PROSPECTIVE STUDY OF SUBSTANCE-INDUCED AND INDEPENDENT MAJOR DEPRESSIVE DISORDER AMONG INDIVIDUALS WITH SUBSTANCE USE DISORDERS IN A NATIONALLY REPRESENTATIVE SAMPLE

This chapter describes seventeen important mental disorders and reviews studies of the prevalence of the disorders from around the world, presenting median and interquartile ranges for more than four hundred research studies. The range of prevalences is below 0.5% for eating disorders and schizophrenia, and above 5% for attention deficit hyperactivity disorder, major depressive disorder, phobias, personality disorders, and dementia. The chapter discusses methods for judging the disability adjusted life years (DALYs) for the disorders and compares estimates to other diseases considered in the Global Burden of Disease study. Mental and substance use disorders account for more than 160 million of the total DALYs in the world, or about 7% of the total. Major depressive disorder is the leading causes of DALYs among the mental and substance use disorders.

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Drug Use and the Risk of Major Depressive Disorder, Alcohol Dependence, and Substance Use Disorders

Archives of General Psychiatry ◽

10.1001/archpsyc.59.11.1039 ◽

2002 ◽

Vol 59 (11) ◽

pp. 1039 ◽

Cited By ~ 311

Author(s):

David W. Brook ◽

Judith S. Brook ◽

Chenshu Zhang ◽

Patricia Cohen ◽

Martin Whiteman

Keyword(s):

Substance Use ◽

Major Depressive Disorder ◽

Drug Use ◽

Depressive Disorder ◽

Alcohol Dependence ◽

Substance Use Disorders ◽

Major Depressive

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Structure of major depressive disorder in adolescents and adults in the US general population

The British Journal of Psychiatry ◽

10.1192/bjp.bp.111.098079 ◽

2012 ◽

Vol 201 (2) ◽

pp. 143-150 ◽

Cited By ~ 49

Author(s):

Femke Lamers ◽

Marcy Burstein ◽

Jian-ping He ◽

Shelli Avenevoli ◽

Jules Angst ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Latent Class Analysis ◽

Representative Sample ◽

Latent Class ◽

Longitudinal Research ◽

Class Analysis ◽

Major Depressive ◽

National Comorbidity Survey ◽

Nationally Representative

BackgroundAlthough techniques such as latent class analysis have been used to derive empirically based subtypes of depression in adult samples, there is limited information on subtypes of depression in youth.AimsTo identify empirically based subtypes of depression in a nationally representative sample of US adolescents, and to test the comparability of subtypes of depression in adolescents with those derived from a nationally representative sample of adults.MethodRespondents included 912 adolescents and 805 adults with a 12-month major depressive disorder, selected from the National Comorbidity Survey Adolescent Supplement and the National Comorbidity Survey Replication samples respectively. Latent class analysis was used to identify subtypes of depression across samples. Sociodemographic and clinical correlates of derived subtypes were also examined to establish their validity.ResultsThree subtypes of depression were identified among adolescents, whereas four subtypes were identified among adults. Two of these subtypes displayed similar diagnostic profiles across adolescent and adult samples (P=0.43); these subtypes were labelled ‘severe typical’ (adults 45%, adolescents 35%) and ‘atypical’ (adults 16%, adolescents 26%). The latter subtype was characterised by increased appetite and weight gain.ConclusionsThe structure of depression observed in adolescents is highly similar to the structure observed in adults. Longitudinal research is necessary to evaluate the stability of these subtypes of depression across development.

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Symptom Profiles of Major Depressive Disorder and Their Correlates among a Nationally Representative Sample

Social Work Research ◽

10.1093/swr/svx013 ◽

2017 ◽

Vol 41 (3) ◽

pp. 145-153

Author(s):

Jay O'Shields ◽

Greg Purser ◽

Orion Mowbray ◽

Claudette L Grinnell-Davis

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Representative Sample ◽

Major Depressive ◽

Symptom Profiles ◽

Nationally Representative

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Treatment of Depression in Patients with Alcohol or Drug Dependence

10.1093/med/9780190625085.003.0022 ◽

2018 ◽

Author(s):

J. Corey Williams ◽

Gustavo A. Angarita Africano

Keyword(s):

Substance Use ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Substance Use Disorders ◽

Main Study ◽

Major Depressive ◽

Treatment Of Depression ◽

Study Intervention ◽

Landmark Study

This chapter provides a summary of a landmark study on the treatment of major depressive disorder and co-morbid substance use disorders. Are antidepressants efficacious in treatment of combined depression and substance use disorders? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The main study findings suggest that Major Depressive Disorder can be effectively treated with antidepressant medications in patients with co-morbid substance use disorders. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

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