Psoriasis: Hyperproliferative/inflammatory skin disorder

1988 ◽  
Vol 13 (2-3) ◽  
pp. 137-146 ◽  
Author(s):  
Vincent A. Ziboh
Keyword(s):  
Skin Disorder ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin

scholarly journals Therapeutic Response to Secukinumab in a 36-Year-Old Woman with Hidradenitis Suppurativa

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Astrid-Helene Ravn Jørgensen ◽  
Yiqiu Yao ◽  
Simon Francis Thomsen
Keyword(s):  
Antibiotic Therapy ◽  
Skin Disorder ◽  
Hidradenitis Suppurativa ◽  
Therapeutic Response ◽  
The Body ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder involving primarily the intertriginous skin of the axillary, inguinal, genital, and perianal areas of the body. It is characterized by recurrent inflamed nodules and abscesses, resulting in fistulae, fibrosis, and scarring. We present a case of HS refractory to local and systemic antibiotic therapy as well as anti-TNF and anti-IL12/23 that was successfully treated with secukinumab (anti-IL17A).

Plantar Psoriasis Associated with Olmesartan

2019 ◽  
Vol 14 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Ons Charfi ◽  
Talel Badri ◽  
Ghozlane Lakhoua ◽  
Sarrah Kastalli ◽  
Sihem El Aidli ◽  
...  
Keyword(s):  
Skin Disorder ◽  
Beta Blockers ◽  
Exceptional Case ◽  
Gold Salts ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin

Background: Psoriasis is a chronic inflammatory skin disorder that may be initiated or exacerbated by some drug intakes. Some of the most common medications known to trigger or worsen existing psoriasis include lithium, gold salts, beta blockers and antimalarials. Conclusion: We report an exceptional case of plantar psoriasis in a woman who was treated by olmesartan for 3 years.

New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: Can IL-38 help?

2020 ◽  
Vol 139 ◽  
pp. 109687 ◽  
Author(s):  
Dorita Lauritano ◽  
Gianpaolo Ronconi ◽  
Alessandro Caraffa ◽  
Carla Enrica Gallenga ◽  
Spyros K. Kritas ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Mast Cells ◽  
Allergic Contact Dermatitis ◽  
Skin Disorder ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin ◽  
Allergic Contact

scholarly journals Granuloma faciale – A case report

2020 ◽  
Vol 0 ◽  
pp. 1-3
Author(s):  
Sumi Thomas
Keyword(s):  
Case Report ◽  
Skin Disorder ◽  
Middle Aged ◽  
Granuloma Faciale ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin ◽  
Middle Aged Adults

Granuloma faciale is a rare localized idiopathic inflammatory skin disorder that manifests as reddish-brown or violaceous papules, plaques, or nodules. It usually occurs in middle-aged adults and is rare in children. We are reporting a case of granuloma faciale in a 31-year-old male.

scholarly journals Dermoscopic patterns in active and regressive lichen planus and lichen planus variants: a morphological study

2015 ◽  
pp. 45-53
Author(s):  
Sule Güngör ◽  
Ilteriş O. Topal ◽  
Emek K. Göncü
Keyword(s):  
Lichen Planus ◽  
Skin Disorder ◽  
Morphological Study ◽  
Disease Duration ◽  
Histopathological Examination ◽  
Before And After ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin ◽  
Lesion Localization

Background: Lichen planus (LP) is an acute or chronic inflammatory skin disorder characterized by discrete, violaceous, polygonal papules. Objective: In this study, we aimed to categorize the dermoscopic images of LP and LP variants before and after treatment. Methods: We analyzed and categorized the dermoscopic images of 255 LP lesions from 60 patients who had been clinically diagnosed with LP or LP variants and confirmed by histopathological examination. We reanalyzed and categorized the dermoscopic images of 50 lesions from fifteen patients after treatment. Results: We observed different Wickham striae (WS), pigment, and vascular patterns according to the LP variant, lesion localization and disease duration. Reticular, circular, linear, globular, radial streaming, perpendicular, and veil-like (structureless) WS patterns were detected on dermoscopic examination. Peripheral/diffuse dot globules, peripheral/diffuse peppering, perifollicular/annular, linear, reticular, circular, cobblestone, and homogeneous cloud-like pigment patterns were especially prevalent in LP pigmentosus and regressive LP lesions. As for vascular patterns, there were red dots/globules, radial linear, and peripheral homogeneous patterns described upon dermoscopic evaluation. Conclusion: Dermoscopic evaluation can be useful both in the diagnosis and follow up of LP.

