An Extra Virgin Olive Oil‐enriched Chocolate Spread Positively Modulates Insulin‐Resistance Markers compared With a Palm Oil‐enriched one in Healthy Young Adults: A Double‐Blind, Cross‐Over, Randomized Controlled Trial.

Abstract BackgroundThe aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. MethodsWas conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9kg/m²): control group (CG, n=23), non-periodized group (NG, n=23), and linear periodized group (PG, n=23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50%–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2×10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2×12–14 to 2×8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. ResultsAfter 16 weeks of training, per protocol analysis (n=39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p=0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p=0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p=0.002). ConclusionPeriodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019 - https://ensaiosclinicos.gov.br/trial/5970/1

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Using prophylactic antioxidants to prevent noise-induced hearing damage in young adults: a protocol for a double-blind, randomized controlled trial

Trials ◽

10.1186/1745-6215-15-110 ◽

2014 ◽

Vol 15 (1) ◽

Cited By ~ 13

Author(s):

Annick Gilles ◽

Berina Ihtijarevic ◽

Kristien Wouters ◽

Paul Van de Heyning

Keyword(s):

Randomized Controlled Trial ◽

Young Adults ◽

Controlled Trial ◽

Double Blind ◽

Randomized Controlled ◽

Hearing Damage

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Effect of Extra Virgin Olive Oil and Traditional Brazilian Diet on the Bone Health Parameters of Severely Obese Adults: A Randomized Controlled Trial

Nutrients ◽

10.3390/nu12020403 ◽

2020 ◽

Vol 12 (2) ◽

pp. 403 ◽

Cited By ~ 6

Author(s):

Camila Kellen de Souza Cardoso ◽

Annelisa Silva e Alves de Carvalho Santos ◽

Lorena Pereira de Souza Rosa ◽

Carolina Rodrigues Mendonça ◽

Priscila Valverde de Oliveira Vitorino ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Olive Oil ◽

Bone Health ◽

Controlled Trial ◽

Virgin Olive Oil ◽

Extra Virgin Olive Oil ◽

Obese Adults ◽

Obese People ◽

Randomized Controlled ◽

Severely Obese

Dietary interventions can stabilize and/or reverse bone mass loss. However, there are no reports on its effects on bone mineral density (BMD) in severely obese people, despite the vulnerability of this group to bone loss. We examine the effect of extra virgin olive oil supplementation and the traditional Brazilian diet (DieTBra) on BMD and levels of calcium, vitamin D, and parathyroid hormone (PTH) in severely obese adults. A randomized controlled trial followed-up with severely obese adults (n = 111, with mean body mass index 43.6 kg/m2 ± 4.5 kg/m2) for 12 weeks. Study participants received either olive oil (52 mL/day), DieTBra, or olive oil + DieTBra (52 mL/day + DieTBra). BMD was assessed by total spine and hip dual-energy X-ray absorptiometry. After interventions, BMD means for total spine (p = 0.016) and total hip (p = 0.029) were higher in the DieTBra group than in the olive oil + DieTBra group. Final mean calcium levels were higher in the olive oil group compared to the olive oil + DieTBra group (p = 0.026). Findings suggest that DieTBra and extra virgin olive oil have positive effects on bone health in severely obese adults. The major study was registered at ClinicalTrials.gov (NCT02463435).

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