Accuracy of imprint cytology and frozen section histology for intraoperative diagnosis of ovarian epithelial tumors: A comparative study and proposed algorithm

2021 ◽  
Author(s):  
Nozomi Nomura ◽  
Tomoko Sugiyama ◽  
Takuma Tajiri ◽  
Hirotaka Fujita ◽  
Shinichiro Hiraiwa ◽  
...  
Keyword(s):  
Comparative Study ◽  
Frozen Section ◽  
Imprint Cytology ◽  
Intraoperative Diagnosis ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors

scholarly journals Comparative Study of Imprint Cytology and Frozen Section in the Intraoperative Diagnosis of Thyroid Lesions

1970 ◽  
Vol 24 (1) ◽  
pp. 12-15 ◽  
Author(s):  
Sukumar Shaha ◽  
AJE Nahar Rahman
Keyword(s):  
Positive Predictive Value ◽  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Frozen Section ◽  
Cost Effective ◽  
Imprint Cytology ◽  
Intraoperative Diagnosis ◽  
Fresh Specimen ◽  
Sensitivity Specificity ◽  
Thyroid Lesions

 Imprint cytology can provide a useful adjunct to the frozen section diagnosis and may be used safely in the intraoperative diagnosis of thyroid nodules, especially in the centres where frozen section facilities are not available. This study was conducted to compare imprint cytology and frozen section in terms of diagnostic accuracy, sensitivity, specificity, positive predictive value and to assess the value of imprint cytology in the intraoperative diagnosis of thyroid lesions. A total of 57 consecutive patients were enrolled in the study. All of the patients underwent frozen section in the department of pathology, BSMMU, Dhaka. Imprints were taken from the fresh specimen sent for frozen section from departments of otolaryngology and surgery of BSMMU. Imprint slides were stained with rapid H & E staining method. Then the tissues were submitted for frozen section by standard method. In this study, diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value of imprint cytology were 81.25%, 66.66%, 82.59%, 87.12% respectively. Frozen section revealed the diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive as 88.46%, 72.72%, 100%, 100%, 83.33% respectively. Imprint cytology was found to be comparable with frozen section in diagnostic accuracy and sensitivity. Since imprint cytology is a simple and cost-effective procedure it can be used as an alternative to frozen section in hospitals where frozen section facilities are not available. Key Words: Imprint cytology, frozen section, intraoperative diagnosis of thyroid lesions  doi: 10.3329/bjpath.v24i1.2876 Bangladesh J Pathol 24 (1) : 12-15   

Diagnostic accuracy of intraoperative imprint cytology in ovarian epithelial tumors

2001 ◽  
Vol 72 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Y. Nagai ◽  
N. Tanaka ◽  
F. Horiuchi ◽  
S. Ohki ◽  
K. Seki ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Imprint Cytology ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors

scholarly journals Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls

2019 ◽  
Vol 143 (1) ◽  
pp. 47-64 ◽  
Author(s):  
Natalia Buza
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Ovarian Carcinomas ◽  
Intraoperative Frozen Section ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors ◽  
Wide Range ◽  
Frozen Section Diagnosis ◽  
Section Evaluation

Context.— Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Therefore, intraoperative frozen section evaluation is crucial for determining the required extent of surgery, that is, cystectomy for benign tumors, oophorectomy or limited surgical staging for borderline tumors in younger patients to preserve fertility, or extensive staging procedure for ovarian carcinomas. Ovarian epithelial tumors may exhibit a wide range of morphologic patterns, which often overlap with each other and can mimic a variety of other ovarian nonepithelial neoplasms as well. A combination of careful gross examination, appropriate sampling and interpretation of morphologic findings, and familiarity with the clinical context is the key to the accurate frozen section diagnosis and successful intraoperative consultation. Objective.— To review the salient frozen section diagnostic features of ovarian epithelial tumors, with special emphasis on useful clinicopathologic and morphologic clues and potential diagnostic pitfalls. Data Sources.— Review of the literature and personal experience of the author. Conclusions.— Frozen section evaluation of ovarian tumors continues to pose a significant diagnostic challenge for practicing pathologists. This review article presents detailed discussions of the most common clinical scenarios and diagnostic problems encountered during intraoperative frozen section evaluation of mucinous, serous, endometrioid, and clear cell ovarian tumors.

Comparison of Imprint Cytology and Frozen Section Techniques at Intraoperative Diagnosis: 381 Cases

1995 ◽  
Vol 5 (2) ◽  
pp. 157-163
Author(s):  
Muhan Erkuş ◽  
Süheyla Cumurcu ◽  
Aydın Şahin ◽  
Murat Cirik ◽  
Ümit Bayol
Keyword(s):  
Frozen Section ◽  
Imprint Cytology ◽  
Intraoperative Diagnosis

scholarly journals Comparison between imprint cytology and frozen sections in intraoperative consultation of ovarian tumours

2020 ◽  
Vol 8 (9) ◽  
pp. 3315
Author(s):  
Reily Ann Ivan ◽  
Kuruvilla P. Chacko ◽  
Pramod Thomas
Keyword(s):  
Malignant Tumors ◽  
Frozen Section ◽  
Mucinous Carcinoma ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Imprint Cytology ◽  
Primary Tumors ◽  
Intraoperative Diagnosis ◽  
Borderline Tumors ◽  
Ovarian Tumours

Background: The ovaries frequently are the site for various primary tumors. Correct intraoperative diagnosis is crucial. The application of imprint cytology is very useful where frozen section facility is not available. The present study is a comparison of imprint cytology and frozen section during intraoperative consultation for various types of benign and malignant ovarian neoplasms in different age groups.Methods: Seventy-six cases of ovarian tumors were examined using both imprint cytology and frozen section and evaluated, taking histopathological report as gold standard. The histopathological diagnoses consisted of benign (54), borderline (9), and malignant (13). The malignant tumors consisted of various types including serous carcinoma, mucinous carcinoma, endometrioid carcinoma, clear cell carcinoma and carcinoid.Results: All 54 benign cases were accurately diagnosed as benign by imprint cytology. With frozen section 53 cases were correctly diagnosed as benign but one case was over diagnosed as borderline. Among 13 malignant cases 11 (84.6%) were correctly diagnosed with both techniques. Borderline tumors were not able to be diagnosed with imprint smear, 3 out of 9 cases were correctly diagnosed with frozen section.Conclusion: When compared with frozen section, imprint cytology is a simple, inexpensive and useful diagnostic tool in intraoperative diagnosis of benign and malignant ovarian tumors. Imprint smear is not useful in borderline tumors where only frozen section is useful. Imprint cytology can be used as an adjunct to frozen section for better diagnosis.

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