Cytomorphologic patterns of Pap and PAS-stained oral exfoliative cytology smears in adult Saudi diabetic patients as compared to healthy controls

2018 ◽  
Vol 46 (6) ◽  
pp. 501-506 ◽  
Author(s):  
Magdi Mansour Salih ◽  
Basem Hassan El-Esawy ◽  
Amal Abd El hafez ◽  
Afaf Abd El-Hafez
Keyword(s):  
Diabetic Patients ◽  
Healthy Controls ◽  
Exfoliative Cytology ◽  
Oral Exfoliative Cytology

scholarly journals Rapid detection of Candida albicans in oral exfoliative cytology samples by loop-mediated isothermal amplification

2017 ◽  
Vol 59 (4) ◽  
pp. 541-547 ◽  
Author(s):  
Hiroyasu Noguchi ◽  
Takashi Iwase ◽  
Daisuke Omagari ◽  
Masatake Asano ◽  
Ryota Nakamura ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Rapid Detection ◽  
Isothermal Amplification ◽  
Exfoliative Cytology ◽  
Loop Mediated Isothermal Amplification ◽  
Oral Exfoliative Cytology

Optical Sectioning of Oral Exfoliated Cells

1972 ◽  
Vol 51 (2) ◽  
pp. 560-568 ◽  
Author(s):  
Robert Hoffman ◽  
Leo Gross
Keyword(s):  
Cell Membrane ◽  
Interference Microscopy ◽  
Exfoliative Cytology ◽  
Optical Sectioning ◽  
Exfoliated Cells ◽  
Oral Exfoliative Cytology

Differential interference microscopy is suggested as an additional technique for oral exfoliative cytology. Optical sectioning provides clear views of the nucleus and other organelles that are not obstructed by underlying or overlying layers. With this technique, interlocking folds in the cell membrane can be observed clearly.

High resolution ultrasonography of peripheral nerves in diabetic patients to evaluate nerve cross sectional area with clinical profile

2021 ◽  
Vol 94 (1121) ◽  
pp. 20200173
Author(s):  
Shamrendra Narayan ◽  
Amit Goel ◽  
Ajai Kumar Singh ◽  
Anup Kumar Thacker ◽  
Neha Singh ◽  
...  
Keyword(s):  
Peripheral Nerves ◽  
Cross Sectional Area ◽  
Diabetic Patients ◽  
Tarsal Tunnel ◽  
Healthy Controls ◽  
Sectional Area ◽  
Cross Sectional ◽  
Early Therapy ◽  
Ultrasound Evaluation ◽  
Compressive Neuropathy

Objectives: The aim of this observational study was ultrasound evaluation of peripheral nerves cross-sectional area (CSA) in subjects with probable diabetic peripheral sensorimotor neuropathy (DPN). CSA was analyzed with reference to clinical and nerve conduction study’s (NCS) parameters for early diagnosis and pattern of involvement. Methods: A total of 50 patients with probable DPN due to Type 2 diabetes and 50 age-matched healthy controls underwent sonographic examinations of ulnar nerve at the lower arm, median nerve proximal to carpal tunnel, the common peroneal nerve proximal to fibular head, tibial nerve proximal to the tarsal tunnel, and sural nerve at lower third leg. Results: CSA was increased in cases of DPN as compared to healthy controls. Area changes were more marked with demyelinating pattern. Probable DPN cases with normal NCS had significantly higher number of peripheral nerves showing increased CSA as compared to healthy control. A cut-off of >4 nerve thickening showed a sensitivity of 86 %, and specificity of 56%. The neuropathy pattern in the lower limb was axonal, whereas in the upper limb, it was demyelinating with the majority showing sonographic feature of associated compressive neuropathy. Conclusion: There is an increase in CSA of peripheral nerve in diabetic patients. It can be used as a morphological marker for classifying DPN with changes being picked up earlier to NCS abnormality. Clinical neurological presentation in probable DPN can also be due to compressive neuropathy in early phases, and ultrasound can be a useful tool. Advances in knowledge: Early pick up of DPN cases shall be useful for early therapy and motivating the patients to actively participate in the treatment. Morphological changes on ultrasonography precedes the electrodiagnostic change in DPN. Symptoms of DPN is not only due to metabolic changes but also compressive neuropathy.

