scholarly journals Examining maternal influence on OLETF rats' early overweight: Insights from a cross-fostering study

2009 ◽  
Vol 51 (4) ◽  
pp. 358-366 ◽  
Author(s):  
Mariana Schroeder ◽  
Michal Schechter ◽  
Ester Fride ◽  
Timothy H. Moran ◽  
Aron Weller
1993 ◽  
Vol 265 (4) ◽  
pp. R749-R755 ◽  
Author(s):  
T. M. Lee

The importance of maternal photoperiodic history during lactation on the postnatal development of meadow vole pups was tested by cross-fostering pups on the day of birth between photorefractory females (housed for 26 wk in a 10:14-h light-dark cycle before mating) and photosensitive females (housed for 2 wk in a 10:14-h light-dark cycle before mating). Control pups were cross-fostered to females with the same photoperiodic history as the gestational dam. Somatic growth and food intake of cross-fostered pups were influenced by the photoperiod of the postnatal lactating dam. Pre- and postnatal maternal photoperiodic history interacted with the sex of the offspring to influence reproductive development. Pelage development was determined exclusively by the prenatal maternal photoperiodic history. The impact of a postnatal maternal influence on pup development of photoperiod-sensitive traits is discussed.


Appetite ◽  
2008 ◽  
Vol 51 (2) ◽  
pp. 408
Author(s):  
A. Weller ◽  
M. Schroeder ◽  
L. Shbiro ◽  
T.H. Moran

2019 ◽  
Vol 2019/2 ◽  
pp. 41-64
Author(s):  
S. C. ROWELL

CONCUBINE AND ENCHANTRESS: KATARZYNA TELNICZANKA AND HER BLACK MYTH Summary S.C. R O W E L L Katarzyna Hochstadt of Telnicz (ca 1480–1528), mistress of Sigismund the Old, mother of John of the Lithuanian Dukes, bishop of Vilnius (1519–36) and Poznań (1536–38) has come down in history as an enchanting beauty or a witch, or both. Her image is defined by her relationship with powerful men – her lover, her son, her husband (Andrzej Kościelecki, castellan of Wojnicz and sub–treasurer of the Crown of Poland) and alleged victims (various royal secretaries and high–ranking clerics). This article assesses what little by way of solid evidence is known of her life and how this can be related with the image of man–chasing vamp, interference in the running of the diocese of Vilnius (thereby allegedly provoking the appointment of bishop protectors to the see) and scandal in village and town (according to one seventeenth–century historian). There is evidence that while John of the Lithuanian Dukes was still a minor and enjoyed the rank of provost of Płock and Poznań and canon of Kraków the property associated with his office was overseen by his step–father and perhaps by his mother. After John became bishop of Vilnius, Her Magnificence the Bishop‘s Mother, the Lady Dowager Castellan of Wojnicz and Sub–Treasurer of the Crown of Poland resided for some time at her son‘s court in Vilnius and on at least two occasions exercised her maternal influence to facilitate access to the bishop for canons (Stanislaw Dambrowka, Martin of Dusniki and Albert Wielezinski) involved in a dispute with their brother canon and scholast Jakub Staszkowski. The detailed discussion of internal cathedral disputes in the presence of a lay person, and even worse, a woman, scandalised members of the Cathedral Chapter but there is no evidence that Lady Katarzyna sought to determine the outcome of this case. We also know that she patronised at least one noblewoman (the widowed sister–in–law of Bishop Albert Tabor) who subsequently adopted Bishop John as her son and heir and made financial endowments on both the bishop and his mother. After Katarzyna died in Vilnius in the late summer of 1528 her corpse was transported to Kraków for burial by a Vilnius canon, Erasmus Eustachii, whose family had connections with Andrzej Kościelecki and Bishop John of Vilnius. The satirical verse penned by Andrzej Krzycki concerning a mother–stepmother and father–stepfather (Katarzyna and King Sigismund) and „an old hag who stinks like a goat“ represents neo–Latin literary exercises provoked by fear of the influence at the royal court of Katarzyna and her family rather than an accurate and literal description of Katarzyna and her activities.


2015 ◽  
Vol 37 (3) ◽  
pp. 203-214 ◽  
Author(s):  
Joshua L. Cohen ◽  
Matthew E. Glover ◽  
Phyllis C. Pugh ◽  
Andrew D. Fant ◽  
Rebecca K. Simmons ◽  
...  

The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. The bHR/bLR traits are heritable, but prior work revealed bHR/bLR maternal style differences, with bLR dams showing more maternal attention than bHRs. The present study implemented a cross-fostering paradigm to examine the contribution of maternal behavior to the brain development and emotional behavior of bLR offspring. bLR offspring were reared by biological bLR mothers or fostered to a bLR or bHR mother and then evaluated to determine the effects on the following: (1) developmental gene expression in the hippocampus and amygdala and (2) adult anxiety/depression-like behavior. Genome-wide expression profiling showed that cross-fostering bLR rats to bHR mothers shifted developmental gene expression in the amygdala (but not hippocampus), reduced adult anxiety and enhanced social interaction. Our findings illustrate how an early-life manipulation such as cross-fostering changes the brain's developmental trajectory and ultimately impacts adult behavior. Moreover, while earlier studies highlighted hippocampal differences contributing to the bHR/bLR phenotypes, our results point to a role of the amygdala as well. Future work will pursue genetic and cellular mechanisms within the amygdala that contribute to bHR/bLR behavior either at baseline or following environmental manipulations.


Author(s):  
Lumin Wei ◽  
Rongjing Zhang ◽  
Jinzhao Zhang ◽  
Juanjuan Li ◽  
Deping Kong ◽  
...  

AbstractProtein kinase A (PKA) plays an important role in regulating inflammation via its catalytic subunits. Recently, PKA regulatory subunits have been reported to directly modulate some signaling pathways and alleviate inflammation. However, the role of PKA regulatory subunits in colonic inflammation remains unclear. Therefore, we conducted this study to investigate the role of the PKA regulatory subunit PRKAR2A in colitis. We observed that PRKAR2A deficiency protected mice from dextran sulfate sodium (DSS)-induced experimental colitis. Our experiments revealed that the intestinal epithelial cell-specific deletion of Prkar2a contributed to this protection. Mechanistically, the loss of PRKAR2A in Prkar2a−/− mice resulted in an increased IFN-stimulated gene (ISG) expression and altered gut microbiota. Inhibition of ISGs partially reversed the protective effects against DSS-induced colitis in Prkar2a−/− mice. Antibiotic treatment and cross-fostering experiments demonstrated that the protection against DSS-induced colitis in Prkar2a−/− mice was largely dependent on the gut microflora. Altogether, our work demonstrates a previously unidentified function of PRKAR2A in promoting DSS-induced colitis.


PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146662 ◽  
Author(s):  
Ying-Juan Liu ◽  
Yao-Hua Zhang ◽  
Lai-Fu Li ◽  
Rui-Qing Du ◽  
Jin-Hua Zhang ◽  
...  

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