Kinetic spectrophotometric methods for the determination of artificial sweetener (sucralose) in tablets

2010 ◽  
Vol 3 (4) ◽  
pp. 214-220 ◽  
Author(s):  
Rasha M. Youssef ◽  
Mohamed A. Korany ◽  
Essam F. Khamis ◽  
Hoda Mahgoub ◽  
Miranda F. Kamal
Keyword(s):  
Artificial Sweetener ◽  
Spectrophotometric Methods ◽  
Kinetic Spectrophotometric

scholarly journals New Sensitive Kinetic Spectrophotometric Methods for Determination of Omeprazole in Dosage Forms

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Ashraf M. Mahmoud
Keyword(s):  
Reference Method ◽  
Fixed Time ◽  
Dosage Forms ◽  
Charge Transfer Complexes ◽  
Specific Rate ◽  
Spectrophotometric Methods ◽  
H Nmr ◽  
Nmr Techniques ◽  
Kinetic Spectrophotometric

New rapid, sensitive, and accurate kinetic spectrophotometric methods were developed, for the first time, to determine omeprazole (OMZ) in its dosage forms. The methods were based on the formation of charge-transfer complexes with both iodine and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The variables that affected the reactions were carefully studied and optimized. The formed complexes and the site of interaction were examined by UV/VIS, IR, and1H-NMR techniques, and computational molecular modeling. Under optimum conditions, the stoichiometry of the reactions between OMZ and the acceptors was found to be 1 : 1. The order of the reactions and the specific rate constants were determined. The thermodynamics of the complexes were computed and the mechanism of the reactions was postulated. The initial rate and fixed time methods were utilized for the determination of OMZ concentrations. The linear ranges for the proposed methods were 0.10–3.00 and 0.50–25.00   with the lowest LOD of 0.03 and 0.14   for iodine and DDQ, respectively. Analytical performance of the methods was statistically validated; RSD was <1.25% for the precision and <1.95% for the accuracy. The proposed methods were successfully applied to the analysis of OMZ in its dosage forms; the recovery was 98.91–100.32%  0.94–1.84, and was found to be comparable with that of reference method.

scholarly journals Kinetic Spectrophotometric Methods for the Determination of Isatin

2013 ◽  
Vol 25 (8) ◽  
pp. 4563-4568 ◽  
Author(s):  
Zeid A. Alothman ◽  
Masoom Raza Siddiqui ◽  
Saikh Mohammad Wabaidur ◽  
Hamad A. Al-Lohedan ◽  
Mohd. Sajid Ali ◽  
...  
Keyword(s):  
Spectrophotometric Methods ◽  
Kinetic Spectrophotometric

scholarly journals Kinetic Spectrophotometric Determination of Gemifloxacin Mesylate and Moxifloxacin Hydrochloride in Pharmaceutical Preparations Using 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Mohammed G. Abdel Wahed ◽  
Ragaa El Sheikh ◽  
Ayman A. Gouda ◽  
Sayed Abou Taleb
Keyword(s):  
Limit Of Detection ◽  
Kinetic Method ◽  
Pharmaceutical Preparations ◽  
Fixed Time ◽  
Spectrophotometric Methods ◽  
Relative Standard ◽  
Significant Difference ◽  
Kinetic Spectrophotometric ◽  
Comparison Of The Results

Simple, sensitive, and accurate kinetic spectrophotometric method was proposed for the determination of gemifloxacin mesylate (GMF) and moxifloxacin hydrochloride (MOX) in pure forms and pharmaceutical preparations (tablets). The method is based on coupling the studied drugs with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) in the presence of alkaline borate buffer. Spectrophotometric measurement was achieved by recording the absorbance at 466 and 464 nm for GMF and MOX, respectively, after a fixed time of 20 and 15 min on a water bath adjusted at 70 ± 5°C for both drugs. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized. The absorbance-concentration plots were linear over the ranges 0.5–8.0 and 2.0–12 μg mL−1for GMF and MOX, respectively. The limit of detection of the kinetic method was about 0.12 (2.47 × 10−7 M) and 0.36 (8.22 × 10−7 M) μg mL−1for GMF and MOX, respectively. The proposed methods have been applied and validated successfully with percentage relative standard deviation (RSD% ≤ 0.52) as precision and percentage relative error (RE% ≤ 1.33) as accuracy. The robustness of the proposed method was examined with recovery values that were 97.5–100.5 ± 1.3–1.9%. Statistical comparison of the results with the reference spectrophotometric methods shows excellent agreement and indicates no significant difference in accuracy or precision.