scholarly journals Efficacy of Adding Oral Simvastatin to Topical Therapy for Treatment of Psoriasis: The Vietnamese Experience

2019 ◽  
Vol 7 (2) ◽  
pp. 237-242
Author(s):  
Hao Nguyen Trong ◽  
Thang Nguyen Tat ◽  
Tu Tran Nguyen Anh ◽  
Nhi Pham Uyen ◽  
Thuong Nguyen Van ◽  
...  
Keyword(s):  
General Population ◽  
Skin Disorder ◽  
Systemic Disease ◽  
Topical Therapy ◽  
Skin Lesions ◽  
Healthy Controls ◽  
Healthy Group ◽  
Pasi Score ◽  
Inflammatory Skin Disorder ◽  
Age And Sex

BACKGROUND: Psoriasis, the prevalence of which ranges from 2% to 3% of the general population, has been recently recognised as not only a chronic inflammatory skin disorder but also an immunometabolic systemic disease. Dyslipidemia is one of the most important comorbidities of psoriasis. Statins, frequently used as anti-hyperlipidemic agents, may be beneficial in the treatment of several autoimmune diseases, including psoriasis, due to their anti-inflammatory and immunomodulatory characteristics. Hence, we hypothesised that using this medication was not only beneficial for reducing hyperlipidemia but also improving psoriatic conditions. AIM: We conducted a study to determine the prevalence of dyslipidemia in psoriatic patients as well as whether the addition of statins (simvastatin prescribed forms) to standard topical antipsoriatic treatment can improve skin lesions in psoriatic patients. METHODS: A group of 128 psoriatic patients and 128 healthy controls who were matched with the patients regarding ethnicity, age, and sex were enrolled, and their lipid concentrations were determined. Furthermore, sixty patients were randomly selected from the former group and divided into two treatment subgroups to evaluate the effect of statins on the severity of psoriasis using the PASI score. RESULTS: We found that the rate of dyslipidemia in the patient group was significantly higher than in the healthy group (53.9% versus 21.9%, p < 0.001), particularly the triglyceride concentration (1.86 ± 1.17 versus 1.43 ± 0.79 mg/dL, p < 0.001). Also, the PASI score reduction in the simvastatin-treated subgroup was significantly different from that in the placebo-treated one after eight weeks of therapy (8.63 ± 4.78 versus 5.34 ± 3.59, p < 0.01). CONCLUSION: This study showed that simvastatin might play a role in controlling hyperlipidemia and in turn decrease the PASI score in psoriatic patients.

scholarly journals DDIT4 is an Innate Protector in Psoriatic Keratinocytes and 1,25(OH)2D3 Exerts Anti-Psoriasis Through Promoting DDIT4 Inducing Macro-Autophagy and Proliferation Inhibition

2020 ◽  
Author(s):  
Xiaojiao Zhang ◽  
Fuling Luo ◽  
Yi Luo ◽  
Jing Li ◽  
Jingyuan Wan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skin Disorder ◽  
Psoriasis Vulgaris ◽  
Proliferation Inhibition ◽  
High Concentration ◽  
Potential Therapeutic Target ◽  
Dihydroxyvitamin D3 ◽  
Inflammatory Skin Disorder ◽  
Activate Cell ◽  
First Time

Abstract Psoriasis vulgaris is a chronic inflammatory skin disorder. Its pathogenesis is now still unelucidated and the treatment is far from satisfied. DNA Damage-Inducible Transcript 4 (DDIT4) is a widely expressed protein in different tissue, which can activate cell macro-autophagy through mTORC1 passway. Vitamin D3 and analogues is a classic topical reagent for psoriasis vulgaris for more than 30 years, but its exact mechanism is not fully clear. In this study, we intend to verify whether vitamin D3 also exerts anti-psoriasis through promoting DDIT4 inducing macro-autophagy and proliferation inhibition in psoriasis vulgaris. Results showed DDIT4 was over-expressed in psoriatic tissue, and probably acted as an innate protector during psoriasis pathogenesis. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) could promote DDIT4 expression in a rough linear correlation and subsequently activate macro-autophagy and inhabit cell proliferation, especially at the high concentration of 100nM. In terms of our understanding, this is the first time to reveal the interactions between 1,25(OH)2D3, DDIT4 and macro-autophagy in psoriasis vulgaris. DDIT4 is also probably a potential therapeutic target in future psoriatic treatments.

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