scholarly journals Evaluation of dentists’ knowledge of the use of oral exfoliative cytology in clinical practice

2014 ◽  
Vol 28 (1) ◽  
pp. 1-7
Author(s):  
Weber Adorno Silva ◽  
Ana Paula de Lima ◽  
Luana Marotta Reis De Vasconcellos ◽  
Ana Lia Anbinder
Keyword(s):  
Clinical Practice ◽  
Exfoliative Cytology ◽  
Oral Exfoliative Cytology

scholarly journals Role of micronucleus in oral exfoliative cytology

2015 ◽  
Vol 7 (6) ◽  
pp. 409 ◽  
Author(s):  
BK Akshatha ◽  
R Shashikala ◽  
AP Indira ◽  
GS Manjunath ◽  
KArathi rao
Keyword(s):  
Exfoliative Cytology ◽  
Oral Exfoliative Cytology

scholarly journals Efficacy of Oral Exfoliative Cytology in Diabetes Mellitus Patients: A Light Microscopic and Confocal Microscopic Study

2015 ◽  
Vol 16 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Deepika Gopal ◽  
N Malathi ◽  
B Thirupathi Reddy
Keyword(s):  
Diabetes Mellitus ◽  
Epithelial Cells ◽  
Microscopic Study ◽  
Exfoliative Cytology ◽  
Type 2 Dm ◽  
Buccal Epithelial Cells ◽  
Oral Exfoliative Cytology ◽  
Confocal Microscopic Study ◽  
Qualitative Changes

ABSTRACT Aim Diabetes mellitus (DM) has become a global problem. By monitoring the health status of these individuals, diabetic complications can be prevented. We aimed to analyze alterations in the morphology and cytomorphometry of buccal epithelial cells of type 2 DM patients using oral exfoliative cytology technique and determine its importance in public health screening, diagnosis and monitoring of diabetes mellitus. Materials and methods The study was carried out in 100 type 2 DM patients and 30 healthy individuals. Smears were taken from the right buccal mucosa and stained by the Papanicolaou technique. Staining with Acridine orange was carried out to view qualitative changes with confocal laser scanning microscope (LSM-510 Meta). The cytomorphometry was evaluated using IMAGE PRO PLUS 5.5 software with Evolution LC camera. All findings were statistically analyzed. Results The results showed that with increase in fasting plasma glucose levels, there is significant increase in nuclear area, decrease in cytoplasmic area, and increase in nuclear cytoplasmic ratio (p < 0.05) when compared to the control group. Various qualitative changes were noted, such as cell degeneration, micronuclei, binucleation, intracytoplasmic inclusion, candida and keratinization. Conclusion In the present study, we found significant alterations in the cytomorphometry and cytomorphology of buccal epithelial cells of type 2 DM patients. This study supports and extends the view that these cellular changes can alert the clinician to the possibility of diabetes and aid in monitoring of diabetes throughout the lifetime of the patient. How to cite this article Gopal D, Malathi N, Reddy BT. Efficacy of Oral Exfoliative Cytology in Diabetes Mellitus Patients: A Light Microscopic and Confocal Microscopic Study. J Contemp Dent Pract 2015;16(3):215-221.

scholarly journals Can hematological parameters in type 2 diabetes predict microvascular complication development?

