant benefit/risk ratio, even in high-risk patient subgroups. Funding Acknowledgement Type of funding source: None

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