scholarly journals Kinetic and Conventional Spectrophotometric Determination of Bumadizone in its Tablets via Oxidative Coupling with 3-Methyl-2-Benzothiazolinone Hydrazone

2009 ◽  
Vol 5 (3) ◽  
pp. 839-854
Author(s):  
Mohamed Walash ◽  
Fathalla Belal ◽  
Manar Tolba ◽  
Mohamed Halawa
Keyword(s):  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Comparison Method ◽  
Spectrophotometric Methods ◽  
Oxidative Coupling Reaction ◽  
Bulk Drug ◽  
Kinetic Spectrophotometric ◽  
Chloride Method ◽  
Good Agreement

Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of bumadizone in bulk drug and its tablets. Both methods based on the oxidative coupling reaction with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) and measuring the absorbance of the developed colors by direct or kinetic spectrophotometric method. Upon treatment of a mixture of the chromogenic reagent and drug with cerium (IV) ammonium sulfate (method I) or ferric chloride (method I), a red or violet color was developed immediately or after 30 minutes measurable at 557 nm for method I or II, respectively. The absorbance-concentration plots were rectilinear over the ranges of 1-10 μg/mL (r = 0.9999) for method I and 2-16 μg/mL (r = 0.9998) for method II. The detection limits were  0.15 and 0.27 μg/mL & the quantitation limits were 0.46 and 0.84 μg/mL for methods I and II, respectively. Different experimental parameters affecting the development and stability of the reactions products were studied and optimized. The proposed methods were applied successfully to the determination of bumadizone in its tablets, and the results obtained were in good agreement with those obtained using a comparison  method. 

Analytical Applications of Permanganate as an Oxidant in the Determination of Pharmaceuticals Using Chemiluminescence and Spectrophotometry: A Review

2020 ◽  
Vol 16 (6) ◽  
pp. 670-686
Author(s):  
Habibur Rahman
Keyword(s):  
Potassium Permanganate ◽  
Pharmaceutical Formulations ◽  
Sequential Injection ◽  
Pharmaceutically Active Compounds ◽  
Active Compounds ◽  
Spectrophotometric Methods ◽  
Analytical Applications ◽  
Injection Techniques ◽  
Kinetic Spectrophotometric

Background: Potassium permanganate is a green and versatile industrial oxidizing agent. Due to its high oxidizing ability, it has received considerable attention and has been extensively used for many years for the synthesis, identification, and determination of inorganic and organic compounds. Objective: Potassium permanganate is one of the most applicable oxidants, which has been applied in a number of processes in several industries. Furthermore, it has been widely used in analytical pharmacy to develop analytical methods for pharmaceutically active compounds using chemiluminescence and spectrophotometric techniques. Results: This review covers the importance of potassium permanganate over other common oxidants used in pharmaceuticals and reported its extensive use and analytical applications using direct, indirect and kinetic spectrophotometric methods in different pharmaceutical formulations and biological samples. Chemiluminescent applications of potassium permanganate in the analyses of pharmaceuticals using flow and sequential injection techniques are also discussed. Conclusion: This review summarizes the extensive use of potassium permanganate as a chromogenic and chemiluminescent reagent in the analyses of pharmaceutically active compounds to develop spectrophotometric and chemiluminescence methods since 2000.

Sign in / Sign up

Export Citation Format

Share Document