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Erhan Onalan ◽  
Nevzat Gozel ◽  
Emir Donder
Keyword(s):  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Hematological Parameters ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Mean ◽  
The Difference

Objective: To examine potential associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume (MPV), HbA1c and microvascular complications in diabetic patients from a cost-effectiveness perspective. Methods: One hundred patients with type 2 diabetes attending our outpatient unit between May 2018 and October 2018 were included, and 100 healthy individuals served as the control group. A retrospective file search was performed to collect information on hemoglobin, mean platelet volume (MPV), glycosylated haemoglobin (HbA1c), hematocrit (Hct), neutrophil and lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelets (Plt), platelet/lymphocyte ratio (PLR), and microvascular complications (neuropathy, retinopathy, nephropathy). Results: Demographic and laboratory data were retrospectively controlled between diabetes (n=100) and healthy control (n=100) groups. The mean age in diabetic patients and healthy controls was 56.34 and 36.68 years, respectively. The mean NLR in diabetics and healthy controls was 2.48 and 2.11, the difference in NLR being significant (p=0.002). MPV in diabetics and controls was 8.54 and 8.53, respectively, and the difference was not significant (p=0.93). PLR was also similar, i.e. 149.7 and 145.3 in diabetics and healthy controls (p=0.067). With respect to microvascular complications, retinopathy was found to be significantly associated with MPV and NLR (p=0.015, and p=0.051), and nephropathy showed a significant association with NLR (p=0.027) among diabetics. In contrast with the two other microvascular complications, no significant association between neuropathy and NLR could be detected, while PLR and neuropathy was significantly associated (p=0.003). Conclusion: Microvascular complications may be associated with certain hematologic parameters, as suggested by comparisons both between diabetics and healthy individuals and within the group of diabetic individuals. We believe that hematologic parameters such as hematocrit, MPV, NLR, and PLR, which can be obtained through a simple complete blood count, may be utilized as cost-effective predictors of diabetic microvascular complications. Further prospective studies with larger sample size are required to better delineate these associations. doi: https://doi.org/10.12669/pjms.35.6.1150 How to cite this:Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development? Pak J Med Sci. 2019;35(6):1511-1515. doi: https://doi.org/10.12669/pjms.35.6.1150 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Oral Exfoliative Cytology in Case of Leprosy

1960 ◽  
Vol 72 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Toyozo Hidaka
Keyword(s):  
Exfoliative Cytology ◽  
Oral Exfoliative Cytology

Oral exfoliative cytology for the non-invasive diagnosis in X-linked Emery–Dreifuss muscular dystrophy patients and carriers

1998 ◽  
Vol 8 (2) ◽  
pp. 67-71 ◽  
Author(s):  
P Sabatelli ◽  
S Squarzoni ◽  
S Petrini ◽  
C Capanni ◽  
A Ognibene ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Exfoliative Cytology ◽  
Non Invasive ◽  
Oral Exfoliative Cytology

Elevated Concentrations of Soluble Adhesion Molecules and Large Platelets in Diabetic Patients: Are They Markers of Vascular Disease and Diabetic Nephropathy?

2007 ◽  
Vol 13 (4) ◽  
pp. 391-397 ◽  
Author(s):  
N. Bavbek ◽  
A. Kargili ◽  
O. Kaftan ◽  
F. Karakurt ◽  
A. Kosar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Mean Platelet Volume ◽  
Plasma Levels ◽  
Platelet Reactivity ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Soluble Adhesion Molecules ◽  
Protein Excretion

P-selectin, E-selectin, and mean platelet volume are markers associated with platelet reactivity that have been demonstrated to be increased in diabetes. We were particularly interested to see if there was a difference in mean platelet volume and selectins between diabetics and nondiabetics, and in diabetics with and without nephropathy, and whether there was a correlation between mean platelet volume and selectins. One hundred and fourteen diabetic patients and 31 healthy controls were investigated. Plasma levels of P-selectin and E-selectin were higher in the diabetic group than in controls ( P = .001 and P = .007, respectively) and in diabetic patients with proteinuria than in patients without proteinuria ( P = .002 and P = .004, respectively). Protein excretion was lower in patients with low mean platelet volume values ( P = .004). In conclusion, elevated platelet volume and high selectin values may play a role in the development of vasculopathies and complications in diabetes mellitus. Further studies are needed to prove these results.

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